Protein Alignment cwo and HEY2

DIOPT Version :9

• Sequence 1: NP_524775.1
• Gene: cwo / 44669
• FlyBaseID: FBgn0259938
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_036391.1
• Gene: HEY2 / 23493
• HGNCID: 4881
• Length: 337
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 92/367 - (25%)
• Similarity: 144/367 - (39%)
• Gaps: 87/367 - (23%)

  Fly    30 CTESSLNFSTSATAYSEDDAEYATGRRNKTSRQDPLS-------------------HRIIEKRRR 75
            |.|:        |:.|:.|.....|..|..|.|...|                   ..|||||||
Human     5 CEET--------TSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRR 61

  Fly    76 DRMNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQS-------ECQQKESDYRS-GY 132
            ||:|:.|::|.||:|..::::|..::||.||::|.:.|||.||:       :......|:.| |:
Human    62 DRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGF 126

  Fly   133 MDCMKEAAKFLYDVHMQDFCHRLLGRLQEHIDEMFKTDCYKSTRSCHMPDNVSASSGSPHQAYHP 197
            .:|:.|.|::|..|...|....|..||..|:.            :|......:|.:.|....:||
Human   127 RECLTEVARYLSSVEGLDSSDPLRVRLVSHLS------------TCATQREAAAMTSSMAHHHHP 179

  Fly   198 PLCHLRDMLATSASDVEHSQDHNDVKDLSFRNHL-------NQLQRSQQAAAAAAVAAAAVAVAN 255
              .|.....|..                   :||       |.|..|:......: ..:.|..|:
Human   180 --LHPHHWAAAF-------------------HHLPAALLQPNGLHASESTPCRLS-TTSEVPPAH 222

  Fly   256 GSS--PASNAGVDSKVPLTNGGGTGG-APPAADNVPSNSTGSGSAAACAGGNSNSSGSNSSNAAS 317
            ||:  .|:.|..||.:.:.:.|.... .||.:.::.|.|....:|||.|...::|  ...|.|.:
Human   223 GSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHS--FPLSFAGA 285

  Fly   318 STICPPAGGSCPAKVT----PL--AAHQQPHQAPVITSTAPH 353
            ..:.||...:..|..|    ||  :|...|.|....|:..|:
Human   286 FPMLPPNAAAAVAAATAISPPLSVSATSSPQQTSSGTNNKPY 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cwo	NP_524775.1	HLH	66..118	CDD:306515	25/70 (36%)
		ORANGE	126..168	CDD:128787	13/42 (31%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		10/54 (19%)
		bHLH-O_HEY2	40..121	CDD:381490	26/80 (33%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		26/68 (38%)
		ORANGE	119..165	CDD:128787	14/57 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..337		6/21 (29%)
		YRPW motif	327..330		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840