DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc and Apc2

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:XP_038934575.1 Gene:Apc2 / 299611 RGDID:1308256 Length:2315 Species:Rattus norvegicus


Alignment Length:2602 Identity:662/2602 - (25%)
Similarity:963/2602 - (37%) Gaps:744/2602 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 SSG--EQLK-MDKKYERDGEVSDYELAASGYTK-----KEFTQDDNTLH---FTQSAVG------ 99
            :||  |.|| :..|.|::..|    |.:||.|:     |....|.::|:   |...|:|      
  Rat    71 TSGMKEVLKHLQGKLEQEARV----LVSSGQTEVLEQLKALQTDISSLYNLKFHAPALGPEPAAQ 131

  Fly   100 --LGSGAVGKKPAAKHF----------LDENPIPPDYMLAQELREMREHRSLDRNFERQSAQQQQ 152
              .||...|..|:...|          |:|......::|::..:|.:|....   :.:.....::
  Rat   132 TPEGSPVHGPAPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWY---YSQLQGLSKR 193

  Fly   153 LDELP------PRNGGGS-PASAGRPSRSKEPSYTLS----RFLDGD-----APAPAPRLPKGAA 201
            |||||      ||:...| .....|.....|..:..|    ||...|     |...|.||.:...
  Rat   194 LDELPHVDTPVPRSQQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDK 258

  Fly   202 WTTSFDERYTSSAVEATL--------------------------GSKVECVYSLLSMLGSNDPLE 240
            ......:|...:..:|.|                          .||||.|:.|||||.:.|..:
  Rat   259 ELLEAQDRVQQTEPQALLAVKPVAVEEQEAEVPTHPEDVTPQPGNSKVEVVFWLLSMLATRDQED 323

  Fly   241 MAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPD-------------NDQEVRKCAGQALHNVV 292
            .|:..|.:|.:.:||..:|||||:|||:|::|..:             ..::.|..|..||||:|
  Rat   324 TARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRTGTPGAPGAKDARMRANAALHNIV 388

  Fly   293 HSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQ---SGGEAIADDS----DRHPLAAISSLMKV 350
            .|.||:...|:|.:||.:|:||..||......||   ||.|:...|:    :.....|..::||:
  Rat   389 FSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKL 453

  Fly   351 SFDEEHRHAMCELGALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALLC 415
            |||||:|.||.|||.|.|:..|:.:|:.:| ...:|....:|||||.|.||||||||..|||.||
  Rat   454 SFDEEYRRAMNELGGLQAVAELLQVDYEMH-KMTQDPLNLALRRYAGMTLTNLTFGDVANKATLC 517

  Fly   416 GQKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTL 480
            .::..|||:||||.|..::|.||.:|:|||||||||.|.|.||.|:|::|||....:|...|:||
  Rat   518 ARRGCMEAIVAQLASESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMECVLRASKESTL 582

  Fly   481 KAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCE 545
            |::||||||||||.:.|||..|.|||||.|||..|:|.....:|.:||:.|||||||||.||..|
  Rat   583 KSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATRE 647

  Fly   546 PYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKH 610
            .|||:||.||||..|||.|.|.|||:|||:|||||||||||..||:.|||.|||.|||:|:||||
  Rat   648 DYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKH 712

  Fly   611 AMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDN 675
            .||:.||::||:|||..|||   .:|...:|.|.| ..:|:|..||.:||:.||..||......:
  Rat   713 KMIAMGSAAALRNLLAHRPA---KYQAAAMAVSPG-TCVPSLYVRKQRALEAELDTRHLVHALGH 773

  Fly   676 LDTGGKLDKERASSSSRRHPAPRLTRSAMLTKSESRDSVYSAKSDCAYDHLIRS-ASASDAHRKV 739
            |:..|..:.|..|    :.|.|.|.....|.:.      |::.|.|..|....| |:|:......
  Rat   774 LEKQGLPEAETTS----KKPLPPLRHLDGLVQD------YASDSGCFDDDDAPSLAAAATTAEPA 828

  Fly   740 KPKITDF---------------------DLEMEQDT------EATEEQPIDYSVKYSENATKTST 777
            .|.:...                     .||.|::|      .|..:..:..:|...:...:..:
  Rat   829 SPAVMSMFLGGPFLQGQALARTPPARQGGLEAEKETGGEAAVAAKAKAKLALAVARIDRLVEDIS 893

  Fly   778 YQETDLDQPTDFSLRYA--------ENQIESDLDISGPAGGQKST-------------------- 814
            ...|..|.  .|||...        |.:.:|.....|..||::..                    
  Rat   894 ALHTSSDD--SFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSND 956

  Fly   815 ----------------ITP-PAETVPEKSEGQEILLILDDSVKCYQTE------DTPYVISNA-- 854
                            :|| |...:.|..:|.          .|.||.      |.|   |.|  
  Rat   957 SLNSGSTSDGYCTREHMTPCPLAVLTEHRDGP----------VCGQTRPSRLDLDLP---SRAEL 1008

  Fly   855 ----ASVTDLRVAAKADAEAEVKPEVREVTSKEGAPKKLPKLSQCGSG----------------- 898
                .:.||.||..     .::.|..:.|...:|||         |:|                 
  Rat  1009 PARDTAATDARVRT-----IKLSPTYQHVPLLDGAP---------GAGVRPLVGLGTSPGTRKQA 1059

  Fly   899 -------SYTPEK------PIN-------YCEEGTPGYFSRYDSLSSLDESGKANQAIVGTDADI 943
                   |..|||      |:.       ..::| |...||..|||||..:|.|..:.|....|.
  Rat  1060 WIPADSLSKVPEKLVASPLPVTSKVLQKLVAQDG-PMSLSRCSSLSSLSSTGHAVPSQVENLDDS 1123

  Fly   944 KPKLEKQEEQESQPAEQVL--------------------------------TKPPTQANSALETP 976
            ...||  |.:|:.|.|..|                                |...:..|...|||
  Rat  1124 DSSLE--ELEEAGPGEAELDRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETP 1186

  Fly   977 LMFSRRSSMDSLVHDPDVDVANCDDKSSVVSD-FSRLASGVISPSEIPDSPTQSMPQSPRRNSVA 1040
            |:.||.||:.||.......:|     ||:.|| .|.|.||.:||||:||||.|:||.|..|...|
  Rat  1187 LVLSRCSSVSSLGSFESRSIA-----SSIPSDPCSALGSGTVSPSELPDSPGQTMPPSRSRTPPA 1246

  Fly  1041 GSGQNVDSPPVVIPASLQ----------------PLRSVFEDDLSS--FNVEHTPAQFSTATSLS 1087
            ..||     |.....|||                ..:...|.|..|  |.||.....||.|:|||
  Rat  1247 PPGQ-----PEASQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLS 1306

  Fly  1088 NLSIVDDEKAPASVAEEDNEDELLLANCINMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDT 1152
            .|::.:      ...::|.|..|....|        |..||.....:...|.|...:      |.
  Rat  1307 ALALHE------LYVQQDVELRLRPPAC--------PERAVGGGGGHRRRDEATSRL------DG 1351

  Fly  1153 PALLSKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGM 1217
            ||     |:.:.    :.|:.| |:..|                            |::|:...|
  Rat  1352 PA-----PAGSR----ARSAAD-KELEA----------------------------LRECLGAAM 1378

  Fly  1218 KKPLGEATSDPIAMLRRGGNELPGYL----PS-ADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLV 1277
            ...|.:..|..:.  .|....:|.|:    |: .|:......|.:|.|||..:.||:.|    |.
  Rat  1379 PARLRKVASALVP--GRRALPVPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDET----LQ 1437

  Fly  1278 GPAVQLKETEPSSADQNPEMKAKPGKQEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCNR 1342
            ||: :.|...|... |.|..:|.|.:|.:..||                       :|..||..:
  Rat  1438 GPS-RDKPARPGDR-QKPTGRAAPARQTRGHRP-----------------------KAAGAGAGK 1477

  Fly  1343 PKSNLGFSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSS-DSNDNQSKS 1406
            ...:...::..:....|..|:|                       |.:.|:.|.| .:......:
  Rat  1478 STEHTRGANRNRAGLELPLSRP-----------------------QSARSNRDGSCQTRTRGDGA 1519

  Fly  1407 LFELCIL----KGMY----KTKEPGARAQQMQEQPIVGSSSVQSNPSLKQFDSLPVQLPSSGQVK 1463
            |..||:.    :.:|    ..:||.|.|                 |..::..::|..|       
  Rat  1520 LQSLCLTTPTEEAVYCFYDSDEEPPATA-----------------PPTRRASAIPRAL------- 1560

  Fly  1464 RQRHHHHHHHHRERERERKD--EKLLQECINTGISKKINAVPKNVLATSAAALEPCHPMAATTSA 1526
                      .||:...||:  .:..|..     :..:.|.|:.::..:    .||:.:  |:||
  Rat  1561 ----------KREKPAGRKETPTRATQPA-----TLPVRAQPRLIVDET----PPCYSL--TSSA 1604

  Fly  1527 SALSTAAPDVEQKAHATSNPQ---QQSSTHPSSHILPNPIDAIATVTDT------------VRSP 1576
            |:||......:...|.....|   |.||......:|...|........|            |||.
  Rat  1605 SSLSEPEASEQPACHPRVEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPSSRRRKPRAVRSD 1669

  Fly  1577 AAPNQGNGNASQNGLETATGS---KDLDS-EDRSSDESNQSFIMETMVRLDSALNETCISGASEK 1637
            ..|.:    ..|...|...||   .|||| |.::..|...|.:        :.|::.....:.|.
  Rat  1670 IRPTE----LPQKCREEVPGSDPASDLDSVEWQAIQEGANSIV--------TWLHQAAAKASLEA 1722

  Fly  1638 HKDPDLMLKSVERLTMEFVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSFPSVSQTA 1702
            ..:.|.:|..|..|:........:||......:        .:...|.          |....|.
  Rat  1723 SSESDSLLSLVSGLSASSTLQPSKLRKGRKPVA--------EAGGAWR----------PEKRGTT 1769

  Fly  1703 PVLASLSLDEDATEARSLHELIEITPTNEQQPESLEGETDT------LVNGHADSYSGSSGGLNF 1761
            ....|.|                  |.....||..:|...|      ::.|....|:.|.     
  Rat  1770 STKGSGS------------------PRFPSGPEKAKGTQKTMAGESAMLRGRTVIYTASP----- 1811

  Fly  1762 QLGGQVQNAGVR---LEPQRLLFNGTSASIMTNSTMIAFEARALAENLLQP------AATDDDTT 1817
              ..:.|:.|:.   ..|:::..:||:.......|....:.|  :.:|.:|      ||......
  Rat  1812 --ASRAQSKGISGPCSAPKKMGTSGTTQPETATKTPSPEQQR--SRSLHRPGKISELAALSHPPR 1872

  Fly  1818 EMTFSLNSLDLDNIRPPSGMESLNSCYQDHSQPSSLRQAMPSKSPRFARKMFPANLVARRALGHL 1882
            ..|            ||:.:....|.....:.|:|  |::|.:||           :|....|.|
  Rat  1873 SAT------------PPARLTKTPSSSSSQTSPAS--QSLPRRSP-----------LATPTGGPL 1912

  Fly  1883 AGSAESVNSSCNLLDNIKPPSLMDELL-------DSMISVDSIQSEV------------------ 1922
            .|...|.          .|.|....||       .|.:.:..:|...                  
  Rat  1913 PGPGGSP----------VPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRG 1967

  Fly  1923 ---ADGEQDC--SMATTISVSNYETAACD--DQTMTVLQSCFDEDEDATM----NDYSSAESTPK 1976
               |:|....  |....:.|::..::..:  |::....|..|.::....:    ::.|||:||..
  Rat  1968 RAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVS 2032

  Fly  1977 HGSTPSPNR-RSLTPKDKRRLTKDRFKTYTIATSCEMEAPEANETLQIEIVEAAVPVATP--SPR 2038
            ...|.||.| |...|           ..:..::.|:    |...:.:..:....||.|.|  :||
  Rat  2033 TSQTASPCRGRPALP-----------AVFLCSSRCD----ELRASPRQPLAAQRVPQAKPGLAPR 2082

  Fly  2039 ANGRRRGSAERYKTQLIECPLALIQPQPDDCPSEQLSSIRAMMQQFTFITDINIGHSQETCESTD 2103
            |  .||.|:|                .|...|..........::::..:..|::..         
  Rat  2083 A--PRRTSSE----------------SPSRLPVRATPGRPETVKRYASLPHISVSR--------- 2120

  Fly  2104 HPEDAGESPECDQNSETESCDGQE---PDQLPPPPS---IVDLRTSVVKPTTLEPATAVKLVRGR 2162
            .|:.|...|....|:.....||:.   |....|..:   |.|.....:..:|| ||||:.| ||.
  Rat  2121 RPDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRRIKDEDVPHILRSTL-PATALPL-RGS 2183

  Fly  2163 KKPAYVSPYSMQSQRNSNNAAPSKKKTLSPTIAKRSLVPGGSGVRLPAKKKPTPPPEPAPARLER 2227
            ....  ||.....::.|:....::....|.|.:..|          |:.:...||..|....:  
  Rat  2184 SPED--SPAGTPHRKTSDAVVQTEDVATSKTNSSTS----------PSLESRDPPQAPISGPV-- 2234

  Fly  2228 QGTFVKDEPTNSNVQVPVVETKPAQTSPTHRASKLPTKKGTASGGSP-SKAGSPKRIPLAPARRM 2291
                   .|..|:|..||:...||....||....:.|      ||.| |:.|||.|....|....
  Rat  2235 -------APLGSDVDGPVLAKPPASAPFTHEGLSVVT------GGFPTSRHGSPSRAARVPPFNY 2286

  Fly  2292 TP 2293
            .|
  Rat  2287 VP 2288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 42/106 (40%)
armadillo repeat 258..332 CDD:293788 34/89 (38%)
ARM 332..448 CDD:237987 56/119 (47%)
armadillo repeat 369..403 CDD:293788 12/33 (36%)
armadillo repeat 411..448 CDD:293788 20/36 (56%)
armadillo repeat 498..539 CDD:293788 23/40 (58%)
ARM 506..624 CDD:237987 76/117 (65%)
armadillo repeat 548..582 CDD:293788 24/33 (73%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 8/34 (24%)
APC_crr 903..927 CDD:283553 11/36 (31%)
APC_crr 1066..1090 CDD:283553 11/25 (44%)
APC_crr 1247..1271 CDD:283553 8/23 (35%)
Apc2XP_038934575.1 APC_N_CC 34..85 CDD:374728 5/13 (38%)
Suppressor_APC 152..239 CDD:402843 18/89 (20%)
APC_rep 390..463 CDD:408568 27/72 (38%)
armadillo repeat 462..505 CDD:293788 19/43 (44%)
armadillo repeat 513..550 CDD:293788 20/36 (56%)
armadillo repeat 559..592 CDD:293788 17/32 (53%)
armadillo repeat 600..641 CDD:293788 23/40 (58%)
Arm 647..686 CDD:395413 28/38 (74%)
armadillo repeat 650..684 CDD:293788 24/33 (73%)
Arm 688..728 CDD:395413 25/39 (64%)
armadillo repeat 692..728 CDD:293788 23/35 (66%)
Arm_APC_u3 729..975 CDD:406922 49/261 (19%)
APC_r 1175..1198 CDD:399133 9/22 (41%)
APC_r 1287..1308 CDD:399133 10/20 (50%)
APC_r 1411..1433 CDD:399133 7/21 (33%)
PHA03247 <1538..1963 CDD:223021 98/561 (17%)
SAMP 1632..1653 CDD:399134 3/20 (15%)
APC_basic 1798..2130 CDD:399151 71/417 (17%)
EB1_binding <2242..>2290 CDD:399141 17/53 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341034
Domainoid 1 1.000 190 1.000 Domainoid score I3179
eggNOG 1 0.900 - - E1_KOG2122
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 612 1.000 Inparanoid score I875
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm9133
orthoMCL 1 0.900 - - OOG6_105450
Panther 1 1.100 - - LDO PTHR12607
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.750

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