DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cnx99A and CANX

DIOPT Version :9

Sequence 1:	NP_001036767.1	Gene:	Cnx99A / 44643	FlyBaseID:	FBgn0015622	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001350922.1	Gene:	CANX / 821	HGNCID:	1473	Length:	646	Species:	Homo sapiens

Alignment Length:	603	Identity:	298/603 - (49%)
Similarity:	382/603 - (63%)	Gaps:	27/603 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLFASSLLLLSAANAAD---LDTESDDFED--GYVEDVQEEPAVIGGDEKLAYESPVIDAKKF 72
            |.:|......::.|.:..|   :|.| ||.:|  ..|||.:.:........|:.|::|| ...:.
Human    61 LCMLLVLGTAIVEAHDGHDDDVIDIE-DDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPV-PTGEV 123

  Fly    73 HFADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIA 137
            :|||.||  ..:...|:||:|||||..:||:||||.|..|..:......|.||||.|:|||.||:
Human   124 YFADSFD--RGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAIS 186

  Fly   138 APLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTE-QLKAFNDKTPYTIMFGPDKC 201
            |.|.|||.|.: |||:|||||..|.|.||||:|:||||  |..| .|..|:||||||||||||||
Human   187 AKLNKPFLFDT-KPLIVQYEVNFQNGIECGGAYVKLLS--KTPELNLDQFHDKTPYTIMFGPDKC 248

  Fly   202 GNDVKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINE 266
            |.|.|:||||||.||..|...|||..:|...|:..|.||..|||.|::.|||||||.||..::|.
Human   249 GEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNS 313

  Fly   267 GSLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWL 331
            |:||.|..|||||..||:||.|.|||.||||.|||||.|.||:|||||||.::||.:|..|.|||
Human   314 GNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWL 378

  Fly   332 EDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIE 396
            :|||:.:.||.|.||||||.::|||||||.:.||.||.|||||.|:.|:|.||||||||:.|||:
Human   379 DDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMID 443

  Fly   397 NPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANS 461
            ||:|||.|.|||||||||||||:||:|||.||:|||||||:|||.|||.||..|..:..|:|.:.
Human   444 NPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDG 508

  Fly   462 FDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAIVALVALTI-YCRFGTAKSQDSAAKKAAA 525
            :.:|:..........|.:::|.|:..|.:|.:.::.:...|.|.| :|..|  |.|.|     ..
Human   509 WGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSG--KKQTS-----GM 566

  Fly   526 EAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSDL-DDNEEESKAAESREPAQ 589
            |.||:|.||||.:.|.||:.:|:..||..:|.   ....::.||||. :|....|:..|.|:|..
Human   567 EYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEG---EEKLEEKQKSDAEEDGGTVSQEEEDRKPKA 628

  Fly   590 TEES--NTKTRKRQARKE 605
            .|:.  |...|.|:.|:|
Human   629 EEDEILNRSPRNRKPRRE 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	233/373 (62%)
CANX	NP_001350922.1	Calreticulin	125..494	CDD:306718	233/373 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145635
Domainoid	1	1.000	501	1.000	Domainoid score	I346
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1324
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1071
Isobase	1	0.950	-	0	Normalized mean entropy	S1544
OMA	1	1.010	-	-		QHG48587
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm8615
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.890