Protein Alignment cwo and HEYL

DIOPT Version :9

• Sequence 1: NP_524775.1
• Gene: cwo / 44669
• FlyBaseID: FBgn0259938
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_055386.2
• Gene: HEYL / 26508
• HGNCID: 4882
• Length: 328
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 88/323 - (27%)
• Similarity: 127/323 - (39%)
• Gaps: 90/323 - (27%)

  Fly    46 EDDAEYATGRRNKTSRQ-DPLS------------HR-IIEKRRRDRMNSCLADLSRLIPPQYQRK 96
            |.|.....|:..:.|:. .|||            || |||||||||:||.|::|.||:|..::::
Human    13 ESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQ 77

  Fly    97 GRGRIEKTEIIEMAIRHLKHLQS-------ECQQKESDYRS-GYMDCMKEAAKFL---------- 143
            |..::||.|:::|.:.|||.|.:       :.:....|:|| |:.:|:.|..::|
Human    78 GSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRA 142

  Fly   144 YDVHMQDFCHRLLGRLQEHIDEM-----------FKTDCYKSTRSC--------------HMPDN 183
            ..|.:     |||..|..:..||           |....:....||              .:|..
Human   143 DPVRI-----RLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSP 202

  Fly   184 VSASSGSPHQAYHPPLCHLRDMLATSASDVEHSQDHNDV--KDLSFRNHLNQLQRSQQAAAAAAV 246
            |.....||  ||  |:..||......|:.:......|.:  :..|.......|:|
Human   203 VLPGVSSP--AY--PIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLER---------- 253

  Fly   247 AAAAVAVANGSSPASNAGVDSKV-PL------TNGGGTGGAPPAADNVPSNSTGSGSAAACAG 302
            .|..|.||    |:|.|...|.: ||      |..|.||.|...|...| ||:..|.|...||
Human   254 PATPVPVA----PSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTP-NSSSPGPAGRPAG 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cwo	NP_524775.1	HLH	66..118	CDD:306515	27/64 (42%)
		ORANGE	126..168	CDD:128787	14/63 (22%)
HEYL	NP_055386.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		15/43 (35%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		27/68 (40%)
		HLH	42..100	CDD:238036	27/57 (47%)
		ORANGE	115..162	CDD:128787	14/51 (27%)
		Atrophin-1	<136..311	CDD:331285	45/198 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..308		24/83 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840