DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cnx99A and si:ch211-274f20.2

DIOPT Version :9

Sequence 1:	NP_001036767.1	Gene:	Cnx99A / 44643	FlyBaseID:	FBgn0015622	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_001344439.4	Gene:	si:ch211-274f20.2 / 100005358	ZFINID:	ZDB-GENE-091204-91	Length:	452	Species:	Danio rerio

Alignment Length:	505	Identity:	167/505 - (33%)
Similarity:	241/505 - (47%)	Gaps:	103/505 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 HFADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIA 137
            :||:.||:....|| ||||:|    :.:.: :|:|.|..|...:.....:.||||||..:|.||:
Zfish    39 YFAETFDEGALDRK-WVLSKA----VVKHL-RYNGEWAVEESIQPRLLGNKGLVLKSPGRHHAIS 97

  Fly   138 APLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDKTPYTIMFGPDKCG 202
            |.||..:.|| ||||::||||:.|:|.:|||:|:||||...|. :|..|:|.||||||||||||.
Zfish    98 AYLRNIYHFK-DKPLILQYEVSFQKGIDCGGAYIKLLSQSDDL-RLSQFSDATPYTIMFGPDKCS 160

  Fly   203 NDVKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEG 267
            ::.|:||||.|.|||..|..|||..:|:..|.:.|.|:..|||.|.:.|||:|||.||..:||:|
Zfish   161 SNHKIHFIFSHHNPITRTYEEKHARQPEMDLSDYFTDQQAHLYTLNLYPDNTFEILVDLTLINKG 225

  Fly   268 SLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLE 332
            |||.|...||   |..|...:|              ..::..|                    |.
Zfish   226 SLLEDMDTPV---ASSDQKQEH--------------LTNEASD--------------------LN 253

  Fly   333 DEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIEN 397
            .|..|..|....:..|                  |.:|..|.....|.....|           |
Zfish   254 LEQHMRSDGVDRQRND------------------CTEASVCEGSSRPASSGSN-----------N 289

  Fly   398 PNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSF 462
            |..|    |....|....:..:.|.|:||:|||.||||::.|::|||:::.||:||||.:..:::
Zfish   290 PKNQ----PSTNTNDKDNKGKQQFTMSPIAAVGFELWSLTGDVMFDNILLCDDLEVARRWTEDTW 350

  Fly   463 DIKRRYIDRESDSFVNKVVELAKANPSIWG-----IGLVAIVALVALTIYCRFGTAKSQDSAAKK 522
            .      .|::...:.|::......|.:||     :||..|:.:..:....||| ...||
Zfish   351 G------QRQTPGMIEKLLMATVKRPWLWGVYVFTVGLPIILFVSLMWPDKRFG-PPDQD----- 403

  Fly   523 AAAEAKKSDDPQPDDEPEAEE----ESDERAAGDTSKESTPLSASPKKNQ 568
              ...||:|:||.|...:.||    :..|....:|  :|..:..:||..:
Zfish   404 --YYYKKTDEPQTDGPQDVEEHVTHDHGENQRVET--KSRVVKRAPKNTE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_001036767.1	Calreticulin	74..447	CDD:278680	135/372 (36%)
si:ch211-274f20.2	XP_001344439.4	Calreticulin	40..335	CDD:306718	135/372 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850