DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cnx99A and canx

DIOPT Version :9

Sequence 1:	NP_001036767.1	Gene:	Cnx99A / 44643	FlyBaseID:	FBgn0015622	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_998613.1	Gene:	canx / 406757	ZFINID:	ZDB-GENE-040426-2797	Length:	600	Species:	Danio rerio

Alignment Length:	621	Identity:	310/621 - (49%)
Similarity:	397/621 - (63%)	Gaps:	57/621 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLFASSLLLLSAANAADLDTESDDFE---DGYVEDVQEEPAVIGGDEKLA---YESPVIDAK- 70
            :|||..|..|||.....|. :.|:||.|   :..::|:|||.  |..:|:.|   ..:|.:..|
Zfish     9 VALLSLSLCLLLMGPVRAQ-EEEADDMEMDVEDAIDDMQEED--IEEEEQKAPAPPSAPTVTYKA 70

  Fly    71 -----KFHFADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSK 130
                 :.:||:.||  :.:.:.|||||||||.|.|:|:||||.|..|..|......|.|||||||
Zfish    71 PEPMGEHYFAEAFD--KGTLQGWVLSQAKKDGIDEDIAKYDGKWEVEEMQDSKLPGDKGLVLKSK 133

  Fly   131 AKHAAIAAPLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDKTPYTIM 195
            |||.||:|.|.:||.|.: |||:|||||..|.|.:|||:|:||||...|.: |:.|.||||||||
Zfish   134 AKHHAISALLLRPFTFDT-KPLIVQYEVNFQTGIDCGGAYVKLLSQTPDLD-LEEFVDKTPYTIM 196

  Fly   196 FGPDKCGNDVKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVD 260
            |||||||.|.|:||||||.||..|...|||..||.:.|...:.||..|||.||:.|||:|||.:|
Zfish   197 FGPDKCGEDYKLHFIFRHKNPKTGEFEEKHAKKPDSDLRSYYTDKKTHLYTLVLNPDNTFEILID 261

  Fly   261 HKIINEGSLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAV 325
            ..::|.||||.|..|||||||||:||:|||||.||||.||.||.|.||||||||||.::.|.|||
Zfish   262 QTVVNSGSLLNDVTPPVNPPAEIEDPDDHKPEDWDERPKIQDPDAVKPEDWDEDAPAKIADEDAV 326

  Fly   326 MPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKW 390
            .|:|||:|||:.|.||.|.||||||.::|||||||.:.|||||.|||||.|:.|:|.||||||||
Zfish   327 KPDGWLDDEPEYISDPDAVKPEDWDEDMDGEWEAPQIPNPVCETAPGCGAWERPMIDNPNYKGKW 391

  Fly   391 RAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVAR 455
            ::|||:||||||.|.|||||||||||||.||:|||.||||||||||||||.|||..||.|..||.
Zfish   392 KSPMIDNPNYQGVWKPRKIPNPDFFEDLHPFRMTPFSAVGLELWSMSSDIFFDNFFITSDRNVAE 456

  Fly   456 DFAANSFDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAI-VALVALTIYCRFGTAKSQDSA 519
            .:|.:.:.:|:..........||:::..|:..|.:|.:.::.: :.||.:.::|..|    :.|:
Zfish   457 RWANDGWGLKKAAEGAAEPGLVNQMITAAEERPWLWIVYVLTVALPLVLIIVFCCTG----KKSS 517

  Fly   520 AKKAAAEAKKSDDPQP------------DDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSDL 572
            |...||:.||:|:|||            |:||||::..:|.:.||...:.|.        :..|.
Zfish   518 ASTPAAKYKKTDEPQPDVKEEAEEEEAKDEEPEAKKSEEEDSTGDGDGDDTA--------ENGDK 574

  Fly   573 DDNEEESKAAES---REPAQTEESNTKTRKRQARKE 605
            |||....|:.:.   |.|          |.|::||:
Zfish   575 DDNTSNEKSEDDILRRSP----------RNRKSRKD 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	243/372 (65%)
canx	NP_998613.1	Calreticulin	79..448	CDD:278680	243/372 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579032
Domainoid	1	1.000	518	1.000	Domainoid score	I295
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1324
Inparanoid	1	1.050	586	1.000	Inparanoid score	I960
OMA	1	1.010	-	-		QHG48587
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm6387
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940