DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and Apc2

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	NP_001334699.1	Gene:	Apc2 / 42871	FlyBaseID:	FBgn0026598	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	1247	Identity:	610/1247 - (48%)
Similarity:	757/1247 - (60%)	Gaps:	229/1247 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 LEMAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPDND-QEVRKCAGQALHNVVHSHPDEKAGR 302
            ||:.:.|||||.|.::|..||.|.|:.||||::||.|.. ...:|.|.|||||:||::|:||..:
  Fly    11 LELTRNFLELSRNPETCTALRSSDCIQLLVQILHANDEGLSTAKKYASQALHNIVHNNPEEKERQ 75

  Fly   303 REAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDSDRHPLAAISSLMKVSFDEEHRHAMCELGALH 367
            ||.|:|||||||:|||:||.|.|||||||||||.|||||||:..|||.|||||||..|||||||.
  Fly    76 REVKMLRLLDQILDYCNFLHTQLQSGGEAIADDEDRHPLAAMKLLMKASFDEEHRQTMCELGALK 140

  Fly   368 AIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDEN--NKALLCGQKQFMEALVAQLDS 430
            |||||||||||||||....:.||:||.|.|||||||||||||  ||:.||||:||||.::|||::
  Fly   141 AIPNLVHLDHAVHGPAAGREQCNALRSYGLMALTNLTFGDENVHNKSYLCGQRQFMEVVIAQLNT 205

  Fly   431 APDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHCS 495
            |||:||||.|.||||||||||.:||.:.||:||||:||.|||:|::|||||||||||||||||||
  Fly   206 APDELLQVLAGVLRNLSWRADKHMKTIFNELGTVTSLARAAMQNKNENTLKAILSALWNLSAHCS 270

  Fly   496 TNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAIL 560
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||::||||||
  Fly   271 TNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRRYNCLAIL 335

  Fly   561 LQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLL 625
            |||||||||||||||||||||||||..|||::|.|:.|:|:||:||.||::||:|||:||||||:
  Fly   336 LQQLKSESLTVVSNSCGTLWNLSARCPEDQQYLIDHNAIPLLRALISSKNSMIAEGSASALKNLV 400

  Fly   626 NFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLDTGGKLDKERAS-- 688
            ||| |.|   :|.|....   .:||         |.:|.|.            ||.|.:..:|
  Fly   401 NFR-ATQ---ELMPNGDG---GSLP---------LDKEAGH------------GGTLPRRFSSLR 437

  Fly   689 -------SSSRRHPAPRLTRSAMLTKSESRDSVYSAKSDCAYDHLIRSASASDAHRKVKPKITDF 746
                   |..:..|:...|...:..|.|||:|:||.||| :..:..:|..|.:....|.|
  Fly   438 LSSNPTGSLKKVRPSTVSTTGFLNRKCESRESIYSGKSD-STKYSTKSEGAKNPFEIVTP----- 496

  Fly   747 DLEMEQDTEATEEQPIDYSVKYSENATKTSTYQETDLDQPTDFSLRYAENQIESDLDISGPAGGQ 811
                      |||||||||:||.|:...:|...|.|||||||||.||.|.:
  Fly   497 ----------TEEQPIDYSMKYMEHKPNSSKTFEIDLDQPTDFSARYKERR-------------- 537

  Fly   812 KSTITPPAETV-PE-KSEGQEILLILDDSVKCYQTEDTPYVISNAASVTDLRVAAKADAEAEVKP 874
                  .|:|. || |||..||             ......::.::|.|:||.:....|.:..|.
  Fly   538 ------SAQTAQPELKSETNEI-------------RSKELQLTKSSSATELRNSPGLVAVSAAKQ 583

  Fly   875 EVREVTSKEGAPKKLPKLSQCGSGSYTPEKPINYCEEGTPGYFSRYDSLSSLDESGKANQAIVGT 939
            ::...|..|                 |.|:|||||||||||.|||:|||:||.|
  Fly   584 KIATETETE-----------------TAERPINYCEEGTPGSFSRFDSLNSLTE----------- 620

  Fly   940 DADIKPKLEKQEEQESQPAEQVLT-----KPPTQANSALETPLMFSRRSSMDSLVHDPDVDVANC 999
                ||  ||....::.....||.     ..|...:|||||||||||||||||||.| |..|| |
  Fly   621 ----KP--EKCMPPKTPTKTAVLPVHVDGNTPQNIDSALETPLMFSRRSSMDSLVGD-DETVA-C 677

  Fly  1000 DDKSSVVSDFSRLASGVISPSEIPDSPTQSMPQSPRRNSVAGSGQNVDSPPVVIPASLQPLRSVF 1064
            :|..||:|::||:.||||||||:||||||||||||||:....:..|:|:|.       |...:||
  Fly   678 EDNGSVISEYSRMQSGVISPSELPDSPTQSMPQSPRRDRKVSTQNNLDTPE-------QKPSTVF 735

  Fly  1065 EDDLSSFNVEHTPAQFSTATSLSNLSIVDDEKAPASVAEEDNEDELLLANCINMGMQRKPTEAVK 1129
            ||.|:.|:||||||.||.||||||||::||..|.|...:..|:
  Fly   736 EDKLNRFHVEHTPAAFSCATSLSNLSMMDDSNANAIRGQRGND---------------------- 778

  Fly  1130 STVVNSEVDVAEETIRSYCTEDTPALLSKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDV 1194
               :|...|..    ||||||||.|:|||.|||::||::|:    |.|..|.:||        .|
  Fly   779 ---INGNGDAP----RSYCTEDTTAVLSKAPSNSDLSILSI----PNDLNANEAQ--------PV 824

  Fly  1195 SSNASDCGGASGHLLQQCIRDGMKKPLGEATSDPIAMLRRGGNELPGYLPSADEMNKFLVEDSPC 1259
            .:..:|..|....:               ...|.|:.:|.|||.||.|||.:|||:|:.||||||
  Fly   825 PAPRADVTGMDTRM---------------PAEDAISKMRCGGNALPSYLPVSDEMSKYYVEDSPC 874

  Fly  1260 NFSVVSGLSNLTVGSSLVGPAVQL--KETEPSSADQNPEMKAKPGKQEQVRRPPHWQDDSLSSLS 1322
            .|||:||||:|||||:..||.::|  :..|.:.|.:.|..::......:.|.||. :.|||||||
  Fly   875 TFSVISGLSHLTVGSAKAGPVLKLPMRTAEEAQAPKLPPRRSAVQGDAEPRLPPK-KSDSLSSLS 938

  Fly  1323 IDSEDDTNLLSQAIAAGCNRPKSNLGFSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQ- 1386
            :||:||.||||||||||..||:     .|....||||:       ||:||.....:..:.::.:
  Fly   939 MDSDDDCNLLSQAIAAGSCRPQ-----PSGASTSSSLA-------NASTSTLCRENGQSKKQVEH 991

  Fly  1387 -QQESYSSVDSSDSNDN--QSKSLFELCILKGMYKTKE--------PGARAQQMQEQPIVGSSSV 1440
             .:.:|||.||.|.:|:  :||||||.|||.||:|:.:        ||      |.|.|......
  Fly   992 GDKPNYSSDDSLDDDDDDARSKSLFEQCILSGMHKSNDALESEGEPPG------QRQEISARDRF 1050

  Fly  1441 QSNPSLKQFDSL 1452
            .|| .::|.:|:
  Fly  1051 VSN-QVRQIESM 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	42/77 (55%)
		armadillo repeat	258..332	CDD:293788	45/74 (61%)
		ARM	332..448	CDD:237987	87/117 (74%)
		armadillo repeat	369..403	CDD:293788	24/33 (73%)
		armadillo repeat	411..448	CDD:293788	25/36 (69%)
		armadillo repeat	498..539	CDD:293788	40/40 (100%)
		ARM	506..624	CDD:237987	100/117 (85%)
		armadillo repeat	548..582	CDD:293788	31/33 (94%)
		armadillo repeat	590..624	CDD:293788	20/33 (61%)
		APC_crr	837..860	CDD:283553	2/22 (9%)
		APC_crr	903..927	CDD:283553	19/23 (83%)
		APC_crr	1066..1090	CDD:283553	17/23 (74%)
		APC_crr	1247..1271	CDD:283553	17/23 (74%)
Apc2	NP_001334699.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449432
Domainoid	1	1.000	198	1.000	Domainoid score	I3030
eggNOG	1	0.900	-	-		E1_KOG2122
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002986
OrthoInspector	1	1.000	-	-		mtm6551
orthoMCL	1	0.900	-	-		OOG6_105450
Panther	1	1.100	-	-	P	PTHR12607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.740