DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cnx99A and CALR

DIOPT Version :10

Sequence 1:NP_477157.1 Gene:Cnx99A / 44643 FlyBaseID:FBgn0015622 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_004334.1 Gene:CALR / 811 HGNCID:1455 Length:417 Species:Homo sapiens


Alignment Length:543 Identity:158/543 - (29%)
Similarity:233/543 - (42%) Gaps:151/543 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 LAYESPVIDAKKFHFADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLG 124
            ||...|.:     :|.:.|.|.:....||:.|: .|.|..:.:......:..|.       .|.|
Human    14 LAVAEPAV-----YFKEQFLDGDGWTSRWIESK-HKSDFGKFVLSSGKFYGDEE-------KDKG 65

  Fly   125 LVLKSKAKHAAIAAPLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDK 189
            |.....|:..|::|.. :||..|. :.||||:.|..::..:|||.|:||.....|...:   :..
Human    66 LQTSQDARFYALSASF-EPFSNKG-QTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDM---HGD 125

  Fly   190 TPYTIMFGPDKCG-NDVKMHFIFRHVNPINGTITEKHCNKPKN-------RLEEPFKDKLPHLYQ 246
            :.|.||||||.|| ...|:|.||.:              |.||       |.::   |:..|||.
Human   126 SEYNIMFGPDICGPGTKKVHVIFNY--------------KGKNVLINKDIRCKD---DEFTHLYT 173

  Fly   247 LVVRPDNSFEIRVDHKIINEGSLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDW 311
            |:|||||::|:::|:..:..|||..|:  ...||.:|.||:..|||.||||.||.|||..|||||
Human   174 LIVRPDNTYEVKIDNSQVESGSLEDDW--DFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDW 236

  Fly   312 DEDAPPQLPDTDAVMPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKW 376
                                 |:|:.|.||.|.||||||.|:|||||                  
Human   237 ---------------------DKPEHIPDPDAKKPEDWDEEMDGEWE------------------ 262

  Fly   377 KAPLIPNPNYKGKWRAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDIL 441
             .|:|.||.|||:|:...|:||:|:|.|...:|.||::..|...:.......:||:||.:.|..:
Human   263 -PPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTI 326

  Fly   442 FDNLIITDDVEVARDFAANSFDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAIVALVALTI 506
            |||.:||:|...|.:|...:                             ||:             
Human   327 FDNFLITNDEAYAEEFGNET-----------------------------WGV------------- 349

  Fly   507 YCRFGTAKSQDSAAKKAAAEAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSD 571
                          .|||  .|:..|.|.:::...|||.|::...:...|      ..:.::..|
Human   350 --------------TKAA--EKQMKDKQDEEQRLKEEEEDKKRKEEEEAE------DKEDDEDKD 392

  Fly   572 LDDNEEESKAAESRE--PAQTEE 592
            .|:.:||.|..:..|  |.|.::
Human   393 EDEEDEEDKEEDEEEDVPGQAKD 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cnx99ANP_477157.1 Calreticulin 74..447 CDD:459737 129/380 (34%)
CALRNP_004334.1 N-domain 18..197 62/213 (29%)
Calreticulin 23..332 CDD:459737 129/380 (34%)
4 X approximate repeats 191..255 37/86 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..278 52/126 (41%)
P-domain 198..308 59/151 (39%)
Interaction with PPIB. /evidence=ECO:0000250 237..270 21/51 (41%)
3 X approximate repeats 259..297 19/56 (34%)
C-domain 309..417 34/171 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..417 19/74 (26%)
Prevents secretion from ER 414..417 0/2 (0%)

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