DRSC/TRiP Functional Genomics Resources

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Protein Alignment Apc and apc

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:NP_001137312.1 Gene:apc / 386762 ZFINID:ZDB-GENE-031112-7 Length:2754 Species:Danio rerio


Alignment Length:3029 Identity:736/3029 - (24%)
Similarity:1096/3029 - (36%) Gaps:1071/3029 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 EGIAELSLEDVDVDSVPERKPHFL--DYDAVPPPDYEEGF---GASSG--------EQLKMDK-- 61
            |.|.|:||:......|..|....|  ..|:.|.|......   |||||        |:|:.::  
Zfish    70 ERIKEMSLDPSGFSGVKLRSKASLQGSADSSPSPSPVSSCPRRGASSGGRDSAGYLEELEKERSL 134

  Fly    62 ---KYERDGEVSD-YELAASGYTKKEFTQDDNTLHFTQSAVGLGSGAVGKKPAAKHFLDENPIPP 122
               :.|::.:..| |.......||:                                :|..|:..
Zfish   135 LVAELEKEEKEKDWYYAQLQNLTKR--------------------------------IDSLPLTE 167

  Fly   123 DYML------------AQELREMREH-----RSLDRNFERQSAQQQQL--DELPPRN----GGGS 164
            ::.|            |:::|...|.     :.:::..:.:.|:.||:  |.|..|.    ....
Zfish   168 NFSLQTDMTRRQLEYEARQIRAAMEDQLGTCQDMEKRAQGRVARIQQIEKDMLRIRTRLQAQSAE 232

  Fly   165 PASAGRPSRSK---EP-SYTLSRFLDGDAPAPAPR--LPKGAAWTTSFDERYTSSA--------- 214
            ..|:|:..|.:   || |.|......|||.|.|..  ..:|:|.....|.....|:         
Zfish   233 SESSGKRYRERVKHEPLSQTEGSHAAGDAGAAAAASVCSQGSASRVDHDSASEMSSAGSYSVPRR 297

  Fly   215 VEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPDND-- 277
            :.:.||:|||.|||||||||::|..:|::..|.:|.:..||..:|:|||:|||:|::|..|.|  
Zfish   298 LTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCIAMRQSGCLPLLIQLLHGNDKDSV 362

  Fly   278 --------QEVRKCAGQALHNVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIAD 334
                    :|.|..|..||||::||.||:|.||||.:||.||:||..||.......:|....:  
Zfish   363 LLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQESHERGV-- 425

  Fly   335 DSDRHPL---------AAISSLMKVSFDEEHRHAMCELGALHAIPNLVHLDHAVHGPKPEDQCCN 390
            |.|::|:         .|:..|||:||||||||||.|||.|.||..|:.:|..::| ...|....
Zfish   426 DQDKNPMPSPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIGELLQVDCEIYG-LTNDHYSV 489

  Fly   391 SLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMK 455
            :|||||.||||||||||..|||.||..|..|.|:||||.|..:||.||.||||||||||||.|.|
Zfish   490 TLRRYAGMALTNLTFGDVANKATLCSMKGCMRAMVAQLKSESEDLQQVIASVLRNLSWRADVNSK 554

  Fly   456 AVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGP 520
            .:|.|:|:|.||...|:..:.|:|||::|||||||||||:.|||:.|.|.|||||||..|:|...
Zfish   555 KILREVGSVRALMECALEVQKESTLKSVLSALWNLSAHCTENKADICTVPGALAFLVSTLTYRSQ 619

  Fly   521 SKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSAR 585
            :.||.|||:.|||||||||.||..|.:|||||:::||..|||.|||.|||:|||:||||||||||
Zfish   620 TNTLAIIESGGGILRNVSSLIATNEEHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSAR 684

  Fly   586 SAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKALP 650
            :|:||:.|||.|||.||::||||||.||:.||::||:||:..|||...    |....|.| .:||
Zfish   685 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYK----DANIMSPG-SSLP 744

  Fly   651 TLEARKAKALQQELGERHTAETCDNLDT------------------------------------- 678
            :|..||.|||.:||..:|.:||.||:|.                                     
Zfish   745 SLHVRKQKALIEELDAQHLSETFDNIDNLSPKASHRVKPRHKHNVYGDYDAVCRSDGYNPNGVGV 809

  Fly   679 -----------------------------GGKLDKERA--------------------------- 687
                                         ...||:||.                           
Zfish   810 RSPYMNTPVLSSPSSRDNRGNAESVRAERDRSLDRERRGFLPDGEAAKRMMQIPTSAAQIAVVME 874

  Fly   688 ----------SSSSRRHPAPRLTRSAML---TKSESRDSVYS-AKSD-----C--------AYDH 725
                      ..|:...|.|...:..|:   |......::|| :|:|     |        |.:.
Zfish   875 EVQNMHLGMDDRSAGSTPDPHSVQDDMIRRQTAVHGHQNIYSYSKTDPSGRPCPMPKLEYRASND 939

  Fly   726 LIRSASASDAHRK---VKPKITDFDLEME-----------------------QDTEATEEQPIDY 764
            .:.|.:::|.:.|   :||.:..:..:.|                       :|.....:.||:|
Zfish   940 SLNSVNSTDGYGKRGQMKPSVDSYSEDDEGKCCVYRKYPADLAHKIHNANHMEDDNGDLDTPINY 1004

  Fly   765 SVKY--------------------------------------------------SENATKTSTYQ 779
            |:||                                                  ||...|...||
Zfish  1005 SLKYSDEQLNSGRQSPSQNERWARPKLLDDEMKRPDQKPPRSQSPGYPMYTEGSSEGEDKPKKYQ 1069

  Fly   780 ----ETDL------------------------------------DQPTDFSLRYAENQIESDLDI 804
                :.||                                    |:||::|.||:|   |..|:.
Zfish  1070 PRFVQQDLPAFRSRGSNEQISSGSSHGLNKKISQTICSVDDYADDKPTNYSERYSE---EEQLEE 1131

  Fly   805 SGPAGGQKSTITPPAETVPEKSEGQEILLILDDSVKCYQTEDTPYVISNAASVTDLRVAAK---- 865
            ..|:...|.|            |...:...:|.|:|..:......:.|: :..:..:.:||    
Zfish  1132 QTPSYSMKYT------------EDHHVEQPIDYSLKYSEAPSKKGMFSH-SKTSSAQSSAKEHLS 1183

  Fly   866 ---ADAEAEVKPEVRE-------VTSKEGAPKKLPKLSQCGSGSYTPEKPINYCEEGTPGYFSRY 920
               :.:.|.:|.:.|:       ..|:.|..:.:.|...|.:.:...|....||.|.||..|||.
Zfish  1184 QDSSSSVASLKNQGRQKQLHPSSAQSRSGPTRAVQKNPTCKAPTINQETLQTYCVEDTPICFSRG 1248

  Fly   921 DSLSSLD------ESGKANQAIVGTDADIKPKLEKQEEQ------------ESQPA-EQVLTKPP 966
            .|||||.      ||.|.|.    ..|...|.|...|:|            |||.: ..|..|||
Zfish  1249 SSLSSLSSEEDEMESCKRNV----NSASNYPTLPISEKQSTNNVAADQRTSESQSSVHYVRAKPP 1309

  Fly   967 -------------------TQANS----------------ALETPLMFSRRSSMDSLVHDPDVDV 996
                               :.|.|                ..||||||||.:|:.||.......:
Zfish  1310 RHHLGHGDGSRHHKTVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESHSI 1374

  Fly   997 ANCDDKSSVVSD-FSRLASGVISPSEIPDSPTQSMPQS---------PRRNSVAGSGQNVDSPP- 1050
            |     |||.|: .|.:.||:||||::||||.|:||.|         ||..||.   |.|..|| 
Zfish  1375 A-----SSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPPRSTSVK---QKVTVPPH 1431

  Fly  1051 ----------VVIPASLQPLRSVFEDD-LSSFNVEHTPAQFSTATSLSNLSI------------- 1091
                      .|:.|::|.::.:.::| |..|..|.||..||.|:|||.||:             
Zfish  1432 TEKHDLAPRHAVVSAAVQKVQVLPDNDTLLHFATESTPDGFSCASSLSALSLDEPFIQKDVELKI 1496

  Fly  1092 -----VDD------------------EKAPASV---------AEEDNEDELLLANCINMGM---- 1120
                 .||                  ||:||:.         :::|::.|:|.| |||..|    
Zfish  1497 MPPVHEDDHSIEAEPEMEDMHEPKVQEKSPATSEAAKDILDDSDDDDDTEILNA-CINSAMPTKS 1560

  Fly  1121 QRKPTEAVKSTV------VNSEVDV--------------------AEETIRSYCTEDTPALLSKV 1159
            .|||.:...|.:      ..|::.|                    .|:..|.||.|.||...|..
Zfish  1561 SRKPKKQSTSRIPPPVACKPSQLPVYKLLPPQNRGQPQKHVALAHGEDMPRVYCVEGTPINFSTA 1625

  Fly  1160 PSNTNLSVIS-------MSSTDPKDATAGQAQMYAHQLSDDVSSNASDCG-----------GASG 1206
            .|.::|::.|       |.|:.|....:||.:   ..|.:..|:.|.:.|           ....
Zfish  1626 TSLSDLTIDSPPNELAGMESSAPHVEASGQRR---DTLPEGKSAEAKETGLSPPMQSALAENEGD 1687

  Fly  1207 HLLQQCIRDGMKK---------------------PLGEATSDPIAMLRRGGNELPGYLPSADEMN 1250
            .:|.:||...|.|                     ..|......:...:......|  :|.:.|..
Zfish  1688 DILAECINSAMPKSKIHKPFRVQKMPDQAQHPSTATGSLVQQDLEKKKPTSPVKP--MPQSSEYR 1750

  Fly  1251 KFLVEDSPCNFSVVSGLSNLTVGSSLVGPAV---QLKETEPSSADQNP-----EMKAKPGKQEQV 1307
            ..:::....|             :||..||.   :.|||.    .|.|     :...||...|:.
Zfish  1751 ARMLKRPEAN-------------NSLADPATYPDKNKETR----KQEPKVVIRDFADKPSNAEER 1798

  Fly  1308 RRP------PHW------------QDDSLSSLSIDSED--------------------------- 1327
            .||      ||.            ::||||||..:.||                           
Zfish  1799 TRPGFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFEDEDLDFSKEKAVLRKDKEQRKVPLLKCSVE 1863

  Fly  1328 ---DTNLLSQAIAAGC---------NRPKSNLGFSSNGKRSSSLSSSQPIAINAATSASSLNSAM 1380
               :||::|....|..         ..||.|.....:.|:..|:..: |:..:..:|.|||    
Zfish  1864 QPANTNMVSTFQTAPTKPLQKTVFPQAPKENTVVVCDEKQKFSIEDT-PVCFSRNSSLSSL---- 1923

  Fly  1381 TVRKSQQQESYSSVDSSDSNDNQSKSLFELCILKG---MYKTKEPGA-----RAQQMQEQPIVGS 1437
                       |.:|..::|.:        |..|.   ..:...|.|     :|..:::.|:..|
Zfish  1924 -----------SDIDQENNNKD--------CSHKDDVTQMEAPRPQASGYAPKAFHVEDTPVCFS 1969

  Fly  1438 SSVQSNPSLKQFDSLPVQLPSSGQVKRQRHHHHHHHHRERERERKDEKLLQECINTGISKKINAV 1502
                .|.||   .||.:.                          .::.||||||::.:.||....
Zfish  1970 ----RNSSL---SSLSID--------------------------SEDDLLQECISSAMPKKKKQT 2001

  Fly  1503 P------------KNVLATSAAALEPCHPMAATTSASALSTAA--PDVEQ---KAHATSNPQQQS 1550
            |            |:::|....:.||...:..|.:.|.:|..|  ||.|.   ||.........|
Zfish  2002 PRSKTEESGVKEEKSMMADGILSEEPDLILDLTDTHSPISEQALSPDSESFDWKAIQEGANSIVS 2066

  Fly  1551 STHPSSHIL----PNPIDAIATVTD--TVRSP----------AAPNQGNGNASQNGLETATGSKD 1599
            |.|.::..|    .:..|:|.::..  ::.||          .|||:              |.:.
Zfish  2067 SLHQAAASLSRQGSSDSDSILSLKSGISIGSPFHLPLNQDDKPAPNK--------------GPRI 2117

  Fly  1600 LDSEDRSSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKSVERLTMEFVTSAEQ--L 1662
            |...::||.|                        |.:|.::....||..:::....:|...:  |
Zfish  2118 LKPGEKSSIE------------------------AKKKEEETAKSLKGGKKVYKSLITGKPRPSL 2158

  Fly  1663 RSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSFPSVSQTAPVLASL-----------SLDEDATE 1716
            .|.:..|..:.:...:.....         |..|.|..::|..:.:           .....|..
Zfish  2159 ESMASQHRQAQAPVISRGRTM---------VHVPGVRSSSPSTSPVPKKPPPRGQMSKPPSQAPG 2214

  Fly  1717 ARSLHELIEITPTNEQQPESLEGETDTLVNGHADSYSGSSGGLNFQLGGQVQNAGVR-------- 1773
            |.|....:::.|::|..|.|  |...:  .|.:...|..||..:......||.:..|        
Zfish  2215 AGSSPRTMKVPPSSEPSPAS--GPPSS--QGGSSKASSRSGSRDSTPSRPVQQSLTRPMQSPGRA 2275

  Fly  1774 -LEPQRLLFNGTS--------------ASIMTNSTMIAFEAR----ALAENLLQPAATDDDTTEM 1819
             :.|.|   ||.|              ||...:||..:...|    :....|:||..|..     
Zfish  2276 SVSPGR---NGLSPSNKLSQLPQLPRTASPSASSTKSSGSGRMAYTSPGRQLVQPTPTKQ----- 2332

  Fly  1820 TFSLNSLDLDNIRPPSGM-ESLNSCYQDHSQPSSLRQAMPSKSPRFARKMFPANLVARRALGHLA 1883
                           ||: .|.:...:..|....|.|..|||....:|                 
Zfish  2333 ---------------SGLPRSTSGIPRSESASKILNQCGPSKKAELSR----------------- 2365

  Fly  1884 GSAESVNSSCNLLDNIKPPSL--------------MDELLDSMISVDSIQSEVADGEQ------- 1927
              ..|..||.:..|..:.|.|              :...|:...|.:|:........|       
Zfish  2366 --MSSTKSSGSESDRSEKPGLVRQSTFIKEAPSPTLKRKLEESASFESLSPSSTSQSQTPVSSPS 2428

  Fly  1928 --DCSMATTISVSNYETAACDDQTMTVLQSCFDEDEDATMNDYSSAESTPKHGSTPSPNRRSLTP 1990
              |.|::.....|.:..|...       |:..:..:..::..:..:.|   |..:||        
Zfish  2429 LPDMSLSLPYQGSGWTKAPQS-------QNSAENGDGKSLKRHDISRS---HSESPS-------- 2475

  Fly  1991 KDKRRLTKDRFKTYTIATSCEMEAPEANETLQIEIVEAAVPVATPSPR-ANGRRRGSAERYKTQL 2054
                ||..:|..|:      :.|..:.:.:|               || ...:|.||:       
Zfish  2476 ----RLPINRTGTW------KREHSKHSSSL---------------PRVGTWKRTGSS------- 2508

  Fly  2055 IECPLALIQPQPDDCPSEQLSSIRAMMQQFTFITDINIGHSQETCESTDHPEDAGESPECDQNSE 2119
                                |||.:...:.:     ..|.|::..:.|:.|:.:|:....::...
Zfish  2509 --------------------SSILSASSESS-----EKGRSEDERQPTNPPQKSGKEGGLERKGT 2548

  Fly  2120 TESCDGQEPDQLPPPPSIVDLRTSVVKPTTLEPATAVKL-------VRGRKKPAYVSPYSMQS-- 2175
            .....|.|...   .|..:||:.......:......|::       .|..|.|...:|..:.|  
Zfish  2549 WRKAKGSETSY---APMSLDLQDQTGDAMSKSEDVWVRIEDCPINNPRSSKSPTASTPPVIDSLP 2610

  Fly  2176 ------QRNSNNAAPSKKKTLSPTIAKRSLVPGGSGVRLPAKKKPTPPPEPAPARLERQGTFVKD 2234
                  .|:|:.   |..|.:|...|...|   ||...|...:        :...|:::.|.:|.
Zfish  2611 IKGLACDRDSSE---SHSKLMSENAAMSHL---GSETNLNLLR--------SSESLDKKVTDIKP 2661

  Fly  2235 EPTNSNV-----QVPVVETKP-----------------AQTSPTHRASKLPTKKGTASGGSPSKA 2277
            .|:|.|:     :.||.|..|                 |:.||.:....  .:|.:|.|.:|   
Zfish  2662 APSNPNIGPELHEFPVSERTPFSSTNSSKHSSPSGAVAARVSPFNYTPS--PRKSSADGSTP--- 2721

  Fly  2278 GSPKRIPLAPARRMTPQRANTSLRLAAG-KSHAASRVVS 2315
             .|.:||       ||..:|...|...| .:.:.|.:|:
Zfish  2722 -RPSQIP-------TPISSNAKKRDTKGDTTESGSYIVT 2752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 51/103 (50%)
armadillo repeat 258..332 CDD:293788 36/83 (43%)
ARM 332..448 CDD:237987 66/124 (53%)
armadillo repeat 369..403 CDD:293788 14/33 (42%)
armadillo repeat 411..448 CDD:293788 23/36 (64%)
armadillo repeat 498..539 CDD:293788 25/40 (63%)
ARM 506..624 CDD:237987 78/117 (67%)
armadillo repeat 548..582 CDD:293788 24/33 (73%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 3/22 (14%)
APC_crr 903..927 CDD:283553 13/23 (57%)
APC_crr 1066..1090 CDD:283553 12/24 (50%)
APC_crr 1247..1271 CDD:283553 2/23 (9%)
apcNP_001137312.1 APC_N_CC 4..55 CDD:293294
Suppressor_APC 119..198 CDD:288297 13/110 (12%)
ARM 305..407 CDD:237987 49/101 (49%)
ARM 458..591 CDD:237987 77/133 (58%)
armadillo repeat 459..502 CDD:293788 21/43 (49%)
armadillo repeat 510..547 CDD:293788 23/36 (64%)
armadillo repeat 554..589 CDD:293788 17/34 (50%)
armadillo repeat 597..638 CDD:293788 25/40 (63%)
ARM 604..725 CDD:237987 80/120 (67%)
armadillo repeat 647..681 CDD:293788 24/33 (73%)
armadillo repeat 689..723 CDD:293788 21/33 (64%)
Arm_APC_u3 726..996 CDD:293235 44/274 (16%)
APC_u5 1013..1111 CDD:293236 7/97 (7%)
APC_u9 1264..1341 CDD:293239 16/80 (20%)
APC_crr 1344..1367 CDD:283553 10/22 (45%)
APC_crr 1608..1632 CDD:283553 8/23 (35%)
APC_u13 1633..1684 CDD:293240 10/53 (19%)
APC_u14 1705..1804 CDD:293241 19/117 (16%)
APC_crr 1806..1831 CDD:283553 7/24 (29%)
APC_u15 1838..1893 CDD:293242 5/54 (9%)
SAMP 1981..2000 CDD:283554 8/18 (44%)
APC_basic 2172..2506 CDD:283581 71/431 (16%)
EB1_binding 2593..2754 CDD:283565 42/187 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170580925
Domainoid 1 1.000 198 1.000 Domainoid score I3030
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 519 1.000 Inparanoid score I1233
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm6551
orthoMCL 1 0.900 - - OOG6_105450
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.880

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