Protein Alignment Cnx99A and CLGN

DIOPT Version :10

• Sequence 1: NP_477157.1
• Gene: Cnx99A / 44643
• FlyBaseID: FBgn0015622
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_004353.1
• Gene: CLGN / 1047
• HGNCID: 2060
• Length: 610
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 278/619 - (44%)
• Similarity: 374/619 - (60%)
• Gaps: 44/619 - (7%)

  Fly    13 LALLFASSLLLLSAANAADLDTESDDFEDGYVE-DVQEEPAVIGGDEKLAYESPVIDAKKFHFAD 76
            |.|||.|     ..|...|.|.|::|||:...| ||.|...    ..::.|::|. ...:.:||:
Human    10 LGLLFIS-----INAEFMDDDVETEDFEENSEEIDVNESEL----SSEIKYKTPQ-PIGEVYFAE 64

  Fly    77 HFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIAAPLR 141
            .||....:  .||||:|||||:.||||.|||.|..|..:......|.||||||:|||.||:|.|.
Human    65 TFDSGRLA--GWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLA 127

  Fly   142 KPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQ--LKAFNDKTPYTIMFGPDKCGND 204
            |||.| :||||:|||||..|:|.:|||:|:|||:   ||:.  |:.|.|||.|.|||||||||.|
Human   128 KPFIF-ADKPLIVQYEVNFQDGIDCGGAYIKLLA---DTDDLILENFYDKTSYIIMFGPDKCGED 188

  Fly   205 VKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEGSL 269
            .|:||||||.:|..|...|||...|...|::.|.|:..|||.||:.||::||:.||..::|:|||
Human   189 YKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSL 253

  Fly   270 LTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDE 334
            |.|..||:.||.||:||||.|||.||||.|||||:|.|||||||..|.|:.|:..|.|.|||:||
Human   254 LEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDE 318

  Fly   335 PDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPN 399
            |..|.||.|.||:||:.:.|||||||.:.||.|.  .|||:||.|:|.||.|||.||.|:::|||
Human   319 PKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACR--IGCGEWKPPMIDNPKYKGVWRPPLVDNPN 381

  Fly   400 YQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDI 464
            |||.|:||||||||:|||..||.:|..||:|||||||:|||.|||.||..:.|||..:||:.:..
Human   382 YQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRW 446

  Fly   465 KRRYIDRESDSFVNKVVELAKANPSIWGIGLV-AIVALVALTIYC--RFGTAKSQDSAAK----- 521
            |....:......:.:::..|:.:|.:|.|.|| |.|.:..:|.:|  |....|.:|:..|
Human   447 KIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTAGVPIALITSFCWPRKVKKKHKDTEYKKTDIC 511

  Fly   522 ----KAAAEAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSDLDDNEEES--- 579
                |...|.::.::....::|...||..::..|:..::........|..::.::.:.:|||
Human   512 IPQTKGVLEQEEKEEKAALEKPMDLEEEKKQNDGEMLEKEEESEPEEKSEEEIEIIEGQEESNQS 576

  Fly   580 -KAAESREPAQTEESN-------TKTRKRQARKE 605
             |:....|..:.:||.       ...|||:.||:
Human   577 NKSGSEDEMKEADESTGSGDGPIKSVRKRRVRKD 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_477157.1	Calreticulin	74..447	CDD:459737	219/374 (59%)
CLGN	NP_004353.1	Calreticulin	62..429	CDD:459737	219/374 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..338		49/79 (62%)
		Interaction with PPIB. /evidence=ECO:0000250	317..350		19/32 (59%)
		2-1	339..352		8/12 (67%)
		2-2	356..369		7/12 (58%)
		2-3	370..383		7/12 (58%)
		2-4	384..397		10/12 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..610		16/88 (18%)