DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnx99A and calr

DIOPT Version :9

Sequence 1:	NP_001036767.1	Gene:	Cnx99A / 44643	FlyBaseID:	FBgn0015622	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_956007.2	Gene:	calr / 325317	ZFINID:	ZDB-GENE-030131-4042	Length:	417	Species:	Danio rerio

Alignment Length:	536	Identity:	160/536 - (29%)
Similarity:	236/536 - (44%)	Gaps:	154/536 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 HFADHFDDVEESRKRWVLSQAKKD--DIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAA 135
            :|.:.|:|.:..|.|||.|:.|.|  .......|:.|...          .|.||.....|...|
Zfish    23 YFREQFEDGDSWRSRWVESKHKTDYGKFVLSAGKFYGDAE----------KDKGLQTSQDAHFYA 77

  Fly   136 IAAPLRKPFEFKS-DKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDKTPYTIMFGPD 199
            ::|...   :|.: |:|||:|:.|..::..:|||.|:||..:  |..|.....|.| |.||||||
Zfish    78 MSARFG---DFNNKDQPLVIQFSVKHEQNIDCGGGYIKLFPS--DLNQEDMHGDST-YNIMFGPD 136

  Fly   200 KCG-NDVKMHFIFRHVNPINGTITEKHCNKPKNRL-EEPFK---DKLPHLYQLVVRPDNSFEIRV 259
            .|| ...|:|.||.:              |.||.| .:..:   |:..|||.|:|.|||::|:::
Zfish   137 ICGPGTKKVHVIFNY--------------KGKNHLINKDIRCKDDEYSHLYTLIVNPDNTYEVKI 187

  Fly   260 DHKIINEGSLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDA 324
            |:|.:..|||..|:  ...|..:|.||...|||.|||||||.||...|||:|
Zfish   188 DNKKVESGSLEEDW--DFLPSKKIKDPEAKKPEDWDEREKIDDPEDQKPEEW------------- 237

  Fly   325 VMPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGK 389
                    |:|:.|.||.|.||:|||.|:|||||.|:|                   .||:|||:
Zfish   238 --------DKPENIPDPDAKKPDDWDEEMDGEWEPPMV-------------------TNPDYKGE 275

  Fly   390 WRAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVA 454
            |:...|:||.|:|||...:|.||::..|.:.::...|..:||:||.:.|..:|||.:||:|.::|
Zfish   276 WKPRQIDNPAYKGKWVHPEIDNPEYTADSEIYKYDSIGVIGLDLWQVKSGTIFDNFLITNDPKLA 340

  Fly   455 RDFAANSFDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAIVALVALTIYCRFGTAKSQDSA 519
            .:....:                             |                   |..|..:..
Zfish   341 EEVGTET-----------------------------W-------------------GATKDAEKK 357

  Fly   520 AKKAAAE--AKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSDLDDNEEESKAA 582
            .|::..|  .||.|:.:...:.||:||.:|                    :|.:.|:.|||.:..
Zfish   358 MKESQEEEDRKKHDEEEKSRKEEAKEEEEE--------------------EKEEEDEEEEEEEEE 402

  Fly   583 ESREPAQTEESNTKTR 598
            |..|    ||:::|.:
Zfish   403 EDEE----EETDSKLK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	133/380 (35%)
calr	NP_956007.2	Calreticulin	24..333	CDD:278680	133/380 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940