Protein Alignment Apc and apc2

DIOPT Version :10

• Sequence 1: NP_477152.1
• Gene: Apc / 44642
• FlyBaseID: FBgn0015589
• Length: 2417
• Species: Drosophila melanogaster
• Sequence 2: XP_021335660.3
• Gene: apc2 / 565771
• ZFINID: ZDB-GENE-090422-1
• Length: 2489
• Species: Danio rerio
• Alignment Length: 2660
• Identity: 639/2660 - (24%)
• Similarity: 1012/2660 - (38%)
• Gaps: 783/2660 - (29%)

  Fly   127 AQELREMREHR--SLDRNFERQSAQQQQLDELPPRNGGGSPASAGRPSRSKEPSYTLSRFLDGDA 189
            ||:||.:.|.|  :.|...:|...:..:|::| .:....:.:|.|...:|..|....:..|   .
Zfish   219 AQQLRSVMEERFGTSDEMVQRTQIRVARLEQL-EKELHDAQSSRGPQEKSALPETQSTECL---P 279

  Fly   190 PAPAPRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQS 254
            .|..|.:..|.|.|..         .....|||||.|:.|||||.|.|..||::..|.:|.:.:|
Zfish   280 KACVPDMDTGNAGTLD---------APGEAGSKVEMVFWLLSMLASRDREEMSRTLLAMSSSQES 335

  Fly   255 CATLRRSGCMPLLVQMMHAPDN---------DQEVRKCAGQALHNVVHSHPDEKAGRREAKVLRL 310
            |..:|:|||:|||||::|....         .:|.|..|..||||:|:|.|||...|||.:||.:
Zfish   336 CIAMRKSGCVPLLVQILHEGGTGEAAGTGCYSREARSRASAALHNIVYSQPDEGQARREMRVLHV 400

  Fly   311 LDQIVDYC--------SFLKTLLQSGGEA--IADDSDRHPLAAISSLMKVSFDEEHRHAMCELGA 365
            |:||..:|        :.|.|....|.:.  |.:..|.....|:.::||:||:||:|.||.|||.
Zfish   401 LEQIRSHCENGWDWIENHLSTPSPGGSKTTEIPEPVDPQICQALCAIMKLSFEEEYRRAMNELGG 465

  Fly   366 LHAIPNLVHLDHAVHGPKPEDQCCN-SLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLD 429
            |.||..|:.||..::|...|.  .| :|||||.||:||||:||..|||.||.:|..::|:||||.
Zfish   466 LQAIAELMQLDQELYGMHNEP--INMALRRYAGMAVTNLTYGDVVNKATLCSKKNCLQAIVAQLA 528

  Fly   430 SAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHC 494
            |..::|.||.:|:|||||||||.|.|..|.::|:|:.|...|::...|:|||::||||||||||.
Zfish   529 SDSEELQQVVSSILRNLSWRADINSKRALRDVGSVSGLMTCALQATKESTLKSVLSALWNLSAHS 593

  Fly   495 STNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAI 559
            :.||...|:|||||.|||..|:|...:.:|.|||:.|||||||||.||..:.||||||.||||..
Zfish   594 TENKVAICSVDGALGFLVSTLTYRCQTNSLAIIESGGGILRNVSSLIATRDDYRQILRDHNCLQT 658

  Fly   560 LLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNL 624
            |||.|:|.|||:|||:|||||||||||.:||:.|||.|||.|||:||:|||.||:.||::||:||
Zfish   659 LLQHLRSHSLTIVSNACGTLWNLSARSPKDQELLWDLGAVSMLRNLINSKHKMIAMGSAAALRNL 723

  Fly   625 LNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLDTGG--------- 680
            |..||....    |....|.| ..:|:|..||.|||:.||..:|.|||.|.|:...
Zfish   724 LTNRPLKYK----DAAVISPG-SCMPSLYMRKQKALEAELDAKHLAETFDTLEKQSFKHANINKP 783

  Fly   681 -----KLDKERASSSS--RRHPAPRLTRS------AMLT----------------KSESRDSVYS 716
                 .|.|:.||.|.  ....||.::.|      :||:                :.|....:.:
Zfish   784 LRHIESLAKDYASDSGCFDDDEAPNVSTSLDTGTFSMLSMFLNNSNFLNTQLRKREGEPEQDIET 848

  Fly   717 AKSDCAYDHLIRSASASD----AHRKVKPKITDF---------DLEMEQDTE-----ATEEQPID 763
            .::|     :.||....|    |..|:..|||:.         |:.|...:|     ::|:..:|
Zfish   849 FQTD-----IKRSQPPDDEVTVAAEKLAKKITNTVAKIDKLVDDITMHTSSEDSFSLSSEDHFLD 908

  Fly   764 YSVKYSE-NATKTSTYQETDLDQPTDFS-------------LRYAENQIESDLDISGP-----AG 809
            ::....| :..:..:.....|...:.||             |:...:.:.:|...||.     .|
Zfish   909 WNYGPDELHEARAISCSPCPLSDSSTFSPKERLSRAHAFMRLKTTNSSLSNDSLNSGSISDGYCG 973

  Fly   810 GQKST--ITPPAE------------------------------TVPEKS-EGQEILLILDDSVKC 841
            .|..|  ...|.|                              .:||:. |..:..::.|.....
Zfish   974 SQDQTHPSARPTEQRRPNKLDLKVAHEEPLTNGVHISRVMCQNEIPERDFEANKDAILPDSGSTD 1038

  Fly   842 YQTEDTPYVISNAASVTDLRVAAKADAEAEVKPEVR-----------EVTSKEGAPKK------- 888
            .:....|::.:.|.      |:.|..:|..: |.|:           :..:|.|..|.
Zfish  1039 TEKSQEPFISTPAT------VSTKVSSETSI-PTVKLSPSYQHVPLIQSVAKFGVAKTAINVQAA 1096

  Fly   889 --------LPKLSQCGS-GSYTP------------EKPINYCEEGTPGYFSRYDSLSSLD----- 927
                    :|.:...|| ..::|            |.|..|..|.||..|||..|||||.
Zfish  1097 QAMRRQAWVPAVMTGGSISKFSPICSARSPTIGQLETPQKYSVENTPICFSRCSSLSSLSSGDGA 1161

  Fly   928 -----------ESGKANQAIVGTDADIKPKLEKQEEQ------------------ESQPAE---- 959
                       ||..:.:.|...|.:::.|.|:.|.:                  .|.|.|
Zfish  1162 LDGQSQTENELESDSSLEIIEVEDVNVERKDEEDENETLDDLSDSQLLVTDQKISSSDPIEISGT 1226

  Fly   960 ------------QVLTKPPTQANSA----LETPLMFSRRSSMDSLVHDPDVDVANCDDKSSVVSD 1008
                        .|:.:..|.::|:    .||||:.||.||:.||.......:|     ||:.||
Zfish  1227 IKNEKRFLRGVSPVILEDRTPSSSSDNYIHETPLVMSRCSSVSSLGSFESPSIA-----SSIQSD 1286

  Fly  1009 -FSRLASGVISPSEIPDSPTQSMPQSPRR-----NSVAGSGQNVDSPPVVIPASLQPLRSVFE-- 1065
             .|.:.||.:|||::||||.|:||.|..:     .|.....||:........:||:....:.:
Zfish  1287 PCSEMISGTVSPSDLPDSPGQTMPPSRSKTPCCPESGGADAQNLSGVGSQWESSLRKFMEIADFK 1351

  Fly  1066 ---------DDLSSFNVEHTPAQFSTATSLSNLSIVD------------------DEKAPASVAE 1103
                     |.:..|.||.....||.|:|||.|.:.:                  |.....|..|
Zfish  1352 ERFNLPQDLDTMIYFTVEKPIENFSCASSLSALPLHEHYVQKDVELKLTPLLNQQDNDPEESEKE 1416

  Fly  1104 EDNEDEL----------LLANCINMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDTPALLSK 1158
            ||.||:.          :|..|||..|..: .:.|:|||:.|   ::.:.|.....:..|..:
Zfish  1417 EDMEDQYSEGNSDDDIEILKECINSAMPSR-FKKVRSTVIPS---LSNQVINMQARKSVPVYM-- 1475

  Fly  1159 VPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGMKKPLGE 1223
            |..|.|..:          .|..:..|.:.::..|.||
Zfish  1476 VLQNKNNQM----------CTGQKLGMSSKEIYHDDSS--------------------------- 1503

  Fly  1224 ATSDPIAMLRRGGNELPGYLPSADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLVGPAVQLKETEP 1288
                              |..||        |.:|.|||..:.||
Zfish  1504 ------------------YTDSA--------EGTPINFSSTTSLS-------------------- 1522

  Fly  1289 SSADQNPEMKAKPGKQEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCNRP-----KSNLG 1348
               |:..:..|:....:..||....|:  |..:.....:|..:.|:     .::|     :|:|.
Zfish  1523 ---DETLQYPARTKGMKDWRRNKETQE--LVDIEAKRIEDLRMFSR-----FHKPTKIACQSHLV 1577

  Fly  1349 FSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQSKSLFELCIL 1413
            .:...|....:..:|.:.|.:...|:.    ||.::.|.|.....:.....|.::|....:..:.
Zfish  1578 TNQLNKTIRRMVPTQRLLIQSKEMAAK----MTQQRIQSQSPVRQIQKQGQNLSRSMPQLDFPMR 1638

  Fly  1414 KGMYKTKEPGARAQQMQEQPIVGSSSVQSNP-SLKQFDSLPVQLPSS--GQVKRQRHHHHHHHHR 1475
            |         ...:..|.|.....|.||.|. |||.     .:.|||  |...:...|....:..
Zfish  1639 K---------QSTEVYQNQKTCYLSHVQENTLSLKS-----RRHPSSTEGICHKMERHDGQMNRT 1689

  Fly  1476 ERERERKDEKLLQECINTGISKKINA----------VPKNVLATSAAALEPCHPMAATTSASALS 1530
            .|:::.....:::   |..|..::|:          :.:|::...|   .||:.:  ::|.|:||
Zfish  1690 GRKQQYDSSNIIR---NANIQDQVNSYQSRQNGFHRIKQNLILEEA---PPCYSL--SSSLSSLS 1746

  Fly  1531 TAAPDVEQKAHATSNPQQQSSTHPSSHI-LPNPIDAIATVTDTVRSPAAPNQGNGNASQNGLETA 1594
                |.|.:.|  .|||         |. :.|..:.::.:....:|....||...|:|.:
Zfish  1747 ----DAEFEEH--ENPQ---------HTWIKNRHNIMSNLQCHPKSQKDLNQFEENSSPS----- 1791

  Fly  1595 TGSKDLDSEDRSSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKSVERLTMEFVTSA 1659
              |..:||||            :.:::        ||:.|..:||.
Zfish  1792 --SVSMDSED------------DLLIK--------CITSAMPQHKK------------------- 1815

  Fly  1660 EQLRSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSFPSVSQTAPVLASLSLDEDATEARSLHE-- 1722
               |.::....:...||..:       :...||:....::      :....|.::.|.|::.|
Zfish  1816 ---RQAARKRKAEKKHKQKA-------TLLDNDLDSDEMA------SDKDSDLNSVEWRAIQEGA 1864

  Fly  1723 ---LIEITPTNEQQPESLEGETDTLVNGHADSYSGSS---GGLNFQLGGQVQNAGVRLEPQRLLF 1781
               :.::..:..|:|.|   |::::::    ..||||   .........:..|..:...|::.:.
Zfish  1865 NTIITKLQASKSQEPSS---ESESVLS----FMSGSSFTPKEKKVYKDDKKANKPLDFAPRKPVP 1922

  Fly  1782 NGTSASIMTNSTMIAFEARALAENLLQPAATDDDTTEMTFSLNSLDLDNIRPPSGMESLNSCYQD 1846
            |          ..:.|..|.:   :..|      ..|.|.|.        |||
Zfish  1923 N----------FPVVFRGRTV---IYTP------KKETTLSQ--------RPP------------ 1948

  Fly  1847 HSQPSSLR-QAMPSKSPRFARKMFPANLVARRALGHLAGSAESVNSSCNLLDNIKPPSLMDELLD 1910
               |..:. :|...|:|..|:.       ..|:|..|....||...|.....: .||:.:.:...
Zfish  1949 ---PKKVSPKADAPKNPNLAQH-------RSRSLHRLGQPMESTQLSLPKRSS-TPPARIPKSSS 2002

  Fly  1911 SMISVDSIQSEVADGEQDCSMATTISVSNYETAACDDQTMTVLQSCFDEDEDATMNDYSSAESTP 1975
            |    .|.||.....:....:.:...:...|..|                         ||.|:|
Zfish  2003 S----GSSQSSTPSRQPQKKVTSQPPIKGTEKVA-------------------------SAPSSP 2038

  Fly  1976 --KHGSTPSPNRRSLTPKDKRRLTKDRFKTYTIATSCEMEAPEANETLQIEIVEAAVPVATPSPR 2038
              :.|...:.::.|.:|.|:        ||.............:.:|..|.      |:.|..|.
Zfish  2039 PDRRGRNSNIDQNSKSPIDR--------KTQKSPVRIPFMQNPSRQTRNIS------PLVTNQPT 2089

  Fly  2039 ANGRRRGSAERYKTQLIECPLALIQPQPDDCPSEQLSSIR--------------AMMQQFTFITD 2089
                   |..|..||:....:         .|:.::..:|              ..::|.|||.:
Zfish  2090 -------SISRQNTQMSGKRI---------LPANRIDLVRMTSAHSSSGESDQNGFLRQLTFIKE 2138

  Fly  2090 IN----IGHSQETCESTDH--PEDAGE--------SPECDQNSETESCDGQEPDQLPPPPSIVDL 2140
            .:    ...|..:..::.|  |..:|.        |..|.:..|..    |.|.::|    :...
Zfish  2139 TSKVSRYDASSRSVPASQHASPRRSGPGAPAVFLCSSRCQELKEAV----QGPKRMP----VTHG 2195

  Fly  2141 RTSVVKPTTLEPATAVKLVRGRKKPAYVSPYSMQSQRNSNNAAPSKKKTLSPTIAKRSLVPGGSG 2205
            :..|.:...|....|:.......:...|:    :..|.:::.:|.:
Zfish  2196 QRQVQEQGVLRQGMALSRATSIDRDVTVN----RPARRTSSESPCR------------------- 2237

  Fly  2206 VRLPAKKKPTPPPEPAPARLERQGTFVKDEPTNS-NVQVPVVETKPAQTSPTHRASKLPTKKGTA 2269
                |.|:.||.|:|   |.:|..||.:...:.| ||...|......::|.:..:.:..:::..
Zfish  2238 ----ASKRNTPCPKP---REKRDDTFKRYSSSPSINVLSRVTSRSSLRSSSSDSSGRAKSERNV- 2294

  Fly  2270 SGGSPSKAG-------------------------SPKRIPLAPA---RRMTPQRAN--TSLRLAA 2304
             .....:||                         .|..:||.|:   ::|.|....  .::.||:
Zfish  2295 -NQKQQRAGLRNADKVTWRRIRDEDVPQILKSTLPPTALPLLPSPGTKQMPPPLPGKLPTITLAS 2358

  Fly  2305 GKS---------HAASRVVSGRVSSTTPPSRSNSNLNGSSAAAAAAAKI----NHAQSRIAN-IW 2355
            .|:         ::|::.    .|||:|......::...:|..|...||    |..|...:: ..
Zfish  2359 RKTSDATVQTEDYSANKT----NSSTSPTIDKGLSITEETAKIALPKKIVVFGNTLQDGDSDGSL 2419

  Fly  2356 KRVDEAKTKQSSSNLRTQKTKSSNMLNANGTKPT-LLRSSTFDNTPSTAGGVKSKLPVVG 2414
            |....|.|....|   |:.|.||.:.:...:.|: .:|.:.|:..||         |:||
Zfish  2420 KNYSTASTATFQS---TESTHSSGVGHFRQSSPSKAVRVTPFNYIPS---------PMVG 2467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_477152.1	ARM	251..293	CDD:214547	19/50 (38%)
		armadillo repeat	258..332	CDD:293788	34/92 (37%)
		APC_rep	294..360	CDD:465870	26/75 (35%)
		armadillo repeat	369..403	CDD:293788	15/34 (44%)
		armadillo repeat	411..448	CDD:293788	19/36 (53%)
		armadillo repeat	498..539	CDD:293788	23/40 (58%)
		Arm	544..584	CDD:425727	28/39 (72%)
		armadillo repeat	548..582	CDD:293788	25/33 (76%)
		armadillo repeat	590..624	CDD:293788	21/33 (64%)
		APC_15aa	757..771	CDD:461790	3/14 (21%)
		APC_r	903..926	CDD:461781	12/22 (55%)
		APC_r	1066..1089	CDD:461781	10/22 (45%)
		APC_r	1247..1270	CDD:461781	7/22 (32%)
		Herpes_BLLF1	<2239..>2413	CDD:282904	41/219 (19%)
apc2	XP_021335660.3	None