DRSC/TRiP Functional Genomics Resources

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Protein Alignment Apc and Ctnnd2

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:NP_032755.2 Gene:Ctnnd2 / 18163 MGIID:1195966 Length:1246 Species:Mus musculus


Alignment Length:1218 Identity:264/1218 - (21%)
Similarity:420/1218 - (34%) Gaps:362/1218 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LEPTLTPDLE------EGIAELSLEDVDVDSVPERKPHFLDYDAVPPPDYEEG---FGAS--SGE 55
            :|..||..||      ..:.|..:.|....|..|| |..|...|:......||   :.||  |.:
Mouse   112 IEDELTTGLELVDSCIRSLQESGILDPQDYSTSER-PSLLSQSALQLNSKPEGSFQYPASYHSNQ 175

  Fly    56 QLKMDKKYERDGEVSDYELAASGYTKKEFTQDDNTLHFTQSAVGLGSGAVGKKPAAKHFLDENPI 120
            .|.:       |:.:..:|.|.....:...|.     |:|...|......|.:||..      |.
Mouse   176 TLAL-------GDTAPSQLPARSTQARAAGQS-----FSQGTTGRAGHLAGSEPAPP------PP 222

  Fly   121 PPDYMLAQELREMREHRSLDRNFERQSA--------QQQQLDELPPRNG-------GGSPASAGR 170
            ||....|.         ||...|....|        ........|||.|       ||||....|
Mouse   223 PPREPFAP---------SLGSAFHLPDAPPAAAALYYSSSTLPAPPRGGSPLTTTQGGSPTKLQR 278

  Fly   171 PSRSKE-PSYTLSRFLDGDAPAPAP-RLPKGAAWTTSFDERYTSSA------------VEATLGS 221
            ...:.| .:|...|   |.:|..:| ||.|..: |:|......|||            |::|:.|
Mouse   279 GGSAPEGAAYAAPR---GSSPKQSPSRLAKSYS-TSSPINIVVSSAGLSPIRVTSPPTVQSTISS 339

  Fly   222 KVECVYSLLSMLGSNDPLEMAKKFL----ELSGNAQ---SCATLRRSGCMPLLVQMMHAPDNDQE 279
            ..  ::.|.|.:|:...|...|:.:    :.|.::|   :.|||:|.|.:               
Mouse   340 SP--IHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSL--------------- 387

  Fly   280 VRKCAG-QALHNVVHSH--PDEKAGRR-EAKVLRLLDQIVDYCSFLKTLLQSGGEAI-------- 332
               .|| :|.::..|.|  |:.:|.:. |..:..:.:..|.....:::|.||.|:.:        
Mouse   388 ---AAGSRASYSSQHGHLAPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTF 449

  Fly   333 ----ADDS---DRHPL-----------AAISSLMKVS--------FDEEHRH------------- 358
                |..|   |..||           ||.::..:.|        :.:.:|.             
Mouse   450 RTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCASVDSPYSK 514

  Fly   359 ---AMCELGALHAIPNLVHLDHAVHGPK---------PE-----DQCCNSLRRYALMALTNLTFG 406
               |:...|.|...|:   :|.....|:         ||     .....|::..|...|.:|.||
Mouse   515 SGPALPPEGTLARSPS---IDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFG 576

  Fly   407 DENNKALLCGQKQFMEALVAQLDSAPDDLLQVTASVLRNLSW-RADSNMKAVLNEIGTVTALALA 470
            |...||.:..|.. ::.||..||....::.:.....||||.: :|:.:.|..|...|.:.||...
Mouse   577 DNKIKAEIRRQGG-IQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRL 640

  Fly   471 AMRNRSENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVG--MLSYEG----PSK------- 522
            ..:.......:.:...|||||: |...|...  :..|||.|..  ::.:.|    |.:       
Mouse   641 LRKTTDLEIRELVTGVLWNLSS-CDALKMPI--IQDALAVLTNAVIIPHSGWENSPLQDDRKIQL 702

  Fly   523 -TLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLA-ILLQQLKS-------ESLTVVSNSCGT 578
             :.:::.||.|.||||||   ..|..|:.:|:.:.|. .||..::|       :|.||.:..| .
Mouse   703 HSSQVLRNATGCLRNVSS---AGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVC-I 763

  Fly   579 LWNLSARSA------------------------------------------EDQ----------- 590
            |.|||.|.|                                          :||           
Mouse   764 LRNLSYRLAAETSQGQHMGTDELDGLLCGETNGKDTESSGCWGKKKKKKKSQDQWDGVGPLPDCA 828

  Fly   591 ------KFLWDNGAV-PMLRSLIHSKHAMISEGSSSALKNLL--NFRPAVQNHHQLDPIARSM-- 644
                  :.||....| |.|..|....:....||::.||:||.  :::...::...:....||:  
Mouse   829 EPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKGWAEDVAGMAYALRSLPE 893

  Fly   645 GLKALPTLEARKAKALQQELGERHTAETCDNLDTGGKLDKER---ASSSSRRHPAPRLTRSAMLT 706
            |...||........|:::|.|.....|..       ::|.:|   |.:::.|:.|..:....::.
Mouse   894 GAPCLPQWSVYIRAAVRKEKGLPILVELL-------RIDNDRVVCAVATALRNMALDVRNKELIG 951

  Fly   707 KSESRDSVYSAKSDCAYDHLIRSASASDAHRKVKPKITDFDLEMEQDTE----ATEEQPIDYSVK 767
            |...||.|:         .|....:::::..|.          |..||.    .|..:.|   .|
Mouse   952 KYAMRDLVH---------RLPGGNNSNNSGSKA----------MSDDTVTAVCCTLHEVI---TK 994

  Fly   768 YSENATKTSTYQETDLDQPTDFSLRYAENQIESDLDISGPAGGQKS-TITPPAETVPE------- 824
            ..|||.                :||.| ..||..:.||...|.:.| .:...|..|..       
Mouse   995 NMENAK----------------ALRDA-GGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRD 1042

  Fly   825 -----KSEGQEILLILDDSVKCYQTEDTPYVISNAASVTDLRVAA-KADAEAEVKPEVREVTS-K 882
                 |.:|......:..|....:....||..|...|::.:||:. ...|.|...|  ||:.| |
Mouse  1043 LRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASP--REMISLK 1105

  Fly   883 EGAPKKLPKLSQCGSGSYTPEKPINYCEEGTPG-YFSRYDSLSSLDESGKAN--QAIVGTDA-DI 943
            |   :|....|...:.:|          .||.| :.||.|:::: ..:|.:.  :...|..| ||
Mouse  1106 E---RKTDYESAGNNATY----------HGTKGEHTSRKDTMTA-QNTGVSTLYRNSYGAPAEDI 1156

  Fly   944 KPKLEKQEEQESQPAEQVLTKPPTQANSALETPLMFSRRSSMDSLVHD 991
                 ||.:..:||..|    .|::.:.....|...|.|:..:|...|
Mouse  1157 -----KQNQVSTQPVPQ----EPSRKDYETYQPFPNSTRNYDESFFED 1195

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 20/104 (19%)
armadillo repeat 258..332 CDD:293788 16/77 (21%)
ARM 332..448 CDD:237987 35/179 (20%)
armadillo repeat 369..403 CDD:293788 8/47 (17%)
armadillo repeat 411..448 CDD:293788 11/36 (31%)
armadillo repeat 498..539 CDD:293788 14/54 (26%)
ARM 506..624 CDD:237987 44/199 (22%)
armadillo repeat 548..582 CDD:293788 11/41 (27%)
armadillo repeat 590..624 CDD:293788 11/51 (22%)
APC_crr 837..860 CDD:283553 5/22 (23%)
APC_crr 903..927 CDD:283553 6/24 (25%)
APC_crr 1066..1090 CDD:283553
APC_crr 1247..1271 CDD:283553
Ctnnd2NP_032755.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 133..237 29/131 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 255..308 18/55 (33%)
ARM 1 390..432 8/41 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..479 10/50 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 513..532 4/21 (19%)
ARM 2 536..575 7/38 (18%)
ARM 540..662 CDD:237987 30/122 (25%)
armadillo repeat 548..573 CDD:293788 5/24 (21%)
ARM 3 578..617 11/39 (28%)
armadillo repeat 581..617 CDD:293788 11/36 (31%)
ARM 4 622..662 9/39 (23%)
armadillo repeat 625..660 CDD:293788 7/34 (21%)
armadillo repeat 667..718 CDD:293788 12/52 (23%)
ARM 5 678..720 10/41 (24%)
ARM 6 724..769 13/45 (29%)
ARM 7 831..871 12/39 (31%)
armadillo repeat 834..871 CDD:293788 12/36 (33%)
ARM 835..962 CDD:237987 30/142 (21%)
ARM 8 903..942 8/45 (18%)
armadillo repeat 906..940 CDD:293788 8/40 (20%)
ARM 907..1039 CDD:237987 35/177 (20%)
armadillo repeat 947..993 CDD:293788 11/67 (16%)
ARM 9 996..1039 14/59 (24%)
armadillo repeat 999..1034 CDD:293788 11/51 (22%)
CAF20 <1050..1109 CDD:293657 16/63 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1063..1130 20/81 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1175 9/32 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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