DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc and Apc

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:XP_006254568.1 Gene:Apc / 24205 RGDID:2123 Length:2870 Species:Rattus norvegicus


Alignment Length:2981 Identity:738/2981 - (24%)
Similarity:1084/2981 - (36%) Gaps:1093/2981 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 LDENPIPPDYML------------AQELREMREH-----RSLDRNFERQSAQQQQL--DELPPRN 160
            :|..|:..::.|            |:::|...|.     :.:::..:|:.|:.||:  |.|..|.
  Rat   177 IDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRVRQ 241

  Fly   161 GGGSPAS-AGRPSRSKE--PSYTLSRFLDGDAPAPAPRLPKG------------------AAWTT 204
            ...|.|: |.|.|:||.  .|:...|.|:|...|.:.....|                  ::.|.
  Rat   242 LLQSQAAEAERSSQSKHETASHEAERQLEGQGVAESNLATSGSGQSSAARVDHETAGVLSSSGTH 306

  Fly   205 SFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQ 269
            |...|.||.     ||:|||.|||||||||::|..:|::..|.:|.:..||.::|:|||:|||:|
  Rat   307 SAPRRLTSH-----LGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQ 366

  Fly   270 MMHAPDND----------QEVRKCAGQALHNVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTL 324
            ::|..|.|          :|.|..|..||||::||.||:|.||||.:||.||:||..||......
  Rat   367 LLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEW 431

  Fly   325 LQSGGEAIADDSDRHPL---------AAISSLMKVSFDEEHRHAMCEL----------------- 363
            .::..:.:  |.|::|:         .|:..|||:||||||||||.||                 
  Rat   432 QEAHEQGM--DQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGRKATRGISPQELGQGL 494

  Fly   364 -GALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQ 427
             |.|.||..|:.:|..:|| ..:|....:|||||.||||||||||..|||.||..|..|.|||||
  Rat   495 SGGLQAIAELLQVDCEMHG-LTDDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQ 558

  Fly   428 LDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSA 492
            |.|..:||.||.||||||||||||.|.|..|.|:|:|.||...|:..:.|:|||::|||||||||
  Rat   559 LKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSA 623

  Fly   493 HCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCL 557
            ||:.|||:.||||||||||||.|:|...:.||.|||:.|||||||||.||..|.:|||||::|||
  Rat   624 HCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL 688

  Fly   558 AILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALK 622
            ..|||.|||.|||:|||:||||||||||:.:||:.|||.|||.||::||||||.||:.||::||:
  Rat   689 QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALR 753

  Fly   623 NLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLD---------- 677
            ||:..|||...    |....|.| .:||:|..||.|||:.||..:|.:||.||:|          
  Rat   754 NLMANRPAKYK----DANIMSPG-SSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRS 813

  Fly   678 ----------------------------TG---------------------GKLDKERASS---- 689
                                        ||                     |.||..|:..    
  Rat   814 KQRHKQNLYGDYVFDASRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSL 878

  Fly   690 ------------SSRRHPAPRLTR------------------SAMLTKSESRDSVYSAKSDC--- 721
                        |:..:|.....|                  ||:.|..:.|....:|:..|   
  Rat   879 ERERGIGLSTYHSATENPGTSSKRGLQLSATAAQIAKVMEEVSALHTSQDDRSPASAAELHCVAE 943

  Fly   722 ----------AYDH-------------------------------LIRSASASDAHRK---VKPK 742
                      ::.|                               .:.|.::||.:.|   :||.
  Rat   944 ERTAARRSSASHTHPNTHNFAKSESSNRTCSMPYAKVEYKRSSNDSLNSVTSSDGYGKRGQMKPS 1008

  Fly   743 ITDFDLEME-----------------------QDTEATEEQPIDYSVKYSE---NATKTSTYQ-- 779
            :..:..:.|                       .|.....:.||:||:|||:   |:.:.|..|  
  Rat  1009 VESYSEDDEGKFCSYGQYPADLAHKIHSANHMDDNGGELDTPINYSLKYSDEQLNSGRQSPSQNE 1073

  Fly   780 ---------ETDL---------DQPTDFSLRYAENQIESDLDISGPAGGQKSTITP--------- 817
                     |.::         .|.|:|.: |:||..:..|... ...||:..::|         
  Rat  1074 RWARPKHVIEDEIKQNEQRQSRSQNTNFPV-YSENTDDKHLKFQ-QHFGQQECVSPYRSRGTNGS 1136

  Fly   818 -----------------------------P---AETVPEKSEGQEILLILDDSVKCYQTE----D 846
                                         |   :|...|:.:.:|.....:.|:| |..|    |
  Rat  1137 ETNRMGSSHAVNQNVNQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIK-YNEEKHHVD 1200

  Fly   847 TP--YVISNAASVTDLRVAAKADAEAEVKPEVREVTSKEGAPK---------------------- 887
            .|  |.:..|   ||:..:.|........|.|:...::..:|.                      
  Rat  1201 QPIDYSLKYA---TDISSSQKPSFSFSKTPSVQGTKTEHNSPSSEAASAPSSNAKRQSQLHPSSA 1262

  Fly   888 ----KLPKLSQCGSGSYTPEKPINYCEEGTPGYFSRYDSLSSL----DESG------KANQAIVG 938
                :.||.:.|...|...|....||.|.||..|||..|||||    ||.|      :|:.|...
  Rat  1263 QRNGQTPKGTACKVPSINQETMQTYCVEDTPICFSRCSSLSSLSSAEDEIGCDQTTQEADSANTL 1327

  Fly   939 TDADIKPK---LEKQEEQESQPA--EQVLTKPPTQANSAL------------------------- 973
            ..|:||..   ...|:.....||  :...|||.....|.|                         
  Rat  1328 QIAEIKENDVTRSAQDPASDVPAVSQSTRTKPSRLQASGLASESARHKAVEFSSGAKSPSKSGAQ 1392

  Fly   974 -----------ETPLMFSRRSSMDSLVHDPDVDVANCDDKSSVVSD-FSRLASGVISPSEIPDSP 1026
                       ||||:|||.:|:.||.......:|     |||.|: .|.:.||::|||::||||
  Rat  1393 TPKSPPEHYVQETPLVFSRCTSVSSLDSFESRSIA-----SSVQSEPCSGMVSGIVSPSDLPDSP 1452

  Fly  1027 TQSMPQS----------------------------------PRRNSVAGSGQNVDSPPVVIPASL 1057
            .|:||.|                                  |::.:|:.:.|.|.    |:|.: 
  Rat  1453 GQTMPPSRSKTPPPPPPPQPVQTKREVPKTKVPAAEQREGGPKQTAVSAAVQRVQ----VLPDA- 1512

  Fly  1058 QPLRSVFEDDLSSFNVEHTPAQFSTATSLSNLSIVDDE---------KAPASVAEEDNEDELLLA 1113
                    |.|..|..|.||..||.::|||.||:  ||         :....|.|.||.:|    
  Rat  1513 --------DTLLHFATESTPDGFSCSSSLSALSL--DEPFIQKDVELRIMPPVQENDNGNE---- 1563

  Fly  1114 NCINMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDTPALLSKVPSNTNLSVISMSSTDPKDA 1178
                                 :|.:..||:     .|:....:.|..|..:|       .|..| 
  Rat  1564 ---------------------TEPEQPEES-----NENQDKEVEKPDSEKDL-------LDDSD- 1594

  Fly  1179 TAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGM-------KKPLGEATS---DPIAMLR 1233
                        .||:            .:|::||...|       .|.|.:..|   .|:|   
  Rat  1595 ------------DDDI------------EILEECIISAMPTKSSRKAKKLAQTASKLPPPVA--- 1632

  Fly  1234 RGGNELPGY--LPSADEMNK---------------FLVEDSPCNFSVVSGLSNLTVGSSLVGPAV 1281
            |..::||.|  |||...:..               :.||.:|.|||..:.||:||:.|    |..
  Rat  1633 RKPSQLPVYKLLPSQSRLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIES----PPN 1693

  Fly  1282 QLKETEPSSAD-QNPEMKAKPGKQEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCNRPKS 1345
            :|...:...|. |:.|.:.:.....:.|.....|...:||::|...|.:......|.|.|     
  Rat  1694 ELAAGDGVRASVQSGEFEKRDTIPTEGRSTDEAQRGKVSSIAIPDLDGSKAEEGDILAEC----- 1753

  Fly  1346 NLGFSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQ--SKSLF 1408
                                 ||:|......:....|:|...|...:|:.||.:|.||  :|...
  Rat  1754 ---------------------INSALPKGRSHKPFRVKKIMDQVQQASMTSSGTNKNQIDTKKKK 1797

  Fly  1409 ELCILKGMYKTKEPGARAQQMQEQPI-------------VGSSSVQSNPSLKQF-DSLPVQLPSS 1459
            ....:|.|.:..|...|.::..:..:             ....|:::||  |.. |.||   .:.
  Rat  1798 PTSPVKPMPQNTEYRTRVRKNTDSKVNVNTEETFSDNKDSKKQSLKNNP--KDLNDKLP---DNE 1857

  Fly  1460 GQVKRQRHHHHHHHHRERER-----ERKD--EKLLQECINTGISKKINAVPKNVLATSAAALEPC 1517
            .:|:........||:...|.     .|.|  ..|..:..:..:|::...:.|...:..:.|...|
  Rat  1858 DRVRGGFTFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKGKESKDSEAKVTC 1922

  Fly  1518 HPMAATTSASALSTAAPDVEQKAHATSNPQQQSSTHPSSHILPNPIDAIATVTDTVRSPAAPNQG 1582
            |...:::..||         :||       |.|:.||.:                 |.|:.|   
  Rat  1923 HTEPSSSQQSA---------RKA-------QASTKHPVN-----------------RGPSKP--- 1951

  Fly  1583 NGNASQNGLETATGSKDLDSEDRSSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKS 1647
               ..|........|||:.....::||..|:|.:|.        ...|.|               
  Rat  1952 ---LLQEQPTFPQSSKDVPDRGAATDEKLQNFAIEN--------TPVCFS--------------- 1990

  Fly  1648 VERLTMEFVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSFPSVSQTAP--------- 1703
                           |:||.:..|....:||:     ||.|.|...:.|:.:|..|         
  Rat  1991 ---------------RNSSLSSLSDVDQENNN-----NEETGPVRDAEPANAQGQPGKPQASGYA 2035

  Fly  1704 -----------------VLASLSLDEDATEARSLHELIEITPTNEQQPESLEGETDTLVNGHADS 1751
                             .|:|||:|   :|...|.|.|......:::|..|:||           
  Rat  2036 PKSFHVEDTPVCFSRNSSLSSLSID---SEDDLLQECISSAMPKKRRPSRLKGE----------- 2086

  Fly  1752 YSGSSGGLNFQLGGQVQNAGVRLEPQRLLFNGTSASIMTNSTMIAFEARALAENLLQPAATDDDT 1816
                               |.|..|:::                   ...|||:|          
  Rat  2087 -------------------GERQSPRKV-------------------GSVLAEDL---------- 2103

  Fly  1817 TEMTFSLNSLDLDNIRPPSGMESLNSCYQD----------HSQPSSLRQAMPSKSPRFARKMFPA 1871
                    :|||.:|:.|.....|:...::          :|..|||.||..:           |
  Rat  2104 --------TLDLKDIQRPESEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAA-----------A 2149

  Fly  1872 NLVARRALGHLAGSAESVNSSCNL--------------LDNIKPPSLMDELLDSMISVDSIQSE- 1921
            ..::|:|... :.|..|:.|..:|              ..:.|.|.::.....|.:....|:|| 
  Rat  2150 ACLSRQASSD-SDSILSLKSGVSLGSPFHLTPDQEEKPFTSHKGPRILKPGEKSTLEAKKIESEN 2213

  Fly  1922 --VADGEQDCSMATTISV-SNYETAACDDQTMTVLQSCFDE-DEDATM-------NDYSSAESTP 1975
              :..|::......|..: ||.|.::   |....||:.... ....||       |..||.....
  Rat  2214 KGIKGGKKVYKSLITGKIRSNSEISS---QMKQPLQTNMPSISRGRTMIHIPGVRNSSSSTSPVS 2275

  Fly  1976 KHG---STPSPNRRSLTPKDKRRLTKDRFKTYTIATSCEMEAPEANETLQIEIVEAAVPVATPSP 2037
            |.|   .||:    |.:|.:.                                     ||||.||
  Rat  2276 KKGPPLKTPA----SKSPSEG-------------------------------------PVATTSP 2299

  Fly  2038 RANGRRRGSAERYKTQLIECPLALIQPQPDDCPSEQLSSIRAMMQQFTFITDINIGHSQE-TCES 2101
                  ||:....|::|  .|:.                     :|.:.|:..|.|.|:. :.:|
  Rat  2300 ------RGTKPAVKSEL--SPIT---------------------RQTSHISGSNKGPSRSGSRDS 2335

  Fly  2102 TDHPEDAGESPECDQNSETESCDGQEPDQLPPPPSIVDLRTSVVKPT-------TLEPATAVKLV 2159
            |  |....:.|.            ..|.|.|...||...|..:..|.       |..|:||....
  Rat  2336 T--PSRPTQQPL------------SRPMQSPGRNSISPGRNGISTPNKLSQLPRTSSPSTASTKS 2386

  Fly  2160 RGRKKPAYVSPYSMQSQRN---------------------------SNNAAPSKKKTLSPTIAKR 2197
            .|..|.:|.||....||:|                           :|:...:||..||...:.:
  Rat  2387 SGSGKMSYTSPGRQLSQQNLSKQTGLSKNASSIPRSESASKGLNQMNNSNGSNKKVELSRMSSTK 2451

  Fly  2198 SLVPGGSGVRLPAKKKPTPPPEPAPARLERQGTFVK--------------------------DEP 2236
            |     ||......::|.         |.||.||:|                          |.|
  Rat  2452 S-----SGSESDRSERPA---------LVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPDSP 2502

  Fly  2237 TNSNVQVPVVE-TKPAQTSPTHRA------SKLPTKKGTA---SGGSPSK--------AGSPKRI 2283
            |.|..|.||:. :.|..:..||.:      .|||......   |.|.|||        :.||.|:
  Rat  2503 TRSQAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYSDGRPSKRHDIARSHSESPSRL 2567

  Fly  2284 PLAPA---------------RRMTPQRANTSLRLAAGKSHAASRVVS-----------------G 2316
            |:..|               |..|.:|..:|..:.:..|.::.:..|                 .
  Rat  2568 PVNRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSVPGPRQMKEN 2632

  Fly  2317 RV----------SSTTPPSRSNSNLNGSSAAAAAAAK-----INHAQSRIANIWKRVDEAKTKQS 2366
            :|          .|...|:.:.|....|.||:.|.:|     :..|.|:..::|.|:::...   
  Rat  2633 QVPTKGTWRKIKESEISPTNTVSQTTSSGAASGAESKTLIYQMAPAVSKTEDVWVRIEDCPI--- 2694

  Fly  2367 SSNLRTQKTKSSN------MLNANG------TKPTLLRSSTFDNTPSTAGGVKSKL 2410
             :|.|:.::.:.|      .::..|      :|.|..:.|....:|....|::::|
  Rat  2695 -NNPRSGRSPTGNTPPVIDSISEKGNPSIKDSKDTQGKQSVGSGSPVQTVGLENRL 2749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 51/103 (50%)
armadillo repeat 258..332 CDD:293788 35/83 (42%)
ARM 332..448 CDD:237987 68/142 (48%)
armadillo repeat 369..403 CDD:293788 15/33 (45%)
armadillo repeat 411..448 CDD:293788 24/36 (67%)
armadillo repeat 498..539 CDD:293788 28/40 (70%)
ARM 506..624 CDD:237987 79/117 (68%)
armadillo repeat 548..582 CDD:293788 25/33 (76%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 9/28 (32%)
APC_crr 903..927 CDD:283553 14/27 (52%)
APC_crr 1066..1090 CDD:283553 11/23 (48%)
APC_crr 1247..1271 CDD:283553 8/38 (21%)
ApcXP_006254568.1 Suppressor_APC 135..215 CDD:288297 9/54 (17%)
ATP-synt_B <200..283 CDD:304375 26/105 (25%)
ARM 319..421 CDD:237987 49/120 (41%)
ARM 495..623 CDD:237987 82/127 (65%)
armadillo repeat 498..534 CDD:293788 22/35 (63%)
armadillo repeat 542..579 CDD:293788 29/36 (81%)
armadillo repeat 589..621 CDD:293788 22/31 (71%)
armadillo repeat 629..670 CDD:293788 28/40 (70%)
ARM 637..757 CDD:237987 63/194 (32%)
armadillo repeat 679..713 CDD:293788 12/33 (36%)
armadillo repeat 721..757 CDD:293788 17/110 (15%)
Arm_APC_u3 758..1045 CDD:293235 96/521 (18%)
APC_u5 1062..1161 CDD:293236 39/142 (27%)
APC_crr 1282..>1299 CDD:283553 5/19 (26%)
APC_u9 1308..1393 CDD:293239 22/100 (22%)
APC_crr 1663..1687 CDD:283553 5/23 (22%)
APC_u13 1688..1744 CDD:293240 8/55 (15%)
SAMP 1745..1764 CDD:283554 6/18 (33%)
APC_u14 1765..1865 CDD:293241 17/125 (14%)
APC_u15 1902..1973 CDD:293242 16/94 (17%)
SAMP 2061..2080 CDD:283554 0/18 (0%)
APC_basic 2251..2596 CDD:283581 64/325 (20%)
EB1_binding 2698..2870 CDD:283565


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341032
Domainoid 1 1.000 84 1.000 Domainoid score I8062
eggNOG 1 0.900 - - E1_KOG2122
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 612 1.000 Inparanoid score I875
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm9133
orthoMCL 1 0.900 - - OOG6_105450
Panther 1 1.100 - - O PTHR12607
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.840

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