DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wech and nhl-2

DIOPT Version :10

Sequence 1:NP_524772.2 Gene:wech / 44653 FlyBaseID:FBgn0259745 Length:832 Species:Drosophila melanogaster
Sequence 2:NP_498026.1 Gene:nhl-2 / 175654 WormBaseID:WBGene00003598 Length:1032 Species:Caenorhabditis elegans


Alignment Length:925 Identity:192/925 - (20%)
Similarity:308/925 - (33%) Gaps:340/925 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 CGWC--EVSASIRCLECNEFMCNDCLREHRNSPLSSNHSIVS---LPTPIGASPTGGSSVNAQTP 182
            |..|  |..|...|.:|:..:|.:|...|....|...|::.:   |..| ||.           |
 Worm   178 CTACKSEQEAIAFCDQCSSDLCENCTTAHTVMNLFQGHTVTTFADLRQP-GAH-----------P 230

  Fly   183 PSGNFICDIHNEMLRYVCDYCRKLVCQCCTLHEHKEHSYASIQSFMVGS-KEKLEGAIE------ 240
            .....:|..||:.:||:|..|....|:.|...:|..|....|...::.: :|.:...::      
 Worm   231 ELRQVMCSTHNQHMRYLCAACETAACKQCLEVDHLNHKIIDINELVINAIREDVTSTVDRVEKKY 295

  Fly   241 SSQVGTRCIKSSIDKA--------LAFIRLIERNCSELSDNIRKAFRQFIIAIED---RERFLLD 294
            ::.|..  :.|..||:        :|..| ::::..||.::|.:|:::.:..:|:   |:...:|
 Worm   296 NNSVAD--MNSLPDKSQQLNEQYEIAKYR-VDKHYEELRNSIEEAYQKSVNDLEEARIRQESNID 357

  Fly   295 FVEKLRQRRLAILHDQMAGLKSALA---GLSETSDMLSKVADNACNMD--------QIEIAMKLT 348
            .:.:..|...|.:||.:...:..|.   || |......||.....|:.        |:|:.. .|
 Worm   358 EMYRKSQVNEARVHDAINFTRRLLTKGNGL-ELVVSRKKVIQQFGNLSHAIPSHGHQVELEF-YT 420

  Fly   349 NGQRQMEQFAG------IYKDLQPKQEVFAFAPPDYSLLQDIRNQ----------------GGVI 391
            ..::|::.|..      |.:.:||             .::|:.|.                ||  
 Worm   421 PSKKQIDHFVHQLTGTVIGRVIQP-------------TVKDVGNATAASTDRSERGGSQPGGG-- 470

  Fly   392 LVDDKNLPIVSSSNGIVPS--------VSSVNAVAAASVGVVGGVA------GVVGGVGVSNGLD 442
                      .||:...||        |.|.|    ..:|.:||..      |..|..|.||   
 Worm   471 ----------RSSSAANPSQQDEWGRPVYSQN----PQLGAIGGERKKNTQNGTNGTRGDSN--- 518

  Fly   443 LAFG-----------------------------------------MNMPNNPLSVASSSVRRPLL 466
             |||                                         .|:||.....|:::..||.|
 Worm   519 -AFGGWPPSSHPPESTTPPPVTGPQTMITGAPTQTAAPIVSQQQLSNLPNAAAMAAAAAGMRPDL 582

  Fly   467 ----------------RDNSFRIPSP------IMQPRGG-------SACGMSSGMSSAALDWEL- 501
                            ..|..:.|.|      :...|.|       :..|:|:..|:|.:..:| 
 Worm   583 VALAANHMDLAALTNGSTNGSQTPLPESIFPAMWNARQGLPAVATPTTTGLSTNASAAYMQQKLA 647

  Fly   502 -------------------NGLRSSPGL-HFSA----------PRTTQAIPGCMDLVKVRNS--- 533
                               |.||::..: .|.|          |:.|.|....:......||   
 Worm   648 AAQLQALASHRLNPQIMSMNNLRTNQTIQEFLAMNAMGNLSLNPQLTSAAAAALAATAAANSAVT 712

  Fly   534 -------------NALSLS-------FAT--EGHEDGQVSRPWGLCVDKMGHVLVSDRRNNRVQV 576
                         ||..:|       |.|  :|....::..|.|.|:.....:|::|..|:||.|
 Worm   713 TTASDVGQSQNSANAQRVSDLKVHSVFGTSQQGSTIRELHCPSGFCLSDTDDILIADTNNHRVVV 777

  Fly   577 FNPDGSLKFKFGRKGVGNGEFDLP------AGICVDVDNRIIVVDKDNH---RVQIFTASGVFLL 632
            ..|..  .:|.||.|..:|:...|      .|..|    |.:|:||...   |.|||.|.|.|:.
 Worm   778 CGPPH--PWKIGRPGTDDGQLCFPRKVIALRGEAV----RYVVLDKGGDGKTRAQIFEARGEFVK 836

  Fly   633 KFGSY------GKEY--------GQ--------FQYP----------W-----------DVAVNS 654
            :....      |.|.        ||        |.|.          |           |||:..
 Worm   837 RLNMMALVPRGGIEVSAAAATPNGQLLLVDTAGFVYSIDVDAPRVTFWFDASTQLGEASDVAMFD 901

  Fly   655 RRQIVVTDSRNHRIQQFDSEGRFIRQIVFDNHGQTKGIASPRGVCYTPTGNIIVSDFDNHCLYLI 719
             ..|.:||.::|.:|.:.|||:|||::     |:......|.|:..:..|.::|:|...:.|:::
 Worm   902 -NLIYITDFKHHCVQVYTSEGKFIRKM-----GEPSQTPYPIGIDVSKAGEVLVADTHGNHLHVV 960

  Fly   720 DPDINDILSVKGHEGSGFHEF-------NRPSGLCCDDEGRIIVADSKNQRILVFNQNLDFMWDI 777
                     |...||...|.|       :|..||.....|.|:.....|..:.||          
 Worm   961 ---------VFSPEGQHIHSFTHNEFRLSRCVGLRIAKSGHIVTLCKHNHTLFVF---------- 1006

  Fly   778 EVRPSI--NPLMPPT 790
              :|.|  |.|..||
 Worm  1007 --KPLILPNGLPVPT 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wechNP_524772.2 Bbox1 123..163 CDD:380815 11/44 (25%)
Bbox2_TRIM66-like 187..228 CDD:380852 12/40 (30%)
CC_brat-like 232..343 CDD:475168 26/138 (19%)
NHL_TRIM71_like 528..810 CDD:271324 84/349 (24%)
NHL repeat 553..592 CDD:271324 13/38 (34%)
NHL repeat 600..639 CDD:271324 14/53 (26%)
WD40 repeat 603..640 CDD:293791 13/45 (29%)
WD40 repeat 647..684 CDD:293791 15/57 (26%)
NHL repeat 647..683 CDD:271324 15/56 (27%)
WD40 repeat 692..736 CDD:293791 9/43 (21%)
NHL repeat 692..733 CDD:271324 7/40 (18%)
NHL repeat 742..772 CDD:271324 8/29 (28%)
WD40 repeat 743..767 CDD:293791 5/23 (22%)
nhl-2NP_498026.1 RING-HC_RNF222 60..144 CDD:438226
Bbox_SF 178..220 CDD:469587 11/41 (27%)
BBOX 233..272 CDD:197662 11/38 (29%)
BBC 280..406 CDD:128778 25/129 (19%)
NHL_brat_like 729..1009 CDD:271329 74/312 (24%)
NHL repeat 754..788 CDD:271329 11/35 (31%)
NHL repeat 799..843 CDD:271329 14/47 (30%)
NHL repeat 846..887 CDD:271329 7/40 (18%)
NHL repeat 891..930 CDD:271329 15/44 (34%)
NHL repeat 935..974 CDD:271329 11/47 (23%)
NHL repeat 980..1006 CDD:271329 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

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