DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and Odad2

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	XP_038952403.1	Gene:	Odad2 / 307036	RGDID:	1306933	Length:	1073	Species:	Rattus norvegicus

Alignment Length:	873	Identity:	163/873 - (18%)
Similarity:	291/873 - (33%)	Gaps:	324/873 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 EQLKMDKKYERDGE---------VSDYELAASGYTKKEFTQ-------------DDNTLHFTQSA 97
            :.:::.|::...||         .||||. ::|.....:.|             |..||..|.|.
  Rat   238 KDIELLKRFSGKGEQTVLEWIEYTSDYEF-SNGCRAPPWRQIQGEMCYVMVKPHDVETLCLTCST 301

  Fly    98 VG--LGSGAVGKKPAAKH-------------FLDENPIPPDYMLAQELREMREHRSLDRNFERQS 147
            .|  |..|...::.|..:             ..|::|:..:.|..||:|           |..:.
  Rat   302 EGVFLNGGKTEEEGAIDYERKGEVYKDIVTCLKDQSPVFSENMSKQEIR-----------FNEEQ 355

  Fly   148 AQQQQLDELPPRNGGGSPASAGRPSRSKEPSYTLSRFLDGDAPAPAPRLPKGAAWTTSFD----- 207
            .:..|:.|.|....|.|.|:....|:.::..:..|..        ..||.....|..:.|
  Rat   356 QKDSQIFEKPKTEDGPSSATGSEKSKVEKLYFGKSHM--------TKRLEPSLNWRATVDYKDHK 412

  Fly   208 --------------ERYTSSA--------------VEATL------------------------- 219
                          |:.::|.              ||.|:
  Rat   413 SSTKDSQEEKQGKLEKSSTSVSTGRGQLLRKGGEKVEETVSESSSESEEDEEPLDHRQEANADLP 477

  Fly   220 ---------------GSKVECVYSLLSMLGSN---DPLEMA------------------------ 242
                           |::...|.:|.||...|   :..::|
  Rat   478 SEYWQIQKLVKYLKGGNQTATVIALCSMRDFNLAQETCQLAIRDVGGLEVLINLLDTDEVKCKIG 542

  Fly   243 --KKFLELSGNAQSCATLRRS----GCMPLLVQMMHAPDNDQEVRKC-AGQALHNVVHSHPDEKA 300
              |...|:|.|.|    :||:    |.:|::|.::   |:..:..|| |.:.:.||.......:|
  Rat   543 SLKILKEISHNPQ----IRRNIVDLGGLPIMVNIL---DSSHKSLKCLAAETIANVAKFKRARRA 600

  Fly   301 GRRE---AKVLRLLDQIVDYCSFLKTLLQSGGE----AIADDSDRHPLAAISSLMKVSFDEEH-- 356
            .|:.   .|::.|||     |.      |:..|    .:.:..|.. :|...:|...|..:.|
  Rat   601 VRQHGGITKLVALLD-----CG------QNSSEPAQPGLYETRDVE-VARCGALALWSCSKSHSN 653

  Fly   357 RHAMCELGALHAIPNLVHLDH-----AVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALLCG 416
            :.|:.:.|.:..:..|:...|     .|.|...|   |.|               :||.:|.:..
  Rat   654 KEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQE---CAS---------------EENYRAAIKA 700

  Fly   417 QKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSEN--T 479
            :: .:|.||..|:|..:.|.:..|..:...:  .|...:.::...|.:.  .||::.|.::|  .
  Rat   701 ER-IIENLVKNLNSENEQLQEHCAMAIYQCA--EDEETRDLVRLHGGLK--PLASLLNNTDNKER 760

  Fly   480 LKAILSALWNLSAHCSTNK------AEFCAVDGALAFLVGMLSYEGPSKTL-------------- 524
            |.|:..|:|.    ||.:|      .|:.|::    .|||:|: :.|.:.|
  Rat   761 LAAVTGAIWK----CSISKENVIKFREYKAIE----TLVGLLT-DQPEEVLVNVVGALGECCQEY 816

  Fly   525 ---KIIENAGGI--------------LRNVSSHIAVC--EP---------------YRQILRQH- 554
               .::...|||              |.||:..:..|  ||               :..:...|
  Rat   817 ENRVLVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMAIIDRLDGVRLLWSLLKNPHP 881

  Fly   555 -----------NC-----------------LAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQK 591
                       .|                 |.:::..|||::..|:::.|..:.|: |:..|:..
  Rat   882 DVKASAAWALCPCIENAKDAGEMVRSFVGGLELVVNLLKSDNKEVLASVCAAITNI-AKDQENLA 945

  Fly   592 FLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNF---RPAVQNHHQLDPIARSMGLKALPT-L 652
            .:.|:|.||:|..|.::.:..:....:.|:.....:   |.|...|..:.|:.|.  ||:..| :
  Rat   946 VITDHGVVPLLSKLANTNNDKLRRHLAEAISRCCMWGRNRVAFGEHKAVAPLVRY--LKSNDTNV 1008

  Fly   653 EARKAKALQQELGERHTAETCDNLDTGG 680
            ....|:||.| |.|  .|:.|..:...|
  Rat  1009 HRATAQALYQ-LSE--DADNCITMHENG 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	28/130 (22%)
		armadillo repeat	258..332	CDD:293788	20/85 (24%)
		ARM	332..448	CDD:237987	24/122 (20%)
		armadillo repeat	369..403	CDD:293788	7/38 (18%)
		armadillo repeat	411..448	CDD:293788	8/36 (22%)
		armadillo repeat	498..539	CDD:293788	15/77 (19%)
		ARM	506..624	CDD:237987	33/194 (17%)
		armadillo repeat	548..582	CDD:293788	8/62 (13%)
		armadillo repeat	590..624	CDD:293788	7/33 (21%)
		APC_crr	837..860	CDD:283553
		APC_crr	903..927	CDD:283553
		APC_crr	1066..1090	CDD:283553
		APC_crr	1247..1271	CDD:283553
Odad2	XP_038952403.1	PLN03200	<478..713	CDD:215629	53/272 (19%)
		armadillo repeat	483..508	CDD:293788	5/24 (21%)
		armadillo repeat	518..550	CDD:293788	2/31 (6%)
		armadillo repeat	557..593	CDD:293788	11/38 (29%)
		PLN03200	<599..>891	CDD:215629	64/335 (19%)
		armadillo repeat	600..646	CDD:293788	12/57 (21%)
		armadillo repeat	656..688	CDD:293788	7/34 (21%)
		armadillo repeat	694..731	CDD:293788	8/39 (21%)
		armadillo repeat	736..769	CDD:293788	8/34 (24%)
		armadillo repeat	778..814	CDD:293788	8/40 (20%)
		SRP1	<786..1071	CDD:227396	51/259 (20%)
		armadillo repeat	859..896	CDD:293788	2/36 (6%)
		armadillo repeat	912..937	CDD:293788	6/24 (25%)
		armadillo repeat	944..1021	CDD:293788	20/79 (25%)
		HEAT repeat	955..983	CDD:293787	3/27 (11%)
		armadillo repeat	1027..1060	CDD:293788	1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910