DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and apc2

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	XP_021335660.1	Gene:	apc2 / 565771	ZFINID:	ZDB-GENE-090422-1	Length:	2119	Species:	Danio rerio

Alignment Length:	2062	Identity:	537/2062 - (26%)
Similarity:	828/2062 - (40%)	Gaps:	581/2062 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 AQELREMREHR--SLDRNFERQSAQQQQLDELPPRNGGGSPASAGRPSRSKEPSYTLSRFLDGDA 189
            ||:||.:.|.|  :.|...:|...:..:|::| .:....:.:|.|...:|..|....:..|   .
Zfish   219 AQQLRSVMEERFGTSDEMVQRTQIRVARLEQL-EKELHDAQSSRGPQEKSALPETQSTECL---P 279

  Fly   190 PAPAPRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQS 254
            .|..|.|..|.|.|..         .....|||||.|:.|||||.|.|..||::..|.:|.:.:|
Zfish   280 KASVPDLDTGNAGTLD---------APGEAGSKVEMVFWLLSMLASRDREEMSRTLLAMSSSQES 335

  Fly   255 CATLRRSGCMPLLVQMMHAPDN---------DQEVRKCAGQALHNVVHSHPDEKAGRREAKVLRL 310
            |..:|:|||:|||||::|....         .:|.|..|..||||:|:|.|||...|||.:||.:
Zfish   336 CIAMRKSGCVPLLVQILHEGGTGEAAGTGCYSREARSRASAALHNIVYSQPDEGQARREMRVLHV 400

  Fly   311 LDQIVDYC--------SFLKTLLQSGGEA--IADDSDRHPLAAISSLMKVSFDEEHRHAMCELGA 365
            |:||..:|        :.|.|....|.:.  |.:..|.....|:.::||:||:||:|.||.|||.
Zfish   401 LEQIRSHCENGWDWIENHLSTPSPGGSKTTEIPEPVDPQICQALCAIMKLSFEEEYRRAMNELGG 465

  Fly   366 LHAIPNLVHLDHAVHGPKPEDQCCN-SLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLD 429
            |.||..|:.||..::|...|.  .| :|||||.||:||||:||..|||.||.:|..::|:||||.
Zfish   466 LQAIAELMQLDQELYGMHNEP--INMALRRYAGMAVTNLTYGDVVNKATLCSKKNCLQAIVAQLA 528

  Fly   430 SAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHC 494
            |..::|.||.:|:|||||||||.|.|..|.::|:|:.|...|::...|:|||::||||||||||.
Zfish   529 SDSEELQQVVSSILRNLSWRADINSKRALRDVGSVSGLMTCALQATKESTLKSVLSALWNLSAHS 593

  Fly   495 STNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAI 559
            :.||...|:|||||.|||..|:|...:.:|.|||:.|||||||||.||..:.||||||.||||..
Zfish   594 TENKVAICSVDGALGFLVSTLTYRCQTNSLAIIESGGGILRNVSSLIATRDDYRQILRDHNCLQT 658

  Fly   560 LLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNL 624
            |||.|:|.|||:|||:|||||||||||.:||:.|||.|||.|||:||:|||.||:.||::||:||
Zfish   659 LLQHLRSHSLTIVSNACGTLWNLSARSPKDQELLWDLGAVSMLRNLINSKHKMIAMGSAAALRNL 723

  Fly   625 LNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLDTGG--------- 680
            |..||....    |....|.| ..:|:|..||.|||:.||..:|.|||.|.|:...
Zfish   724 LTNRPLKYK----DAAVISPG-SCMPSLYMRKQKALEAELDAKHLAETFDTLEKQSFKHANINKP 783

  Fly   681 -----KLDKERASSSS--RRHPAPRLTRS------AMLT----------------KSESRDSVYS 716
                 .|.|:.||.|.  ....||.::.|      :||:                :.|....:.:
Zfish   784 LRHIESLAKDYASDSGCFDDDEAPNVSTSLDTGTFSMLSMFLNNSNFLNTQLRKREGEPEQDIET 848

  Fly   717 AKSDCAYDHLIRSASASD----AHRKVKPKITDF---------DLEMEQDTE-----ATEEQPID 763
            .::|     :.||....|    |..|:..|||:.         |:.|...:|     ::|:..:|
Zfish   849 FQTD-----IKRSQPPDDEVTVAAEKLAKKITNTVAKIDKLVDDITMHTSSEDSFSLSSEDHFLD 908

  Fly   764 YSVKYSE-NATKTSTYQETDLDQPTDFS-------------LRYAENQIESDLDISGP-----AG 809
            ::....| :..:..:.....|...:.||             |:...:.:.:|...||.     .|
Zfish   909 WNYGPDELHEARAISCSPCPLSDSSTFSPKERLSRAHAFMRLKTTNSSLSNDSLNSGSISDGYCG 973

  Fly   810 GQKST--ITPPAE------------------------------TVPEKS-EGQEILLILDDSVKC 841
            .|..|  ...|.|                              .:||:. |..:..::.|.....
Zfish   974 SQDQTHPSARPTEQRRPNKLDLKVAHEEPLTSGVHISRVLCQNEIPERDFEANKDAILPDSGSTD 1038

  Fly   842 YQTEDTPYVISNAASVTDLRVAAKADAEAEVKPEVR-----------EVTSKEGAPKK------- 888
            .:....|::.:.|.      |:.|..:|..: |.|:           :..:|.|..|.
Zfish  1039 TEKSQEPFISTPAT------VSTKVSSETSI-PTVKLSPSYQHVPLIQSVAKFGVAKTAINVQAA 1096

  Fly   889 --------LPKLSQCGS-GSYTP------------EKPINYCEEGTPGYFSRYDSLSSLD----- 927
                    :|.:...|| ..::|            |.|..|..|.||..|||..|||||.
Zfish  1097 QAMRRQAWVPAVMTGGSISKFSPICSARSPTIGQLETPQKYSVENTPICFSRCSSLSSLSSGDGA 1161

  Fly   928 -----------ESGKANQAIVGTDADIKPKLEKQEEQ------------------ESQPAE---- 959
                       ||..:.:.|...|.:::.|.|:.|.:                  .|.|.|
Zfish  1162 LDGQSQTENELESDSSLEIIEVEDVNVERKDEEDENETLDDLSDSQLLVTDQKISSSDPIEISGT 1226

  Fly   960 ------------QVLTKPPTQANSA----LETPLMFSRRSSMDSLVHDPDVDVANCDDKSSVVSD 1008
                        .|:.:..|.::|:    .||||:.||.||:.||.......:|     ||:.||
Zfish  1227 IKNEKRFLRGVSPVILEDRTPSSSSDNYIHETPLVMSRCSSVSSLGSFESPSIA-----SSIQSD 1286

  Fly  1009 -FSRLASGVISPSEIPDSPTQSMPQSPRR-----NSVAGSGQNVDSPPVVIPASLQPLRSVFE-- 1065
             .|.:.||.:|||::||||.|:||.|..:     .|.....||:........:||:....:.:
Zfish  1287 PCSEMISGTVSPSDLPDSPGQTMPPSRSKTPCCPESGGADAQNLSGVGSQWESSLRKFMEIADFK 1351

  Fly  1066 ---------DDLSSFNVEHTPAQFSTATSLSNLSIVD------------------DEKAPASVAE 1103
                     |.:..|.||.....||.|:|||.|.:.:                  |.....|..|
Zfish  1352 ERFNLPQDLDTMIYFTVEKPIENFSCASSLSALPLHEHYVQKDVELKLTPLLNQQDNDPEESEKE 1416

  Fly  1104 EDNEDEL----------LLANCINMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDTPALLSK 1158
            ||.||:.          :|..|||..|..: .:.|:|||:.|   ::.:.|.....:..|..:
Zfish  1417 EDMEDQYSEGNSDDDIEILKECINSAMPSR-FKKVRSTVIPS---LSNQVINMQARKSVPVYM-- 1475

  Fly  1159 VPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGMKKPLGE 1223
            |..|.|..:          .|..:..|.:.::..|.||
Zfish  1476 VLQNKNNQM----------CTGQKLGMSSKEIYHDDSS--------------------------- 1503

  Fly  1224 ATSDPIAMLRRGGNELPGYLPSADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLVGPAVQLKETEP 1288
                              |..||        |.:|.|||..:.||
Zfish  1504 ------------------YTDSA--------EGTPINFSSTTSLS-------------------- 1522

  Fly  1289 SSADQNPEMKAKPGKQEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCNRP-----KSNLG 1348
               |:..:..|:....:..||....|:  |..:.....:|..:.|:     .::|     :|:|.
Zfish  1523 ---DETLQYPARTKGMKDWRRNKETQE--LVDIEAKRIEDLRMFSR-----FHKPTKIACQSHLV 1577

  Fly  1349 FSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQSKSLFELCIL 1413
            .:...|....:..:|.:.|.:...|:.    ||.::.|.|.....:.....|.::|....:..:.
Zfish  1578 TNQLNKTIRRMVPTQRLLIQSKEMAAK----MTQQRIQSQSPVRQIQKQGQNLSRSMPQLDFPMR 1638

  Fly  1414 KGMYKTKEPGARAQQMQEQPIVGSSSVQSNP-SLKQFDSLPVQLPSS--GQVKRQRHHHHHHHHR 1475
            |         ...:..|.|.....|.||.|. |||.     .:.|||  |...:...|....:..
Zfish  1639 K---------QSTEVYQNQKTCYLSHVQENTLSLKS-----RRHPSSTEGICHKMERHDGQMNRT 1689

  Fly  1476 ERERERKDEKLLQECINTGISKKINA----------VPKNVLATSAAALEPCHPMAATTSASALS 1530
            .|:::.....:::   |..|..::|:          :.:|::...|   .||:.:  ::|.|:||
Zfish  1690 GRKQQYDSSNIIR---NANIQDQVNSYQSRQNGFHRIKQNLILEEA---PPCYSL--SSSLSSLS 1746

  Fly  1531 TAAPDVEQKAHATSNPQQQSSTHPSSHI-LPNPIDAIATVTDTVRSPAAPNQGNGNASQNGLETA 1594
                |.|.:.|  .|||         |. :.|..:.::.:....:|....||...|:|.:
Zfish  1747 ----DAEFEEH--ENPQ---------HTWIKNRHNIMSNLQCHPKSQKDLNQFEENSSPS----- 1791

  Fly  1595 TGSKDLDSEDRSSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKSVERLTMEFVTSA 1659
              |..:||||            :.:::        ||:.|..:||.
Zfish  1792 --SVSMDSED------------DLLIK--------CITSAMPQHKK------------------- 1815

  Fly  1660 EQLRSSSHNHSSSNSHKNNSS-NNTWNESTCPNDVSFPSVSQTAPVLASLSLDEDATEARSLHE- 1722
               |.::....:...||..:: .....:....||:....::      :....|.::.|.|::.|
Zfish  1816 ---RQAARKRKAEKKHKQKATLQKAAEDRGLDNDLDSDEMA------SDKDSDLNSVEWRAIQEG 1871

  Fly  1723 ----LIEITPTNEQQPESLEGETDTLVNGHADSYSGSS----------------GGLNFQLGGQV 1767
                :.::..:..|:|.|   |::::::    ..||||                ..|:|.....|
Zfish  1872 ANTIITKLQASKSQEPSS---ESESVLS----FMSGSSFTPKEKKVYKDDKKANKPLDFAPRKPV 1929

  Fly  1768 QNAGVRLEPQRLLFN----------------GTSASIMTNSTMIAFEARALAENLLQPAATDDDT 1816
            .|..|....:.:::.                ...|....|..:....:|:| ..|.||.    ::
Zfish  1930 PNFPVVFRGRTVIYTPKKETTLSQRPPPKKVSPKADAPKNPNLAQHRSRSL-HRLGQPM----ES 1989

  Fly  1817 TEMTFSLNSLDLDNIRPPSGMESLNSCYQDHSQPSSLRQAMPSKSPR 1863
            |::     ||...:..||:.:..       .|...|.:.:.||:.|:
Zfish  1990 TQL-----SLPKRSSTPPARIPK-------SSSSGSSQSSTPSRQPQ 2024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	47/102 (46%)
		armadillo repeat	258..332	CDD:293788	34/92 (37%)
		ARM	332..448	CDD:237987	57/116 (49%)
		armadillo repeat	369..403	CDD:293788	15/34 (44%)
		armadillo repeat	411..448	CDD:293788	19/36 (53%)
		armadillo repeat	498..539	CDD:293788	23/40 (58%)
		ARM	506..624	CDD:237987	77/117 (66%)
		armadillo repeat	548..582	CDD:293788	25/33 (76%)
		armadillo repeat	590..624	CDD:293788	21/33 (64%)
		APC_crr	837..860	CDD:283553	2/22 (9%)
		APC_crr	903..927	CDD:283553	13/23 (57%)
		APC_crr	1066..1090	CDD:283553	10/23 (43%)
		APC_crr	1247..1271	CDD:283553	7/23 (30%)
apc2	XP_021335660.1	APC_N_CC	7..58	CDD:293294
		Suppressor_APC	156..233	CDD:314370	6/13 (46%)
		armadillo repeat	459..502	CDD:293788	22/44 (50%)
		armadillo repeat	510..547	CDD:293788	19/36 (53%)
		armadillo repeat	556..589	CDD:293788	14/32 (44%)
		armadillo repeat	597..638	CDD:293788	23/40 (58%)
		Arm	644..683	CDD:278915	28/38 (74%)
		armadillo repeat	647..681	CDD:293788	25/33 (76%)
		Arm	685..723	CDD:278915	23/37 (62%)
		armadillo repeat	689..723	CDD:293788	21/33 (64%)
		Arm_APC_u3	726..981	CDD:318770	56/264 (21%)
		APC_r	1132..>1150	CDD:310482	9/17 (53%)
		SAMP	1427..1448	CDD:310483	5/21 (24%)
		APC_r	1501..1523	CDD:310482	12/97 (12%)
		APC_basic	1934..>2106	CDD:310501	18/108 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580923
Domainoid	1	1.000	198	1.000	Domainoid score	I3030
eggNOG	1	0.900	-	-		E1_KOG2122
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1233
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002986
OrthoInspector	1	1.000	-	-		mtm6551
orthoMCL	1	0.900	-	-		OOG6_105450
Panther	1	1.100	-	-	LDO	PTHR12607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2812
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.750