DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and arvcfb

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	XP_009299795.1	Gene:	arvcfb / 564669	ZFINID:	ZDB-GENE-060526-60	Length:	1048	Species:	Danio rerio

Alignment Length:	1066	Identity:	205/1066 - (19%)
Similarity:	343/1066 - (32%)	Gaps:	380/1066 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLTPDLEEGIAEL--SLEDVDVDSVPERKPHFLDYDAVPPPDYEEGFGASSGEQLKMDKKYERDG 67
            |.||...:.:.::  ::....|..||      |..|.:|.|:.....|:.:.   .:|::|.::|
Zfish   162 TPTPSETKPVTKMVKTVTTRTVRQVP------LGPDGLPVPEGSSPLGSYTD---SIDRRYMKNG 217

  Fly    68 E-----------VSDYELAASGYTKKEFTQ-------------DDN------------------- 89
            |           ...|...:..|.....||             .||
Zfish   218 ERFITPQATSTLTRSYNNYSDSYNDTPDTQFRHYTLHDGYGDMPDNYGSLSRGVNYRPYRPYMPT 282

  Fly    90 ---------TL--------HFTQSAVGLGSGAVG-KKPAAKHFL----------------DENP- 119
                     ||        |..|..|.:||..|. .:...:.|.                ||.|
Zfish   283 GGYRPENSYTLPIRKDDYGHVAQPQVPMGSSTVDLNRSQPERFQPEPYGLEDDRRSLGPEDEEPY 347

  Fly   120 -IPPDYMLA-------QELREMREHRSLDRNFERQSAQQQQLDELPPRNGGGSPASAGRPSRSKE 176
             :.|||..|       :.:||...:....|.:| ...:.:.:||..|...|..||...:|.|...
Zfish   348 DLEPDYSTANRRTLPGRTIREPLRNGPRVRGYE-DPIEAELIDERHPYIHGMYPAPLAQPERGSM 411

  Fly   177 PSYTLSRFLDGDAPAPA------------PRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYS- 228
            .|  |.|.  |...:|:            |.||:                |.|.||..::.|.|
Zfish   412 AS--LDRM--GGRRSPSIDSIRKDPRWRDPDLPE----------------VIAMLGHPIDPVKSN 456

  Fly   229 ----LLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPDNDQEVRKCAGQALH 289
                |..:...||.::  |...:|.|             :|:||.::..|  ..||.:.|..||.
Zfish   457 AAAYLQHLCYENDKIK--KDVRQLKG-------------IPVLVSLLDHP--KAEVHRKACGALR 504

  Fly   290 NVVH--SHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDSDRHPLAAIS-SLMKVS 351
            |:.:  .|.::.|              :..|..:..|::    .:...:|......|: :|..:|
Zfish   505 NISYGKDHDNKVA--------------IKSCDGIPALIR----LLRKTNDMEVRELITGTLWNLS 551

  Fly   352 FDEEHRHAMCELGALHAIPNLVHLDHA--VHGP----KPEDQCCNSLRRYALMALTNLTFGDENN 410
            ..|..:..:...| |..:.|.|.:.|:  .|.|    ||.|....::.:.....|.|::......
Zfish   552 SYEPLKMVIINHG-LQTMTNEVIIPHSGWEHEPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEA 615

  Fly   411 KALLCGQKQFMEALVAQLDSA------PDDLLQVTASVLRNLSWRADSNMKAV--LNEIGTVTAL 467
            :..|...:..::||:..|.||      .:..::....::||||:.....:...  ..:...:.|.
Zfish   616 RRRLRECEGLVDALLHALQSAVGKKDMDNKSVENCVCIMRNLSYHVHKEVPGAEKFQDPSALQAP 680

  Fly   468 ALAAMRNRSENTL------KAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEG------- 519
            ..|..:.:.::..      ||  ...|...||      :.|           :..|||
Zfish   681 GSAGTQRKKKDDAGCFGGKKA--KEEWFNQAH------QVC-----------LEQYEGRKNGEHD 726

  Fly   520 --------PSKTLKIIENAGGILRNVSSHIAVCEPYR--QILRQHNCLAILLQQL-KSESLTVVS 573
                    |.:|                     ||.:  ::|.|...:.:.|..| :|::...:.
Zfish   727 KNYDTLDLPKRT---------------------EPTKGFELLYQPEVVRLYLSLLTESQNYNTLE 770

  Fly   574 NSCGTLWNLSARSAEDQKFLWDN---------GAVPMLRSLIHSKHAMISEGSSSALKNLLNFRP 629
            .:.|.|.||||     .::.|.|         ..:|:|..|:.|....:....:.||:||...|
Zfish   771 AAAGALQNLSA-----GQWTWSNYIRATVRKEKGLPILVELLRSDSDKVVRAVAIALRNLSIDR- 829

  Fly   630 AVQNHHQLDPIARSMGLKALPTLEARKAKALQQE-----LGERH-----TAETCDNLDTGGKLDK 684
              :|...:...|....:..||:.:.|.||.|:::     |...|     ::|...:|.|...:||
Zfish   830 --RNKDLIGSYAMRDLVSNLPSGQQRPAKNLEEDTVVAILNTIHEIITDSSENARSLITAQAIDK 892

  Fly   685 ERASSSSRRHPAPRLTRSAMLTKSESR--DSVYSAKSDCAYDHLIRSASASDAHRKV-------- 739
            ..|.:        |.::||..||:.|.  .:|:|.|.       :|:|...|...|.
Zfish   893 LVAIN--------RTSQSARETKAASHVLQTVWSYKE-------LRNALTKDGWNKTHFQPIAAG 942

  Fly   740 --------KPKITDFDLEMEQDTEA------------TEEQPIDYSVKYSENATKTSTYQETDLD 784
                    ||...|..|.:.:.::.            .|..|..|           ||..:.|.|
Zfish   943 TPKGSKSCKPGYDDTTLPLMEKSQGHRGCSGGDMIPMDELGPDGY-----------STIDQRDKD 996

  Fly   785 QPTDFSLRYAENQIESDLDISGPAGGQKSTITPPAETVPEKSEGQEILLILDDSVKCYQTEDTPY 849
            .      :|..:.|.|||.                |..|.|::                |....|
Zfish   997 S------KYKSSDISSDLQ----------------EREPLKND----------------TNRKHY 1023

  Fly   850 VISNAASVTDLRVAAKADAEAEVKPE 875
            :.||..:|      :..|| .:|||:
Zfish  1024 IRSNRPTV------SLVDA-CDVKPQ 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	20/100 (20%)
		armadillo repeat	258..332	CDD:293788	14/75 (19%)
		ARM	332..448	CDD:237987	26/128 (20%)
		armadillo repeat	369..403	CDD:293788	9/39 (23%)
		armadillo repeat	411..448	CDD:293788	9/42 (21%)
		armadillo repeat	498..539	CDD:293788	6/55 (11%)
		ARM	506..624	CDD:237987	26/144 (18%)
		armadillo repeat	548..582	CDD:293788	7/36 (19%)
		armadillo repeat	590..624	CDD:293788	8/42 (19%)
		APC_crr	837..860	CDD:283553	5/22 (23%)
		APC_crr	903..927	CDD:283553
		APC_crr	1066..1090	CDD:283553
		APC_crr	1247..1271	CDD:283553
arvcfb	XP_009299795.1	ARM	434..552	CDD:237987	32/168 (19%)
		armadillo repeat	439..464	CDD:293788	9/40 (23%)
		armadillo repeat	472..508	CDD:293788	13/52 (25%)
		armadillo repeat	515..550	CDD:293788	6/52 (12%)
		armadillo repeat	557..608	CDD:293788	11/51 (22%)
		ARM	745..849	CDD:237987	25/111 (23%)
		armadillo repeat	745..781	CDD:293788	9/35 (26%)
		HEAT_2	757..>825	CDD:290374	17/72 (24%)
		armadillo repeat	791..825	CDD:293788	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910