DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cnx99A and Canx

DIOPT Version :9

Sequence 1:NP_001036767.1 Gene:Cnx99A / 44643 FlyBaseID:FBgn0015622 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_001103969.1 Gene:Canx / 12330 MGIID:88261 Length:591 Species:Mus musculus


Alignment Length:608 Identity:298/608 - (49%)
Similarity:380/608 - (62%) Gaps:49/608 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LLLLSAA----------NAADLDTESDDFEDGYVEDVQEEPAVIGGDEKLAYESPVIDAKKFHFA 75
            ||:|..|          :|.|::.:.||..:...:...:..|......|:.|::|| ...:.:||
Mouse    10 LLVLGTAAVEAHDGHDDDAIDIEDDLDDVIEEVEDSKSKSDASTPPSPKVTYKAPV-PTGEVYFA 73

  Fly    76 DHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIAAPL 140
            |.||  ..|...|:||:|||||..:||:||||.|..:..:......|.||||.|:|||.||:|.|
Mouse    74 DSFD--RGSLSGWILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPGDKGLVLMSRAKHHAISAKL 136

  Fly   141 RKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTE-QLKAFNDKTPYTIMFGPDKCGND 204
            .|||.|.: |||:|||||..|.|.||||:|:||||  |..| .|..|:|||||||||||||||.|
Mouse   137 NKPFLFDT-KPLIVQYEVNFQNGIECGGAYVKLLS--KTAELSLDQFHDKTPYTIMFGPDKCGED 198

  Fly   205 VKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEGSL 269
            .|:||||||.||..|...|||..:|...|:..|.||..|||.|::.|||||||.||..::|.|:|
Mouse   199 YKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNL 263

  Fly   270 LTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDE 334
            |.|..|||||..||:||.|.|||.||||.||.||.|.||:|||||||.::||.:|..|.|||:||
Mouse   264 LNDMTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPSKIPDEEATKPEGWLDDE 328

  Fly   335 PDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPN 399
            |:.|.||.|.||||||.::|||||||.:.||.||.|||||.|:.|:|.||||||||:.|||:|||
Mouse   329 PEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMIDNPNYKGKWKPPMIDNPN 393

  Fly   400 YQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDI 464
            |||.|.|||||||||||||:||:|||.||:|||||||:|||.|||.||:.|..|..|:|.:.:.:
Mouse   394 YQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDDWANDGWGL 458

  Fly   465 KRRYIDRESDSFVNKVVELAKANPSIWGIGLVAIVALVALTI-YCRFGTAKSQDSAAKKAAAEAK 528
            |:..........|.:::|.|:..|.:|.:.::.:...|.|.| :|..|..:|.       |.|.|
Mouse   459 KKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQSN-------AMEYK 516

  Fly   529 KSDDPQPD--DEPEAEEESDERAAGDTSKESTPLSASPKKNQKSDLDD-------NEEESKAAES 584
            |:|.||||  ||...|||.::|   |..:|...|    ::.||||.::       :||:||    
Mouse   517 KTDAPQPDVKDEEGKEEEKNKR---DEEEEEEKL----EEKQKSDAEEDGVTGSQDEEDSK---- 570

  Fly   585 REPAQTEES--NTKTRKRQARKE 605
              |...|:.  |...|.|:.|:|
Mouse   571 --PKAEEDEILNRSPRNRKPRRE 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cnx99ANP_001036767.1 Calreticulin 74..447 CDD:278680 234/373 (63%)
CanxNP_001103969.1 Calreticulin 72..441 CDD:278680 234/373 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..347 55/85 (65%)
P domain (Extended arm). /evidence=ECO:0000250 277..410 91/132 (69%)
4 X approximate repeats 279..346 44/66 (67%)
Interaction with PPIB. /evidence=ECO:0000250 327..360 21/32 (66%)
4 X approximate repeats 349..406 41/56 (73%)
Sufficient to mediate interaction with SGIP1. /evidence=ECO:0000269|PubMed:21747946 504..591 34/106 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..591 31/89 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835703
Domainoid 1 1.000 502 1.000 Domainoid score I343
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1324
Inparanoid 1 1.050 561 1.000 Inparanoid score I1087
Isobase 1 0.950 - 0 Normalized mean entropy S1544
OMA 1 1.010 - - QHG48587
OrthoDB 1 1.010 - - D230478at33208
OrthoFinder 1 1.000 - - FOG0001260
OrthoInspector 1 1.000 - - mtm8849
orthoMCL 1 0.900 - - OOG6_102144
Panther 1 1.100 - - O PTHR11073
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R163
SonicParanoid 1 1.000 - - X875
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1615.890

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