DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and apr-1

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	NP_001021547.1	Gene:	apr-1 / 172591	WormBaseID:	WBGene00000156	Length:	1188	Species:	Caenorhabditis elegans

Alignment Length:	1297	Identity:	276/1297 - (21%)
Similarity:	465/1297 - (35%)	Gaps:	377/1297 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 DNDQEVRKCAGQALHN----VVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADD 335
            ::|.::|:     ||.    ::.|..|....||..|.|...:.:.:...:|:.     ..:....
Worm    89 EDDNKLRE-----LHEKIFALITSESDVNRKRRLKKALPASNCVREQVYYLRR-----KPSTPPA 143

  Fly   336 SDRHPL-AAISSLMKVSFDEEHRHAMCELGALHAIPNLVHLD---HAVHGPKPEDQCCNSLRRYA 396
            |..|.| ||:.:::|.||.||:|.....||.:.|:..::.|:   ..::...|.:.  .::|:..
Worm   144 SYYHRLNAALHTIVKESFGEEYRKVATVLGLVEALAEVLILEVHTFGINETNPGEH--RNIRKLI 206

  Fly   397 LMALTNLTFGDENNKALLCGQKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEI 461
            ..||||||:|..::|..||....|:..:|..:..:| ::.||.|.::|||||.|||.|...|..
Worm   207 ANALTNLTYGQIHSKRRLCSYDGFIRCVVRIVIESP-NITQVYAGLIRNLSWNADSGMSEALQP- 269

  Fly   462 GTVTALALAAMRNRSEN-TLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLK 525
             ||.||::||:...:.. .:.|.|||||||:.|...||...|.....|..|..:||.:  ::...
Worm   270 -TVHALSIAAVHAHTHRFDVTATLSALWNLAGHSVENKRTICDTPNCLKVLASLLSPD--ARFTS 331

  Fly   526 IIENAGGILRNVSSHIAVCEPY---RQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSARSA 587
            ::::|.|||:.||.::|....:   |.:|     :..:|..|||.|.|.|:|:.|.:.||..:..
Worm   332 LVDSATGILKYVSQYLANTSTHLELRSLL-----ITRMLTLLKSASFTCVTNTLGAIANLIVKDP 391

  Fly   588 EDQKFL-WDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNH----HQLDPIARSMGLK 647
            ..|:.: .|..||..|..|.:|....|.....|.| |.|| :|....:    |.:...|..|.:.
Worm   392 HMQQMIRQDMAAVQQLNVLRNSNRDDIRTAVKSVL-NTLN-QPCSHRYGDMSHSVGGGATGMQML 454

  Fly   648 ALPTLEARKA---------------KALQQELGERHTAETCDNLDTGGKLDKERASSSSRRHPAP 697
            :.|.|:.:.:               :|.:...|:....:....|....::|:.  |||..||.|.
Worm   455 SEPQLQMQTSHHAYHGTASPRLLSLRATRASPGKYIQPQAQQQLIQTPQVDQR--SSSLPRHFAV 517

  Fly   698 RLTRSAM-------LTKSESRDSVY----------SAKSDCAYDH-------------------- 725
            :.....|       :.:.:.:..:|          ..:.....:|
Worm   518 QRNGFVMAQSYNQQMDQHQQQQMIYQLQQQQQIMFQTEDQAQMEHHQQIMYLQQQQQQFHQIQQQ 582

  Fly   726 -LIRSASASDAHRKVKPKITDFDLEM------------------------------EQDTEATEE 759
             .::.|..:|   .|.|  ||.||::                              ..||.|...
Worm   583 QQMQKAQEAD---PVPP--TDDDLDIPTSTVMGTRSNSERSLGSMNPGSVMTNWNSSLDTAANSS 642

  Fly   760 Q---PIDYS-----------VKYSENATKTSTYQETDLDQ-PTDFSLRYAENQIESDLDISGPAG 809
            :   |:.|:           |.....:|::..:|.|...| .|.:|...|.....||...:.|
Worm   643 RALSPVSYNDIPASPTMCAQVFNLPKSTESEHHQLTSQQQNTTHYSSGSANTMTRSDGATTVP-- 705

  Fly   810 GQKSTITP--------------PAETVPEKSEGQEILLILDDSV--KCYQTEDTPYVISNAASVT 858
             ..:.|||              |..|||.|:  .|.|...||.:  ...:.|:..|.|...|
Worm   706 -MDNIITPTYAILNPILVHEQTPNGTVPRKT--SEELDSPDDVLPGPSLEEEEGDYAIIGGA--- 764

  Fly   859 DLRVAAKADAEAEVKPEVREVTSKEGAPKKLPKLSQCGSGSYTPEK----------------PIN 907
                |.|.|.|...:....|:.:....||.  |:|...:|.::|.:                |.:
Worm   765 ----AQKTDDELLTRSIQSEMPTSSSTPKM--KVSPRLNGFFSPTQKTTSSPAWSHPDTSPIPKS 823

  Fly   908 YCEEGTPGYFSRYDS-----------LSSLDESGKANQAIVGTDADIKPKLEKQEEQESQPAEQV 961
            ......|.  .|.|:           :|.:.:|...:..:.||...::|:.|::...:::.|:
Worm   824 SSHRTQPN--RRQDASDADRLLMESIMSEMPKSRIISPRLAGTQQYLEPEPERRSHSKNEEAD-- 884

  Fly   962 LTKPPTQANSALETPLMFSRRSSMDSLVHDPD----VDVANCDDKSSVVSDFSRLASGVISPSEI 1022
                               ||.:. :..|:|.    :|||...|.
Worm   885 -------------------RRDAF-TASHEPSDHNGIDVARGSDW-------------------- 909

  Fly  1023 PDSPTQSMPQSPRRNSVAGSGQNVDSPPVVIPASLQPLRSVFEDDLSSFNVEHTPAQFSTATSLS 1087
              ||.|.:.:.....|.|.|                      ||   ||.:.......||:.:.:
Worm   910 --SPQQQLHRMESLESQASS----------------------ED---SFGLTAEEPNSSTSGAAA 947

  Fly  1088 NLSIVDDEKAPASVAEEDNEDELLLANCINMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDT 1152
            |....|||           .|..|..:|::                :.:.|...:....|..|:.
Worm   948 NTMRFDDE-----------IDASLPMDCVD----------------DDDYDYTYDHFEDYEDEED 985

  Fly  1153 PALLSKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGM 1217
            |                       |||.....:.| ||:.|.|..:|..|.:..:......||
Worm   986 P-----------------------DATQFDDGVDA-QLTIDCSMISSGSGSSQRNETTTTSRD-- 1024

  Fly  1218 KKPLGEATSDPIAMLRRGGNELPGYLPSADEMNKFLVEDSPCNFSVVSGLSNLTV---GSSLVGP 1279
            .|.|  |||.|    :...:.||| :..|..::             .:|.|.|.|   ..|||.
Worm  1025 SKAL--ATSTP----KGSASSLPG-VRQATRVS-------------TNGKSRLPVPKTNGSLVD- 1068

  Fly  1280 AVQLKETEPSSADQNPEMKAKPGKQEQVRRPPHWQDDSLSSLSIDSEDDTNLL-SQAIAAGCNRP 1343
                |..:|..|.:.|.:..||...:....|   ::||:.:   .:.|||..: :..:.|...|.
Worm  1069 ----KNPKPIIASRRPRLPPKPTLLKDKHYP---EEDSIEN---QTRDDTIYVNAPVVEAEQERI 1123

  Fly  1344 KSN-LGFSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQS 1404
            ..| |....|.::|.|:.:..|||          .||:....:.|:..::..::.:.::.:|
Worm  1124 YMNALKQQKNIEQSPSIGNGSPIA----------KSAIVTPYNYQKPPFTGRNNGEMSNEKS 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	10/44 (23%)
		armadillo repeat	258..332	CDD:293788	11/60 (18%)
		ARM	332..448	CDD:237987	36/119 (30%)
		armadillo repeat	369..403	CDD:293788	6/36 (17%)
		armadillo repeat	411..448	CDD:293788	12/36 (33%)
		armadillo repeat	498..539	CDD:293788	11/40 (28%)
		ARM	506..624	CDD:237987	34/121 (28%)
		armadillo repeat	548..582	CDD:293788	11/33 (33%)
		armadillo repeat	590..624	CDD:293788	10/34 (29%)
		APC_crr	837..860	CDD:283553	5/24 (21%)
		APC_crr	903..927	CDD:283553	5/50 (10%)
		APC_crr	1066..1090	CDD:283553	6/23 (26%)
		APC_crr	1247..1271	CDD:283553	2/23 (9%)
apr-1	NP_001021547.1	armadillo repeat	221..257	CDD:293788	12/36 (33%)
		armadillo repeat	306..345	CDD:293788	11/40 (28%)
		ARM	312..431	CDD:237987	37/127 (29%)
		armadillo repeat	354..386	CDD:293788	11/36 (31%)
		VIR_N	<756..898	CDD:292534	29/174 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002986
OrthoInspector	1	1.000	-	-		otm14695
orthoMCL	1	0.900	-	-		OOG6_105450
Panther	1	1.100	-	-	LDO	PTHR12607
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930