Protein Alignment wech and Trim3

DIOPT Version :10

• Sequence 1: NP_524772.2
• Gene: wech / 44653
• FlyBaseID: FBgn0259745
• Length: 832
• Species: Drosophila melanogaster
• Sequence 2: XP_038948510.1
• Gene: Trim3 / 83616
• RGDID: 70074
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 814
• Identity: 184/814 - (22%)
• Similarity: 298/814 - (36%)
• Gaps: 202/814 - (24%)

  Fly   109 PKMSPESSNNSSISCGWCEVSASIRC---LECNEFMCNDCLR----------------------E 148
            |::.|  .:...:.|..|  ....||   |.|....|..||:                      |
  Rat    10 PEVQP--MDKQFLVCSIC--LDRYRCPKVLPCLHTFCERCLQNYIPPQSLTLSCPVCRQTSILPE 70

  Fly   149 HRNSPLSSNHSIVSLPTPIGASPTGGSSVNAQTPPSG----NFICDIH-------NEMLRYVCDY 202
            ...|.|.:|..|.||...:..:|.|........|.|.    ...|..|       ::.:.:.|:.
  Rat    71 QGVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSAVAGRPLSCPNHEGKEPLYHQTMEFYCEA 135

  Fly   203 CRKLVCQCCTLHEHKEHSYASIQSFMVGSKEKLEGAIESSQVGTRCIKSSIDKALAFIRLIERNC 267
            |...:|..|...||:||....::..:...|..|:..:|:       ::..:.:..|.|.|:....
  Rat   136 CETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEA-------VRGRLPQLSAAIALVGGIS 193

  Fly   268 SELSDNIRKAFRQFIIAIEDRERFLLDFVEKLRQRRLAILHD--QMAGLKSALAGLSETSDMLSK 330
            .:|.:...:|..|...|.||.|       :.|:||:.|::.|  .:.|.|..:  |....|.|.:
  Rat   194 QQLQERKAEALAQISAAFEDLE-------QALQQRKQALVSDLESICGAKQKV--LQTQLDTLRQ 249

  Fly   331 VAD---NACNMDQIEIAMKLTNG-------QRQMEQFAGIYKDLQPKQEVFAFAPPDYSLLQ--- 382
            ..:   ::|:.  .|.|::|.:.       :...|:.|.:.....|::      |.:.:.|:
  Rat   250 GQEHIGSSCSF--AEQALRLGSAPEVLLVRKHMRERLAALAAQAFPER------PHENAQLELVL 306

  Fly   383 -------DIRNQGGVILVDDKNLPIVSSSNGIVPS-------------------VSSVNAVAAAS 421
                   .:.|.|.::.........|::..|:..:                   |.:.:|...|.
  Rat   307 EVDGLRRSVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELCAE 371

  Fly   422 VGVVGGVAGVVGGVGVSNGL-----------DLAFGMNMPNNPLSVASSSVRRPLLRDNSFRI-- 473
            :....||...|..|...||.           ||...:.:...|            :|.:.||:
  Rat   372 ITGPDGVRLAVPVVDHKNGTYELVYTARTEGDLLLSVLLYGQP------------VRGSPFRVRA 424

  Fly   474 -------PSP------IMQPRGGSACGMSSGMSSAALDWELNGLRSSPGLH-----FSAPRTTQA 520
                   |||      :..|.|                         ||.|     ...|.:..:
  Rat   425 LRPGDLPPSPDDVKRRVKSPGG-------------------------PGSHVRQKAVRRPSSMYS 464

  Fly   521 IPGCMDLVKVRNSNAL--SLSF--ATEGHEDGQVSRPWGLCVDKMGHVLVSDRRNNRVQVFNPDG 581
            ..|      .|..|.:  .|.|  .:.|.|.|:.:...|:.....|.::|:|..|..:|||:.:|
  Rat   465 TGG------KRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQCIQVFSNEG 523

  Fly   582 SLKFKFGRKGVGNGEFDLPAGICVDVDNRIIVVDKDNHRVQIFTASGVFLLKFGSYGKEYGQFQY 646
            ..||:||.:|...|:...|.|:.||.:..|||.|.||..|.||:..|.|..|.|:     |:...
  Rat   524 QFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGA-----GRLMG 583

  Fly   647 PWDVAVNSRRQIVVTDSRNHRIQQFDSEGRFIRQIVFDNHGQT-KGIASPRGVCYTPTGNIIVSD 710
            |..|||:....|:|.|:::..:..|...|:.:.:  |...|.| :..|.|..|.......|:|:|
  Rat   584 PKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGR--FGGRGATDRHFAGPHFVAVNNKNEIVVTD 646

  Fly   711 FDNHCLYLIDPDINDILSVKGHEGSGFHEFNRPSGLCCDDEGRIIVADSKNQRILVFNQNLDFMW 775
            |.||.:.:...| .:.|...|..|.|..:||.|:|:..|..|.|||||..|.||.||:.:..|:
  Rat   647 FHNHSVKVYSAD-GEFLFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFL- 709

  Fly   776 DIEVRPSINPLMPPTLDEKDRTCDVAIMPDGRIV 809
             ..:..|..||..|.        .:|:..||.:|
  Rat   710 -SYINTSAEPLYGPQ--------GLALTSDGHVV 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wech	NP_524772.2	Bbox1	123..163	CDD:380815	14/64 (22%)
		Bbox2_TRIM66-like	187..228	CDD:380852	10/47 (21%)
		CC_brat-like	232..343	CDD:475168	24/115 (21%)
		NHL_TRIM71_like	528..810	CDD:271324	91/287 (32%)
		NHL repeat	553..592	CDD:271324	13/38 (34%)
		NHL repeat	600..639	CDD:271324	17/38 (45%)
		WD40 repeat	603..640	CDD:293791	15/36 (42%)
		WD40 repeat	647..684	CDD:293791	9/36 (25%)
		NHL repeat	647..683	CDD:271324	9/35 (26%)
		WD40 repeat	692..736	CDD:293791	13/43 (30%)
		NHL repeat	692..733	CDD:271324	12/40 (30%)
		NHL repeat	742..772	CDD:271324	14/29 (48%)
		WD40 repeat	743..767	CDD:293791	12/23 (52%)
Trim3	XP_038948510.1	RING-HC_TRIM3	16..63	CDD:438424	9/48 (19%)
		Bbox_SF	107..159	CDD:469587	10/51 (20%)
		BBC	164..290	CDD:128778	29/143 (20%)
		IG_FLMN	328..425	CDD:214720	17/108 (16%)
		NHL_TRIM2_like	477..750	CDD:271330	89/276 (32%)
		NHL repeat	495..534	CDD:271330	13/38 (34%)
		NHL repeat	542..581	CDD:271330	18/43 (42%)
		NHL repeat	584..621	CDD:271330	10/38 (26%)
		NHL repeat	628..669	CDD:271330	12/41 (29%)
		NHL repeat	675..717	CDD:271330	18/43 (42%)
		NHL repeat	720..746	CDD:271330	5/23 (22%)