DRSC/TRiP Functional Genomics Resources

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Protein Alignment wech and TRIM71

DIOPT Version :10

Sequence 1:NP_524772.2 Gene:wech / 44653 FlyBaseID:FBgn0259745 Length:832 Species:Drosophila melanogaster
Sequence 2:NP_001034200.1 Gene:TRIM71 / 131405 HGNCID:32669 Length:868 Species:Homo sapiens


Alignment Length:910 Identity:269/910 - (29%)
Similarity:400/910 - (43%) Gaps:195/910 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 SSNAPSANNVAHSSTANGSGGGSVSSNASN---------------SSERLLAG--------ILES 57
            |||:.::::.:.:||::|.|||...:.|..               .:.||.|.        :...
Human    26 SSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLR 90

  Fly    58 FPAWDLNVGLLPNVGQSSPPRADFFINNFLGGLDTHGD-------FSIGPIGSGARSN------- 108
            .|..|..|.|....|..:.|.:.|.::|.|..:....|       .:..|.|:|..||       
Human    91 CPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHH 155

  Fly   109 --PKMS----------------------PESSNNSSI-----SCGWCEV--SASIRCLECNEFMC 142
              |:.|                      |.:|.::.:     .|..|:.  :||.|||:|.|.:|
Human   156 AHPRASASAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLC 220

  Fly   143 NDCLREHRNSPLSSNHSIVSLPTPIGAS------------PTGGSSVNAQTPPSGNFICDIH-NE 194
            ::|:|.|:...|:.:|.|...|...||:            |....|:.:..|....| |..| :|
Human   221 DNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGF-CQHHDDE 284

  Fly   195 MLRYVCDYCRKLVCQCCTLHEHKEHSYASIQSFMVGSKEKLEGAIESSQVGTRCIKSSIDKALAF 259
            :|...||.|...:|:.||:..|..||:..:|..:..|:......:..:|.|.:.|:.||::|...
Human   285 VLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTV 349

  Fly   260 IRLIERNCSELSDNIRKAFRQFIIAIEDRERFLLDFVEKLRQRRLAILHDQMAGLKSALAGLSET 324
            ...:|.....:...::....:...|:|:||..||..|||:||.:...|:.|:..|:..|..|..|
Human   350 AEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLEST 414

  Fly   325 SDMLSKVADNACNMDQIEIAMKLTNGQRQMEQFAGIYKDLQPKQ-EVFAFAPPDYSLLQDIRNQG 388
            ...:.:|.:....:|   |.:.......|:::...:...|||:: :...|.|||.:|...|::.|
Human   415 ISAVQQVLEEGRALD---ILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFG 476

  Fly   389 GVILVDDKNLPIVSSSNGIVPSVSSVN-------AVAAASVGVVG----GVAGVVGG-------V 435
            .|            ||....|...:..       ....||..|:|    |...:.||       :
Human   477 FV------------SSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVL 529

  Fly   436 GVSNGLDLAFGMNMPN--NPLSVASSSVRRPLLR--------------DNSFRIPSPIMQPRGGS 484
            |....|   ||..:.:  |...|.|   .||.|.              :||   |..::...|.|
Human   530 GPDGNL---FGAEVSDQQNGTYVVS---YRPQLEGEHLVSVTLCNQHIENS---PFKVVVKSGRS 585

  Fly   485 ACGMSSGMSSAALDWELNGLRSSPGLHFSAPRTTQAIPGCMDLVKVRNSNALSLSFATEGHEDGQ 549
            ..|:                               .:||              |||.:||..||:
Human   586 YVGI-------------------------------GLPG--------------LSFGSEGDSDGK 605

  Fly   550 VSRPWGLCVDKMGHVLVSDRRNNRVQVFNPDGSLKFKFGRKGVGNGEFDLPAGICVDVDNRIIVV 614
            :.||||:.|||.|:::|:||.|||:|||.|.|:...|||..|...|:||.|||:..|...||:|.
Human   606 LCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVA 670

  Fly   615 DKDNHRVQIFTASGVFLLKFGSYGKEYGQFQYPWDVAVNSRRQIVVTDSRNHRIQQFDSEGRFIR 679
            ||||||:||||..|.||||||..|.:.|||.|||||||||..:|:|:|:||||||.|..:|.|:.
Human   671 DKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLN 735

  Fly   680 QIVFDNHGQTKGIASPRGVCYTPTGNIIVSDFDNHCLYLIDPDINDILSVKGHEGSGFHEFNRPS 744
            :..|:. ...|...|||||.:...|:::|:||:||.|.:|.||......: |.||:|..:|.||.
Human   736 KYGFEG-ALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFL-GSEGTGNGQFLRPQ 798

  Fly   745 GLCCDDEGRIIVADSKNQRILVFNQNLDFMWDIEVRPSINPLMPPTLDEKDRTCDVAIMPDGRIV 809
            |:..|.|||||||||:|.|:.:|..|..|:.....:.|       ...:.||...:||.|||.||
Human   799 GVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGS-------GFGQMDRPSGIAITPDGMIV 856

  Fly   810  809
            Human   857  856

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wechNP_524772.2 Bbox1 123..163 CDD:380815 16/41 (39%)
Bbox2_TRIM66-like 187..228 CDD:380852 15/41 (37%)
CC_brat-like 232..343 CDD:475168 26/110 (24%)
NHL_TRIM71_like 528..810 CDD:271324 132/282 (47%)
NHL repeat 553..592 CDD:271324 21/38 (55%)
NHL repeat 600..639 CDD:271324 24/38 (63%)
WD40 repeat 603..640 CDD:293791 22/36 (61%)
WD40 repeat 647..684 CDD:293791 20/36 (56%)
NHL repeat 647..683 CDD:271324 20/35 (57%)
WD40 repeat 692..736 CDD:293791 18/43 (42%)
NHL repeat 692..733 CDD:271324 16/40 (40%)
NHL repeat 742..772 CDD:271324 17/29 (59%)
WD40 repeat 743..767 CDD:293791 14/23 (61%)
TRIM71NP_001034200.1 RING-HC_TRIM71_C-VII 1..102 CDD:438251 17/75 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..49 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 127..189 10/61 (16%)
Bbox1_TRIM71_C-VII 198..240 CDD:380870 16/41 (39%)
Bbox2_TRIM71_C-VII 277..322 CDD:380854 15/45 (33%)
CC_brat-like 314..444 CDD:475168 30/132 (23%)
Filamin 479..580 23/109 (21%)
Filamin 482..577 CDD:395505 21/103 (20%)
NHL_TRIM71_like 584..868 CDD:271324 136/327 (42%)
NHL 1 593..636 25/56 (45%)
NHL repeat 609..648 CDD:271324 21/38 (55%)
NHL 2 640..683 24/42 (57%)
NHL repeat 656..695 CDD:271324 24/38 (63%)
NHL 3 687..730 28/42 (67%)
NHL repeat 703..739 CDD:271324 20/35 (57%)
WD40 repeat 704..740 CDD:293791 19/35 (54%)
NHL 4 734..777 15/43 (35%)
NHL repeat 747..787 CDD:271324 16/40 (40%)
NHL 5 781..824 21/43 (49%)
NHL repeat 796..826 CDD:271324 17/29 (59%)
NHL 6 828..868 10/36 (28%)
NHL repeat 842..868 CDD:271324 9/15 (60%)

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