Protein Alignment Cnx99A and cnx-1

DIOPT Version :9

• Sequence 1: NP_001036767.1
• Gene: Cnx99A / 44643
• FlyBaseID: FBgn0015622
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_499176.1
• Gene: cnx-1 / 176390
• WormBaseID: WBGene00000567
• Length: 619
• Species: Caenorhabditis elegans
• Alignment Length: 626
• Identity: 247/626 - (39%)
• Similarity: 357/626 - (57%)
• Gaps: 54/626 - (8%)

  Fly    16 LFASSLLLLSAANAADLDTESDDFEDGYVEDVQEEPAVIGGDEKLAYESPVIDAKKF------HF 74
            :|...||:.|      :.::.|.|||      .||....|.|:|..:...:..|.|.      :|
 Worm     9 IFIQFLLVSS------IRSDDDVFED------DEEEVTKGSDDKEEFVPSLFVAPKLSDKSTPNF 61

  Fly    75 ADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIAAP 139
            .|:|....:....|:.|.|||||:..:|:||:|.|:..:|.::....||||::|:||:|.||||.
 Worm    62 FDYFPVGSKIGLTWIKSLAKKDDVDSDIAKYNGEWSIGAPTKVSIEGDLGLIVKTKARHHAIAAK 126

  Fly   140 LRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDKTPYTIMFGPDKCGND 204
            |..||.|.:: ..||||::..:|||||||.||||||.|.: :.|..|.|||.|||||||||||..
 Worm   127 LNTPFAFDAN-TFVVQYDIKFEEGQECGGGYLKLLSEGAE-KDLANFQDKTAYTIMFGPDKCGAT 189

  Fly   205 VKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEGSL 269
            .|:|.|||:.|||||||:|.|.|:|.......:.|...||:.|||:|...:.:.||.|.:..|::
 Worm   190 GKVHLIFRYKNPINGTISEYHANQPTTIGSTYWDDHNTHLFTLVVKPTGEYSVSVDGKSLYYGNM 254

  Fly   270 LTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDE 334
            ::|..|.:.||.:|.|..|.||..|||||.|.|.:|.||:||||:.|..:.|..|..|..|.|:|
 Worm   255 MSDVTPALTPPKQIFDETDLKPVDWDERENIEDESAVKPDDWDENEPQSVVDEAATKPYDWNEEE 319

  Fly   335 PDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPN 399
            .::|.||.|.||:|||.::||.|||||:|||.|:...|||.||||.|.||.|||||..|.|.||.
 Worm   320 NELIADPEAKKPQDWDEDMDGSWEAPLIDNPACKGLSGCGTWKAPTIKNPKYKGKWIRPKISNPA 384

  Fly   400 YQGKWAPRKIPNPDFFEDLKPFQ-MTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFD 463
            ::|||..|.|.||::||. |||. :.||:|||:|:|:||.:|||||::||...|.:.|.|..:|.
 Worm   385 FKGKWTARLIDNPNYFEP-KPFAGLAPITAVGIEMWTMSENILFDNILITSSEEDSSDVAKQTFY 448

  Fly   464 IKRRYIDR------ESDSFVNKVVELAKANPSIWGIGLVAI-VALVALTIYCRFGTAKSQDSAAK 521
            :|::...|      ..:.|..::::.....|.:|.:.::.: :.|||:.::|....:|...:.||
 Worm   449 VKQKEEYRLAAATGNGNGFFQQIIDATNEKPWLWAVYILCVLLPLVAIGVFCFGKQSKPTPNFAK 513

  Fly   522 KAAAEAKKSDDPQ-----PDDEPE--AEEESDERAAGDTSKESTPLSASPKKN---------QKS 570
            |  ::|..:||.:     .|||.|  .:||.|....|.:..:|.|.....::|         |.|
 Worm   514 K--SDAYSADDDRVPNLVDDDEEEIIGDEEDDVNQPGPSGSQSNPEPQDEEENAEQQSANSSQSS 576

  Fly   571 DLDDNEEESKAAESREPAQTEESNTKT-------RKRQARK 604
            ..::.::|....|:.....|||...|:       ::|.||:
 Worm   577 AAEEEDDEHVVPENEPVKPTEEFAKKSPKNTGGAKRRTARR 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	188/373 (50%)
cnx-1	NP_499176.1	Calreticulin	61..432	CDD:278680	188/373 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158665
Domainoid	1	1.000	397	1.000	Domainoid score	I378
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1324
Inparanoid	1	1.050	447	1.000	Inparanoid score	I907
Isobase	1	0.950	-	0	Normalized mean entropy	S1544
OMA	1	1.010	-	-		QHG48587
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		otm14272
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	LDO	PTHR11073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890