DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Apc and pkp2

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	NP_001106904.1	Gene:	pkp2 / 568060	ZFINID:	ZDB-GENE-041210-167	Length:	815	Species:	Danio rerio

Alignment Length:	793	Identity:	160/793 - (20%)
Similarity:	272/793 - (34%)	Gaps:	252/793 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AELSLEDVDVDSVPERKPHFLDYDAVPPPDYEEGFGASSGEQLKMDKKYERDGEVSDYELAASGY 79
            |..||..||....|          ::.||.:..|:|:..                         |
Zfish   123 ATRSLRMVDRSQWP----------SMEPPLFHRGYGSFR-------------------------Y 152

  Fly    80 TKKEFTQDDNTLHFTQSAVGLGSGA--VGKKPAAKHFLDENPIPPDYMLAQELREMREHRSLDRN 142
            |.|            ::.:.|||.:  :...|...|| ..|.:|..|..::.||..|
Zfish   153 TPK------------RAGLCLGSNSLTLPSAPTTSHF-QMNKLPLRYAHSEVLRNPR-------- 196

  Fly   143 FERQSAQQQ----QLDELPPRNGGGS---PASAGRPSRSKEPSYTLSRFLDGDAPAPAPRLPKGA 200
            |...||..|    .:.|.|..:....   |:::....|.:...:||.:.|..........|.:..
Zfish   197 FAGLSAATQIPSSPVYENPHTDDTDDVFLPSTSVERGRMESEKHTLQQTLCKQREGGFVALEQSE 261

  Fly   201 AWTTSFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSG--- 262
              ..|:..|....::|...|.:.....||:||...:..|...:| ||:..:|  ..||.:.|
Zfish   262 --NVSWQSRVRKPSLEFVAGRRPSQTGSLISMEEQSGSLGRIEK-LEVKQHA--VTTLTKKGKPG 321

  Fly   263 ----------CMPLLVQMMHAPDNDQEVRKCAGQALHNVVHSHPDEKAGRREAKVLRLLDQIVDY 317
                      .:.||.|     ||:.|.:..|...:.|...:.||.|     .|:|.|
Zfish   322 ELSAEMTLKEAVNLLTQ-----DNNMETQIAAANFIQNQCFNSPDAK-----RKILHL------- 369

  Fly   318 CSFLKTLLQSGGEAIADDSDRHPLAAISSLMKVSFD-EEHRHAMCELGALHAIPNLVHLDHAVHG 381
             ..:..||    :.:.:||:....||:|||..:.|: .|::..:.:...|..|..|:.::..:..
Zfish   370 -QGIPKLL----KLMQNDSEELQWAAVSSLRNIVFENNENKMEVKDCEGLPVILRLLKINRDIET 429

  Fly   382 PK----------PEDQCCNSLRRYALMALTN--------LTFGDENNKALLCGQKQFMEA--LVA 426
            .:          ..|.....|.|.|:..||:        ::.|::....||.....|..|  .:.
Zfish   430 RRQLTGLLWNLSSHDLLKEHLSREAVKPLTDSVLVPCSGISEGEDPKLELLADPDIFYNATGCLR 494

  Fly   427 QLDSA------------------------------PDD-LLQVTASVLRNLSWRAD--------- 451
            .|.||                              ||| ..:....:|.|||:|.|
Zfish   495 NLSSAGPDGRKVMRDCEGLIECVIYYIRGTIADYKPDDKATENCVCILHNLSYRFDCEVPRVDSP 559

  Fly   452 ---------------------------SNMKA-----VLNEIGT----------VTA---LALAA 471
                                       .|::|     .|.|.|:          :|.   |:|.|
Zfish   560 VAQKPKQTHTETSNPGCFIIKTPKNSAENLEADEDYPALEENGSPHGVEWLWSAITVRMYLSLIA 624

  Fly   472 MRNRSENTLKAILSALWNLSAHCSTNKAEFCA-----VDGALAFLVGMLSYEGPSKTLKIIENAG 531
            : :.:::|.:|.:..|.||:| ||...::..|     .:|.|: .|..|..|...:.|:|   :.
Zfish   625 V-STNQHTKQASIGTLQNLTA-CSGEISQAIAHFIVQKEGGLS-QVKKLLQEAEKEELRI---SV 683

  Fly   532 GILRNVSSHIAVCEPYRQILRQHNCLAILLQQLKSESLTVVSNS--------------CGTLWNL 582
            .:|:|:|.       ||::   |   |.:::|:..|.:.::.||              |..|.||
Zfish   684 SLLKNISR-------YREL---H---ADIVKQVLPELVAILPNSDRNVEQPIEITVTICHILINL 735

  Fly   583 SARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLK 647
            |..||.:...:.:.||:|.:.|:....:......:..|...||:   .:..|.:|....:..|.:
Zfish   736 SQASASNTCAIINQGALPKIISISSKDNGFGPTRAGQAACVLLH---TLWRHSELHSSFKKAGYR 797

  Fly   648 ALPTLEARKAKAL 660
            ....:..|..||:
Zfish   798 KTDFINNRTVKAV 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	26/106 (25%)
		armadillo repeat	258..332	CDD:293788	18/86 (21%)
		ARM	332..448	CDD:237987	32/167 (19%)
		armadillo repeat	369..403	CDD:293788	8/51 (16%)
		armadillo repeat	411..448	CDD:293788	13/69 (19%)
		armadillo repeat	498..539	CDD:293788	10/45 (22%)
		ARM	506..624	CDD:237987	30/131 (23%)
		armadillo repeat	548..582	CDD:293788	9/47 (19%)
		armadillo repeat	590..624	CDD:293788	5/33 (15%)
		APC_crr	837..860	CDD:283553
		APC_crr	903..927	CDD:283553
		APC_crr	1066..1090	CDD:283553
		APC_crr	1247..1271	CDD:283553
pkp2	NP_001106904.1	ARM	326..442	CDD:237987	28/137 (20%)
		armadillo repeat	329..355	CDD:293788	7/30 (23%)
		armadillo repeat	363..399	CDD:293788	13/52 (25%)
		armadillo repeat	405..440	CDD:293788	3/34 (9%)
		armadillo repeat	455..496	CDD:293788	7/40 (18%)
		armadillo repeat	657..689	CDD:293788	8/35 (23%)
		ARM	658..763	CDD:237987	29/121 (24%)
		armadillo repeat	696..737	CDD:293788	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910