Protein Alignment Cnx99A and CALR

DIOPT Version :9

• Sequence 1: NP_001036767.1
• Gene: Cnx99A / 44643
• FlyBaseID: FBgn0015622
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_004334.1
• Gene: CALR / 811
• HGNCID: 1455
• Length: 417
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 158/543 - (29%)
• Similarity: 233/543 - (42%)
• Gaps: 151/543 - (27%)

  Fly    60 LAYESPVIDAKKFHFADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLG 124
            ||...|.:     :|.:.|.|.:....||:.|: .|.|..:.:......:..|.       .|.|
Human    14 LAVAEPAV-----YFKEQFLDGDGWTSRWIESK-HKSDFGKFVLSSGKFYGDEE-------KDKG 65

  Fly   125 LVLKSKAKHAAIAAPLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDK 189
            |.....|:..|::|.. :||..|. :.||||:.|..::..:|||.|:||.....|...:   :..
Human    66 LQTSQDARFYALSASF-EPFSNKG-QTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDM---HGD 125

  Fly   190 TPYTIMFGPDKCG-NDVKMHFIFRHVNPINGTITEKHCNKPKN-------RLEEPFKDKLPHLYQ 246
            :.|.||||||.|| ...|:|.||.:              |.||       |.::   |:..|||.
Human   126 SEYNIMFGPDICGPGTKKVHVIFNY--------------KGKNVLINKDIRCKD---DEFTHLYT 173

  Fly   247 LVVRPDNSFEIRVDHKIINEGSLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDW 311
            |:|||||::|:::|:..:..|||..|:  ...||.:|.||:..|||.||||.||.|||..|||||
Human   174 LIVRPDNTYEVKIDNSQVESGSLEDDW--DFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDW 236

  Fly   312 DEDAPPQLPDTDAVMPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKW 376
                                 |:|:.|.||.|.||||||.|:|||||
Human   237 ---------------------DKPEHIPDPDAKKPEDWDEEMDGEWE------------------ 262

  Fly   377 KAPLIPNPNYKGKWRAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDIL 441
             .|:|.||.|||:|:...|:||:|:|.|...:|.||::..|...:.......:||:||.:.|..:
Human   263 -PPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTI 326

  Fly   442 FDNLIITDDVEVARDFAANSFDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAIVALVALTI 506
            |||.:||:|...|.:|...:                             ||:
Human   327 FDNFLITNDEAYAEEFGNET-----------------------------WGV------------- 349

  Fly   507 YCRFGTAKSQDSAAKKAAAEAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSD 571
                          .|||  .|:..|.|.:::...|||.|::...:...|      ..:.::..|
Human   350 --------------TKAA--EKQMKDKQDEEQRLKEEEEDKKRKEEEEAE------DKEDDEDKD 392

  Fly   572 LDDNEEESKAAESRE--PAQTEE 592
            .|:.:||.|..:..|  |.|.::
Human   393 EDEEDEEDKEEDEEEDVPGQAKD 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	129/380 (34%)
CALR	NP_004334.1	N-domain	18..197		62/213 (29%)
		Calreticulin	23..332	CDD:395201	129/380 (34%)
		4 X approximate repeats	191..255		37/86 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..278		52/126 (41%)
		P-domain	198..308		59/151 (39%)
		Interaction with PPIB. /evidence=ECO:0000250	237..270		21/51 (41%)
		3 X approximate repeats	259..297		19/56 (34%)
		C-domain	309..417		34/171 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..417		19/74 (26%)
		Prevents secretion from ER	414..417		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940