DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cnx99A and Clgn

DIOPT Version :9

Sequence 1:	NP_001036767.1	Gene:	Cnx99A / 44643	FlyBaseID:	FBgn0015622	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_011246598.1	Gene:	Clgn / 12745	MGIID:	107472	Length:	615	Species:	Mus musculus

Alignment Length:	614	Identity:	279/614 - (45%)
Similarity:	371/614 - (60%)	Gaps:	44/614 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLLSAANAADLD--TESDDFEDGYVE-DVQEEPAVIGGDEKLAYESPVIDAKKFHFADHFDDVEE 83
            ||....||..:|  .|.:||.:...| ::::||:  .|..|.....|:   .:.:|.:.||  ..
Mouse    16 LLFITVNADFMDDGVEVEDFSENSDESNIKDEPS--SGTFKYKTPQPI---GEVYFTETFD--SG 73

  Fly    84 SRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIAAPLRKPFEFKS 148
            :...||||:|||||:..||:.|||.|..|..:......|.||||||||||.||||.|.|||.| :
Mouse    74 NLAGWVLSKAKKDDMDSEIAIYDGRWEIEELKENQVPGDRGLVLKSKAKHHAIAAVLEKPFIF-A 137

  Fly   149 DKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQ--LKAFNDKTPYTIMFGPDKCGNDVKMHFIF 211
            ||||:|||||..|:|.:|||:|:|||:   ||..  |:.|.|||.|||||||||||.|.|:|.||
Mouse   138 DKPLIVQYEVNFQDGIDCGGAYIKLLA---DTGDLILENFYDKTSYTIMFGPDKCGEDYKLHLIF 199

  Fly   212 RHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEGSLLTDFKPP 276
            ||.:|..|...|||...|...|:|.|.|:..|||.||:.||::||:.:|.|::|:|:||.|..||
Mouse   200 RHKHPKTGVFEEKHAKPPDVDLKEFFTDRKTHLYTLVMNPDDTFEVLIDQKVVNQGTLLDDVVPP 264

  Fly   277 VNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDEPDMIFDP 341
            :|||.|||||:|.|||.||:|.|||||||.:||||||:.|.|:.|:.||.|:|||:|||..|.:|
Mouse   265 INPPREIDDPSDKKPEEWDDRAKIPDPTAVRPEDWDENEPAQIEDSSAVKPDGWLDDEPKFIPNP 329

  Fly   342 TATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPNYQGKWAP 406
            .|.|||||..::|||||||.:.||.|:  .|||:||.|:|.||.|||.||.|||.||||||.|:|
Mouse   330 KAEKPEDWSDDMDGEWEAPHIPNPACQ--IGCGEWKPPMIDNPKYKGIWRPPMINNPNYQGLWSP 392

  Fly   407 RKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDIKRRYIDR 471
            :||||||:|||..||.:|..||:|||||||:.||.|||.||..:.|||..:|.:.:::|....:.
Mouse   393 QKIPNPDYFEDDHPFLLTSFSALGLELWSMTPDIYFDNFIICSEKEVADQWATDGWELKIMVANA 457

  Fly   472 ESDSFVNKVVELAKANPSIWGIGLVAI---VALVALTIYCRFGTAKSQDSAAK---------KAA 524
            .....:.::|..|:..|.:|.:.||..   |||||...:.|....|.:|:..|         |||
Mouse   458 NEPGVLRQLVIAAEERPWLWLMYLVMAGLPVALVASFCWPRKVKKKYEDTGPKKTELCKLQSKAA 522

  Fly   525 AEAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSD---LDDNEEESKAAES-- 584
            .|.:..::..|:...:.:||.....|...:.|...: ..|::..|.|   |:..||.||.::|
Mouse   523 LEQEAEEEKAPEKPEDVQEEKKPGEAEVVTVEKEVI-GEPEEKSKEDRETLEGQEEVSKLSKSGS 586

  Fly   585 --------REPAQTEESNTKTRKRQARKE 605
                    ..|...:......|||:.||:
Mouse   587 EDEMKDADESPGSGDAPLKSLRKRRVRKD 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	219/374 (59%)
Clgn	XP_011246598.1	Calreticulin	66..433	CDD:365986	219/374 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835701
Domainoid	1	1.000	502	1.000	Domainoid score	I343
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1087
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm8849
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	LDO	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900