DRSC/TRiP Functional Genomics Resources

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Protein Alignment Apc and apc

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:XP_002936457.1 Gene:apc / 779466 XenbaseID:XB-GENE-480855 Length:2833 Species:Xenopus tropicalis


Alignment Length:2931 Identity:720/2931 - (24%)
Similarity:1067/2931 - (36%) Gaps:1026/2931 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 VDSVPERKPHFLDYDAVPPP-DYE-EGFGASSGEQL----KMDKKYE-RDGEVSDYELAASGYTK 81
            :||:|..:...|..|..... :|| ....|:..|||    .|:|:.: |.|::...|        
 Frog   169 IDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRVQTRVGKIQQIE-------- 225

  Fly    82 KEFTQDDNTLHFTQSAVGLGSGAVGKKPAAKHFLDENPIPPDYMLAQELREMREHRSLDRNFERQ 146
                  ::.|...|......:.|..:.|.:||                                 
 Frog   226 ------EDILRIRQLLQSQAAEAAERTPQSKH--------------------------------- 251

  Fly   147 SAQQQQLDELPPRNG-----GGSPASAGRPSRSKEPSYTLSRFLDGDAPAPAPRLPKGAAWTTSF 206
            .|..:..|:||...|     ..|...:|:.|.|:....|.| .:..::....||           
 Frog   252 DAGSRDADKLPDGQGTSEIVTSSNVGSGQGSSSRADHDTAS-VMSSNSTYSVPR----------- 304

  Fly   207 DERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQMM 271
              |.||.     ||:|||.|||||||||::|..:|::..|.:|.:..||..:|:|||:|||:|::
 Frog   305 --RLTSH-----LGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCIAMRQSGCLPLLIQLL 362

  Fly   272 HAPDND----------QEVRKCAGQALHNVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQ 326
            |..|.|          :|.|..|..||||::||.||:|.||||.:||.||:||..||.......:
 Frog   363 HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQE 427

  Fly   327 SGGEAIADDSDRHPL---------AAISSLMKVSFDEEHRHAMCELGALHAIPNLVHLDHAVHGP 382
            :..:.:  |.|::|:         .|:..|||:||||||||||.|||.|.||..|:.:|..::| 
 Frog   428 AHEQGM--DQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYG- 489

  Fly   383 KPEDQCCNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLDSAPDDLLQVTASVLRNLS 447
            ...|....:|||||.||||||||||..|||.||..|..|.||||||.|..:||.||.||||||||
 Frog   490 LINDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKSCMRALVAQLKSESEDLQQVIASVLRNLS 554

  Fly   448 WRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLV 512
            ||||.|.|..|.|:|:|.||...|:..:.|:|||::|||||||||||:.|||:.|:|||||||||
 Frog   555 WRADVNSKKTLREVGSVKALMECALDVKKESTLKSVLSALWNLSAHCTENKADICSVDGALAFLV 619

  Fly   513 GMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAILLQQLKSESLTVVSNSCG 577
            |.|:|...:.||.|||:.|||||||||.||..|.:|||||::|||..|||.|||.|||:|||:||
 Frog   620 GTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACG 684

  Fly   578 TLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNHHQLDPIAR 642
            ||||||||:|:||:.|||.|||.||::||||||.||:.||::||:||:..|||...    |....
 Frog   685 TLWNLSARNAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYK----DANIM 745

  Fly   643 SMGLKALPTLEARKAKALQQELGERHTAETCDNLD------------------------------ 677
            |.| .::|:|..||.|||:.||..:|.:||.||:|                              
 Frog   746 SPG-SSVPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTTHRNKQRHKQNLCSEYVLDSSRHD 809

  Fly   678 ---------TGGKL-----------------------------DKERASSSSRRHPAP------- 697
                     :.|.|                             |:||.:..|..|.|.       
 Frog   810 DSICRSDNFSLGNLTVLSPYINSTVLPGSSSPRPTMEGNRPEKDRERTAGLSNYHSATENSGNSS 874

  Fly   698 -----RLTRSAMLTK-----------SESRDSVYSAKSDCAYDH--------------------- 725
                 :|:.:|.::|           .|.|.|..:::..|..|.                     
 Frog   875 KRIGVQLSTTAQISKVMDEVSNIHMVQEDRSSGSASEMHCMSDERTSQRKPSSNHPHSNPFSFAK 939

  Fly   726 -----------------------LIRSASASDAHRK---VKPKITDFDLEME------------- 751
                                   .:.|.|::|.:.|   |||.:..:..:.|             
 Frog   940 GDSSNRGCPVAFMKMEYKMASNDSLNSVSSTDGYGKRGQVKPSVESYSEDDEGKFGSYGHYPAGL 1004

  Fly   752 ----------QDTEATEEQPIDYSVKYSE-----------------------------------N 771
                      .|.:...:.||:||:|||:                                   .
 Frog  1005 AHKIHSANHMDDNDTELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIDSEMKQSEQRQPR 1069

  Fly   772 ATKT--STYQET----------------------------------------------------- 781
            .|||  |:|.|.                                                     
 Frog  1070 TTKTTYSSYTENKEEKHKKFPPHFNQPENAPAYARSRGTNNQADQSRVGSNLSNNSKASKPHCQV 1134

  Fly   782 ---DLDQPTDFSLRYAENQIESDLDISGPAGGQKSTITPPAETVPEKSEGQEILLILDDSVKCYQ 843
               |.|:.|:||.||:|.:.:.|.:    ....|..|.|.|.   ::..|::.:    |..:.|.
 Frog  1135 DDYDDDKTTNFSERYSEGEQQEDEN----ERQNKYNIKPYAS---DEHHGEQPI----DYSRKYP 1188

  Fly   844 TEDTP-------YVISNAASVTDLRVAAKADAEAEVKPEVREVTSKEGAPK-------------- 887
            | |.|       :..||..|              :.||:..:|:|....|.              
 Frog  1189 T-DVPSSAQKPSFPYSNNPS--------------KQKPKKEQVSSSSNTPTPSPNSGRQNQLHPN 1238

  Fly   888 --------KLPKLSQCGSGSYTPEKPINYCEEGTPGYFSRYDSLSSL----DE------------ 928
                    ..||.:.....|.|.|....||.|.||..|||..|||||    ||            
 Frog  1239 SAQTRPGLNRPKQTSSKPPSITQETIQTYCVEDTPICFSRGSSLSSLSSAEDEIEGRERSSRGQE 1303

  Fly   929 --------SGKANQAIVGTD----------------------ADIKP---------KLEKQEEQE 954
                    ..|.|::.|..|                      ::|.|         :.....:..
 Frog  1304 SNNTLQITEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKSP 1368

  Fly   955 SQPAEQVLTKPPTQANSALETPLMFSRRSSMDSLVHDPDVDVANCDDKSSVVSDFSRLASGVISP 1019
            |:...|....||  .:...||||||||.:|:.||.......:|: ...|||.|:  .:.||:|||
 Frog  1369 SKSGAQTPKSPP--EHYVQETPLMFSRCTSVSSLDSFESHSIAS-SIASSVASE--HMISGIISP 1428

  Fly  1020 SEIPDSPTQSMPQSPRRNSVAGSGQNV-----DSPPVV-------------IPASLQPLRSVFE- 1065
            |::||||.|:||  |.|:......|.|     .|.|.|             :.:::|.::.:.| 
 Frog  1429 SDLPDSPGQTMP--PSRSKTPPPPQTVHAKKDSSKPKVSGEERDKVAKQTGVHSAIQRVQVLQEA 1491

  Fly  1066 DDLSSFNVEHTPAQFSTATSLSNLSIVDDE---------KAPASVAEED--NEDELLLANCINMG 1119
            |.|..|..|.||..||.|:|||.||:  ||         |....|.|.|  ||.|....:..|:.
 Frog  1492 DTLLHFATESTPDGFSCASSLSALSL--DEPYIQKDVELKIMPPVLENDQGNEAEPEKESTDNLN 1554

  Fly  1120 -MQRKPTEAVKSTV--VNSEVDVAEETIRSYCTEDTPALLSKVPSNTNLSVISMSSTDPKDATAG 1181
             .:.|.:|..|..:  .:.::|:.||.|.|        .:.:.||..|..|...::..|....| 
 Frog  1555 KKENKRSEQEKDMLDDTDDDIDILEECIIS--------AMPRKPSRKNKKVPQPTAGKPPPPVA- 1610

  Fly  1182 QAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGMKKPLGEATSDPIAMLRRGGNELP-----G 1241
                                                :||    :..|:..|....|.|.     .
 Frog  1611 ------------------------------------RKP----SQLPVYKLLSSQNRLQTQKHVN 1635

  Fly  1242 YLPSADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLVGPAVQLKETEPSSADQNPEMKAKPGKQEQ 1306
            :..|.|....:.||.:|.|||..:.||:||:.|.   |.......:|::...:.:::    |::.
 Frog  1636 FTHSDDMPRVYCVEGTPINFSTATSLSDLTIESP---PNELTNNDQPNTGSLSTDLE----KRDT 1693

  Fly  1307 VRRPPHWQDD---------SLSSLSIDSEDDTNLLSQAIAAGCNRPKSNLGFSSNGKRSSSLSSS 1362
            :.......||         |.|.|..|..::.::|::.|.:...:.||:..:             
 Frog  1694 IPTEGRSTDDTDASKKLNPSTSVLDEDKAEEGDILAECIHSAMPKGKSHKPY------------- 1745

  Fly  1363 QPIAINAATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQSKSLFELCILKGMYKTKEPGARAQ 1427
                              .|:|...|.:::|..:|..|:                         :
 Frog  1746 ------------------RVKKIMDQINHTSAGTSSGNN-------------------------R 1767

  Fly  1428 QMQEQPIVGSSSVQSNPSLKQFDSLPVQLPSSGQVKRQRHHHHHHHHRERERERKDEKLLQECIN 1492
            .|||        :..|........:|..:...|::|:   :.....:...|.:..|.: .|...|
 Frog  1768 SMQE--------IDKNKPTSPVKPMPQSIEFKGRLKK---NTESKLNPSSENQYSDPR-KQNSKN 1820

  Fly  1493 TGISKKIN-AVPKNVLATSAAALEPCH---PMAAT-------TSASALSTAAPDVE---QKAHAT 1543
            |  ||..| .:|.|...|...|.:..|   |:..|       .|.|:|.....|::   :||.. 
 Frog  1821 T--SKDANEKIPNNEERTKGFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDIDLSKEKAEL- 1882

  Fly  1544 SNPQQQSSTHPSSHILPNPIDAIATVTDTVRSPAAPNQGNGNASQNGLETATGSKDLD------- 1601
               :::..|                 .||.|.....|: |...:|.|.:...|.|.|:       
 Frog  1883 ---RKEKGT-----------------KDTDRKGKYKNE-NPAINQIGKQEQVGPKSLEGRGQPKA 1926

  Fly  1602 --------------SEDR--SSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKSVER 1650
                          ::||  :.||..|:|.:|.        ...|.|                  
 Frog  1927 LVHKPTSFCPAAKGTQDRGGAKDEKMQNFAIEN--------TPVCFS------------------ 1965

  Fly  1651 LTMEFVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSF----PSVSQTAP-------- 1703
                        |:||.:..|....:||:......:.|...:...    |..|..||        
 Frog  1966 ------------RNSSLSSLSDIDQENNNKETEPIKQTEMTETQIGLRRPQTSGYAPKSFHVEDT 2018

  Fly  1704 --------VLASLSLDEDATEARSLHELIEITPTNEQQPESLEGETDTLVNGHADSYSGSSGGLN 1760
                    .|:|||:|   :|...|.|.|......:::|...:.|.:       .|.|.|.||  
 Frog  2019 PVCFSRNSSLSSLSID---SEDDLLQECISSAMPKKKKPSKAKNEGE-------KSSSNSVGG-- 2071

  Fly  1761 FQLGGQVQNAGVRLEPQRLLFNGTSASIMTNSTMIAFEARAL----AENLLQPAATDDDTTEMTF 1821
                                       |:.....:..:.|.|    :||...|.:.:.|...:..
 Frog  2072 ---------------------------ILAEEPDLTLDLRDLQSPDSENAFSPDSENFDWKAIQE 2109

  Fly  1822 SLNSLDLDNIRPPSGMESLN-SCYQDHSQPSSLRQAMPSKSPRFARKMFPANLVARRALGHLAGS 1885
            ..||: :..:...:...||: ....|.....||:..:...||                 .||...
 Frog  2110 GANSI-VSRLHQAAAAGSLSRQGSSDSDSILSLKSGISLGSP-----------------FHLTSD 2156

  Fly  1886 AESVNSSCNLLDNIKPPSLMDELLDSMISVDSIQSE---VADGEQDC-SMATTISVSNYE-TAAC 1945
            .|....:||     |.|.::.....|.:.....:.|   :..|::.. |:.|..|.|:.: ::.|
 Frog  2157 KEEKTITCN-----KGPKIVKPSDKSALENKKTEDEPKGIKGGKKVYKSLITGKSRSSSDFSSHC 2216

  Fly  1946 DDQTMTVLQSCFDEDEDATMNDY-----SSAESTPKHGSTP-SPNRRSLTPKDKRRLTKDRFKTY 2004
            .....|.:.|.   ....||...     ||..::|.....| ..|..|.:|.:.:.|:       
 Frog  2217 KQSVQTNMPSI---SRGRTMIHIPGVRASSPSTSPVSKKGPVFKNAPSKSPNENQSLS------- 2271

  Fly  2005 TIATSCEMEAPEANETLQIEIVEAAVPVATPSPRANGR-RRGSAERYKTQLIECPLALIQPQPDD 2068
                    .:|:.::.|:.|....:...:|....:.|. |.||.:.            :..:|. 
 Frog  2272 --------NSPKGSKPLKSESFYGSRQSSTSGGSSKGNSRSGSRDS------------VSSRPS- 2315

  Fly  2069 CPSEQLSSIRAMMQQFTFITDINIGHSQETCESTDHPEDAGESPECDQNSETESCDGQEPDQLPP 2133
              |:|||  |.:                             :||  .:||.:...:|     :.|
 Frog  2316 --SQQLS--RPL-----------------------------QSP--GRNSISPGRNG-----ISP 2340

  Fly  2134 PPSIVDLRTSVVKPTTLEPATAVKLVRGRKKPAYVSPYSMQSQRNSN------------------ 2180
            |.....|      |.|..|:||.....|..:.:|.||....||.|.:                  
 Frog  2341 PNKFSQL------PRTSSPSTASTKSSGSGRMSYTSPGRQLSQPNLSKQSGLPKTPSSIPRSESA 2399

  Fly  2181 --------NAAPSKKKTLSPTIAKRSLVPGGSGVRLPAKKKPTPPPEPAPARLERQGTFVK---- 2233
                    |..|:||..||...:.:|     ||......::|.         |.||.||:|    
 Frog  2400 SKGLNQNVNTGPNKKVELSRMSSTKS-----SGSESDRSERPA---------LVRQSTFIKEAPS 2450

  Fly  2234 ----------------------DEPTNSNVQVPVVE-TKPAQTSPTHRAS-----KLPTKKGTAS 2270
                                  |.||.|..|.|.:. :.|..:..||...     |:|.....|:
 Frog  2451 PTLRRKLEESASFESLSSSSRADSPTRSQTQTPALSPSLPDMSLSTHSIQAGGWRKMPPNLNPAA 2515

  Fly  2271 GG---------SPSKAGSPKRIPLAPARRMTPQRANTSLRLAAGKSHAASRVVSGRVSSTTPPSR 2326
            ..         |.|.:.||.|:|:.        |:.|..|..:..|.:..||      ||...:.
 Frog  2516 EHGDSRRRHDISRSHSESPSRLPIT--------RSGTWKREHSKHSSSLPRV------STWRRTG 2566

  Fly  2327 SNSNLNGSSAAAAAAAKINHAQSRIANIWKRVDEAKTKQSSSNLRT-QKTKSSNMLN--ANGTKP 2388
            |:|::..:|:.::..||....:.::.:..    ..|::.|||...| :|.|.|.:|.  :||:..
 Frog  2567 SSSSILSASSESSEKAKSEDEKQQVCSFL----GPKSECSSSAKGTWRKIKESEILETPSNGSSN 2627

  Fly  2389 TLLRSS 2394
            |:..||
 Frog  2628 TIAESS 2633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 51/103 (50%)
armadillo repeat 258..332 CDD:293788 35/83 (42%)
ARM 332..448 CDD:237987 67/124 (54%)
armadillo repeat 369..403 CDD:293788 14/33 (42%)
armadillo repeat 411..448 CDD:293788 24/36 (67%)
armadillo repeat 498..539 CDD:293788 27/40 (68%)
ARM 506..624 CDD:237987 80/117 (68%)
armadillo repeat 548..582 CDD:293788 25/33 (76%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 8/29 (28%)
APC_crr 903..927 CDD:283553 14/27 (52%)
APC_crr 1066..1090 CDD:283553 12/23 (52%)
APC_crr 1247..1271 CDD:283553 9/23 (39%)
apcXP_002936457.1 APC_N_CC 4..55 CDD:374728
Suppressor_APC <157..207 CDD:371516 11/37 (30%)
ARM 342..394 CDD:214547 20/51 (39%)
APC_rep 395..468 CDD:376216 31/74 (42%)
ARM 461..512 CDD:214547 29/51 (57%)
armadillo repeat 467..510 CDD:293788 21/43 (49%)
ARM 514..555 CDD:214547 26/40 (65%)
armadillo repeat 518..555 CDD:293788 24/36 (67%)
armadillo repeat 565..597 CDD:293788 16/31 (52%)
armadillo repeat 605..646 CDD:293788 27/40 (68%)
Sec7_N 607..>689 CDD:372313 55/81 (68%)
ARM 651..691 CDD:214547 28/39 (72%)
armadillo repeat 655..689 CDD:293788 25/33 (76%)
Arm 693..731 CDD:366143 23/37 (62%)
armadillo repeat 697..733 CDD:293788 23/35 (66%)
Arm_APC_u3 734..1018 CDD:374686 46/288 (16%)
APC_u5 1036..1137 CDD:374687 6/100 (6%)
APC_u9 1288..1375 CDD:374689 9/86 (10%)
PTZ00449 <1311..1699 CDD:185628 108/452 (24%)
APC_r 1641..1664 CDD:368672 9/22 (41%)
APC_u13 1666..1719 CDD:374690 9/59 (15%)
APC_u14 1750..1838 CDD:374691 22/126 (17%)
APC_u15 1874..1947 CDD:374692 15/94 (16%)
APC_basic 2226..2566 CDD:368684 87/444 (20%)
EB1_binding 2668..2833 CDD:368678
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 202 1.000 Domainoid score I2930
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 617 1.000 Inparanoid score I875
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm9548
Panther 1 1.100 - - O PTHR12607
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.060

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