DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cwo and hes5.3

DIOPT Version :9

Sequence 1:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	XP_002933894.1	Gene:	hes5.3 / 100101782	XenbaseID:	XB-GENE-480450	Length:	160	Species:	Xenopus tropicalis

Alignment Length:	142	Identity:	42/142 - (29%)
Similarity:	69/142 - (48%)	Gaps:	25/142 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQYQ-RKGRGRIEKTEIIEMAIRHLKHLQSECQ 122
            |.:::.:...::||.||||:||.:..|..|:..::| .:...:.||.:|:|:|::.||  |..|.
Frog    21 TKQKNKIRKPMVEKMRRDRINSSINQLQNLLEKEFQLLQPDSKPEKADILELAVKFLK--QQICS 83

  Fly   123 QKES------DYRSGYMDCMKEAAKFLYDVHMQDFCHRLLGRLQEHIDEMFKTDCYKSTRSCHMP 181
            |.::      |:..||.:|:.|...||      .| ||....:|..:...|:  |..|     .|
Frog    84 QSKNNRKDYQDFSQGYSNCLHETFAFL------SF-HRTEEEMQLKLMNHFQ--CLDS-----QP 134

  Fly   182 DNVSASSGSPHQ 193
            ..:|.||.  ||
Frog   135 RGISVSSS--HQ 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cwo	NP_524775.1	HLH	66..118	CDD:306515	18/52 (35%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	11/47 (23%)
hes5.3	XP_002933894.1	bHLH-O_HES5	26..84	CDD:381467	20/59 (34%)
hes5.3	XP_002933894.1	Hairy_orange	93..135	CDD:383064	14/55 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100