Protein Alignment Cnx99A and CNE1

DIOPT Version :9

• Sequence 1: NP_001036767.1
• Gene: Cnx99A / 44643
• FlyBaseID: FBgn0015622
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_009343.1
• Gene: CNE1 / 851241
• SGDID: S000000054
• Length: 502
• Species: Saccharomyces cerevisiae
• Alignment Length: 502
• Identity: 151/502 - (30%)
• Similarity: 226/502 - (45%)
• Gaps: 64/502 - (12%)

  Fly    52 AVIGGDEKLAYESPVIDAKKFHFADHFD---DVEESRKRWVLSQAKKDDIAEEISK-YDGIWNWE 112
            |::.|...|:..:...|:    |.:||.   :.:...:.|:.|:|    :..|.|| |...|...
Yeast    15 ALVKGTSLLSNVTLAEDS----FWEHFQAYTNTKHLNQEWITSEA----VNNEGSKIYGAQWRLS 71

  Fly   113 SP--QRIVWANDLGLVLKSKAKHAAIAAPLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLS 175
            ..  |...|  |.|:.:::....|.|...|..|........||||||:.|.....|||:::||:|
Yeast    72 QGRLQGSAW--DKGIAVRTGNAAAMIGHLLETPINVSETDTLVVQYEIKLDNSLTCGGAFIKLMS 134

  Fly   176 AGKDTEQLKAF-NDKTPYTIMFGPDKCGNDVK-MHFIFRHVNPINGTITEKHCNKPKNRLEEPFK 238
            ...:.|.||.: .|.....::||||.|..::. :.|....|:.|.      |.:|.:...|.|.
Yeast   135 GFMNVEALKHYAPDTEGVELVFGPDYCAPEINGVQFAINKVDKIT------HESKLRYLQEMPL- 192

  Fly   239 DKL-----PHLYQLVV-RPDNSFEIRVDHKIIN-----EGSLLTDFKPPVNPPAEIDDPNDHKPE 292
            .||     .|||.|:: ....||:|.:|.|.:.     |.....:|:||:.||..|.|.:..||.
Yeast   193 SKLTDTSQSHLYTLIIDESAQSFQILIDGKTVMVREHIEDKKKVNFEPPITPPLMIPDVSVAKPH 257

  Fly   293 SWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDEPDMIFDPTATKPEDWDAEIDGEW 357
            .||:|.:||||.|.|..|.||..|..:|..|...|..|....|:.|.||.|.||..|.....|||
Yeast   258 DWDDRIRIPDPEAVKLSDRDERDPLMIPHPDGTEPPEWNSSIPEYILDPNAQKPSWWKELEHGEW 322

  Fly   358 EAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQ 422
            ..|::.||:|....|||:....||.|..|||......|.||||.|:|.|.:|.||.::|:..|.:
Yeast   323 IPPMIKNPLCTAERGCGQQIPGLINNAKYKGPGELNEIINPNYMGEWHPPEIENPLYYEEQHPLR 387

  Fly   423 M-TPISAVGLELWSMSSDILFDNLIITDDVEVA------------RDFAANSFDIKRRYI----- 469
            : ..||.|.||.||.|.::|..|:.:..:|..|            |.|..:....:|:::
Yeast   388 IENVISGVILEFWSGSPNMLISNIYVGKNVTEAQIIGNKTWLMRDRAFRGSDGPTERKFMNSRLG 452

  Fly   470 --------DRESDSFVNKVVELAKANPSIWGIGLVAIVALVALTIYC 508
                    :|||.:..:::::.....|  ....|.|.|.|:..::.|
Yeast   453 NLQTTFHNERESPNPFDRIIDRILEQP--LKFVLTAAVVLLTTSVLC 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	133/392 (34%)
CNE1	NP_009343.1	Calreticulin	33..413	CDD:395201	133/392 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343260
Domainoid	1	1.000	201	1.000	Domainoid score	I558
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I842
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		otm46798
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	LDO	PTHR11073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	1	1.000	-	-		X875
TreeFam	0	0.000	Not matched by this tool.
	11	10.920