DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and ctnnd2b

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	NP_001352544.1	Gene:	ctnnd2b / 558069	ZFINID:	ZDB-GENE-070912-532	Length:	1229	Species:	Danio rerio

Alignment Length:	1229	Identity:	240/1229 - (19%)
Similarity:	384/1229 - (31%)	Gaps:	418/1229 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PPPDYEEGFGASSGEQLKMDKKYERDGEVSDYELAASGYTKKEFTQDDNTLHFTQSAVGLGSGAV 105
            ||...:.|....|..|:..:    |..:::..|.||..:::..:.|...
Zfish   172 PPRSGQVGGALHSYNQVTSN----RVAQLAARETAARAHSRDSYAQSHG---------------- 216

  Fly   106 GKKPAAKHFLDENP-IPPDYMLAQELREMREHRSLDRNFERQSAQQQQLDELPPRNGGGSPASAG 169
                :|.|..|:.| :|.:|..| .|...|    :...|..|:.              |||:...
Zfish   217 ----SAFHMPDDQPTVPVNYSCA-TLPAQR----VSSPFSMQAL--------------GSPSKLQ 258

  Fly   170 R-PSRSKEPSY-TLSRFLDGDAPAPAP-RLPKGAAWTTSFDERYTSSAVEATLG----------- 220
            | .|.|..||| ||:|.   .:|..:| ||.|..:         |||.:....|
Zfish   259 RLGSASDMPSYATLARV---SSPKQSPSRLAKSYS---------TSSPINMAAGGGSSSSPLHMA 311

  Fly   221 -----SKVECVYSLLSMLGSNDPLEMAKKFL------ELSGNAQSCATLRRSGCM-----PLLVQ 269
                 |....::.|.:.:||...|...|:.|      ::|.:..:.|||:|.|.:     ....|
Zfish   312 GAGNVSNSSPLHQLSAAVGSYATLSPTKRMLHTTDQYKISHDLYANATLQRPGSLAGSRGSYSSQ 376

  Fly   270 MMHAPDNDQEVRKCAGQALH-------NVVHSHPDEKAGRREAKVLRLLDQIVDY--CSFLKTLL 325
            ..|.   ..|:|.......|       .|....|.....:.:..:.:..||::::  |.:...:.
Zfish   377 HSHL---GSELRPLQSPEHHIDPIYEDRVYQKAPLRNFNQAQDPMNQFCDQVLNFLLCPYSPVIA 438

  Fly   326 QSG-----------------------------GEAIAD--------------DSD---------- 337
            .|.                             |.:.||              ||.
Zfish   439 PSSPGVDSIPLQRTGSQNATGTFPRAGYATGPGASTADYANPYRTLQFCPSTDSPYSKSGPALPP 503

  Fly   338 -----RHPLAAISSLMK-VSFDEE---------HRHAMCELGALH-AIPNLVH-LDHAVHGPKPE 385
                 |.|  ::.|:.| ..:|.|         .:....|.|... .:|.::. |.|..
Zfish   504 EATLVRSP--SVDSIQKDPRYDPEFLVWNQNQAEQRMTKEFGWRDPELPEVIQMLQHQF------ 560

  Fly   386 DQCCNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLDSAPDDLLQVTASVLRNLSW-R 449
                .|::..|...|.:|.|||...|:.:..|.. ::.||..||....|:.:.....||||.: :
Zfish   561 ----PSVQSNAAAYLQHLCFGDNKIKSEIRRQGG-IQLLVDLLDHRMTDVHRSACGALRNLVYGK 620

  Fly   450 ADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILS-ALWNLSAHCSTNKAEFCAVDGALAFLVG 513
            |:.:.|..|...|.:.|| :..:|..::..::.:|: .|||||: |...|...  :..|||.|..
Zfish   621 ANDDNKIALKNCGGIPAL-VRLLRKTTDVEIRELLTGVLWNLSS-CDALKMPI--IQDALAVLTN 681

  Fly   514 --MLSYEG----PSK--------TLKIIENAGGILRNVSS-------HIAVCEPYRQILRQ---- 553
              ::.:.|    |.:        :.:::.||.|.||||||       .:..||.....|..
Zfish   682 TVIIPHSGWDTSPLQDDRKLHLHSSQVLRNATGCLRNVSSAGEEARRRMRECEGLTDALLYVIQT 746

  Fly   554 ------------HNCLAILL-------------QQLKSESLTVV-----------SNSCGTLW-- 580
                        .||:.||.             ||:.||.|..|           |:.|   |
Zfish   747 ALGTSEIDSKTIENCVCILRNLSYRLAAETSQGQQMGSEELDGVLCTDASGKDAESSGC---WGK 808

  Fly   581 NLSARSAEDQ-----------------KFLWDNGAV-PMLRSLIHSKHAMISEGSSSALKNLLNF 627
            ....:.:.||                 :.||....| |.|..|....:....||::.||:||
Zfish   809 KKKKKKSHDQWDGVGPFPDSSDPPKGLQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNL--- 870

  Fly   628 RPAVQNHHQLDPIARSMGLKALPTLEARKA---KALQQELGERHTAETCDNLDTGGKLDKER--- 686
                          .:...|..|||:....   .|:::|.|.....|..       ::|.:|
Zfish   871 --------------AAGSWKVGPTLKPWSVYIRAAVRKEKGLPILVELL-------RIDNDRVVC 914

  Fly   687 ASSSSRRHPAPRLTRSAMLTKSESRDSVY---------------SAKS---------DCAYDHLI 727
            |.:::.|:.|..:....::.|...||.|:               |:||         .||...:|
Zfish   915 AVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNNNSTGTGGSSKSMSDDTITAICCALHEVI 979

  Fly   728 RSASASDAHRKVKPKITDFDLEMEQDTEATEEQPIDYSV--------KYSENATKTSTYQETDLD 784
            ..                   .||......:...|:..:        |::....|.::.....:.
Zfish   980 TK-------------------NMENTKALRDAGGIEKLIGIARSKGDKHTPKVVKAASQVLNSMW 1025

  Fly   785 QPTDFSLRYAENQIESDLDISGPAGGQKSTITPPAETVPEKSEGQEILLILDDSVKCYQTEDTPY 849
            |..|....|                               |.:|......:..|....:....||
Zfish  1026 QYRDLRSLY-------------------------------KKDGYSQYHFVGSSSTIERDRQRPY 1059

  Fly   850 VISNAASVTDLRVAA-KADAEAEVKPEVREVTSKEGAPKKLPKLSQCGSGSYTPEKPINYCEEGT 913
            ..|...|::.:|.:. ...|.|...|  ||:.|     .|..|.....:||       |....|.
Zfish  1060 SSSRTPSISPVRTSPNNRSASAPTSP--REMMS-----LKERKTDYESTGS-------NSTYHGN 1110

  Fly   914 PG-YFSRYDSLSSLDESGKA---NQAIVGTDADIKPKLEKQEEQESQPAEQVLTKPP--TQANSA 972
            .| :.||.|::::...||.:   ..|.:....|||   ..|...:..|.|   ..||  |...:.
Zfish  1111 KGEHTSRKDAMAAQISSGTSTLFRGAYMSPADDIK---HNQVSAQGNPPE---AYPPFQTPPGAN 1169

  Fly   973 LETPLMFSRR-----SSMDSLVHDPDVDVANCDDKSSVVSDFSRLASGVISPSEIPDSP 1026
            .|.|....:.     .:.|..:|.......|..|..|....:|.|.   ...|..|.||
Zfish  1170 FEEPYYEDQAHKRPPPAADGTMHLGLKSTGNYVDFYSASRPYSELN---YETSHYPASP 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	21/111 (19%)
		armadillo repeat	258..332	CDD:293788	15/116 (13%)
		ARM	332..448	CDD:237987	33/156 (21%)
		armadillo repeat	369..403	CDD:293788	6/34 (18%)
		armadillo repeat	411..448	CDD:293788	11/36 (31%)
		armadillo repeat	498..539	CDD:293788	14/54 (26%)
		ARM	506..624	CDD:237987	43/198 (22%)
		armadillo repeat	548..582	CDD:293788	14/75 (19%)
		armadillo repeat	590..624	CDD:293788	11/51 (22%)
		APC_crr	837..860	CDD:283553	5/22 (23%)
		APC_crr	903..927	CDD:283553	6/24 (25%)
		APC_crr	1066..1090	CDD:283553
		APC_crr	1247..1271	CDD:283553
ctnnd2b	NP_001352544.1	PLN03200	547..>720	CDD:331927	48/187 (26%)
		armadillo repeat	549..574	CDD:293788	6/34 (18%)
		ARM	578..618	CDD:214547	12/40 (30%)
		armadillo repeat	582..618	CDD:293788	11/36 (31%)
		ARM	622..663	CDD:214547	11/41 (27%)
		armadillo repeat	626..661	CDD:293788	9/35 (26%)
		armadillo repeat	668..719	CDD:293788	12/52 (23%)
		Arm	831..872	CDD:278915	12/57 (21%)
		armadillo repeat	835..872	CDD:293788	12/53 (23%)
		ARM	889..924	CDD:214547	8/41 (20%)
		armadillo repeat	889..923	CDD:293788	8/40 (20%)
		armadillo repeat	930..980	CDD:293788	9/49 (18%)
		armadillo repeat	986..1021	CDD:293788	3/34 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910