DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and Jup

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	NP_034723.1	Gene:	Jup / 16480	MGIID:	96650	Length:	745	Species:	Mus musculus

Alignment Length:	798	Identity:	148/798 - (18%)
Similarity:	256/798 - (32%)	Gaps:	254/798 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LLSMLGSNDPLEMAKKFLELSGNAQSCATLRR-SGCMPLLVQMMHAPDN--DQEVRKCAGQALHN 290
            |..:|...||:.:.|..:.::..::..|:.|. .|...|:..::....|  |.:..:|....|||
Mouse   147 LTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHN 211

  Fly   291 VVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDSDRHPLAAISSLMKVSFDEE 355
            :.|        .||.               |..:.:|||
Mouse   212 LSH--------HREG---------------LLAIFKSGG-------------------------- 227

  Fly   356 HRHAMCELGALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNK---ALLCGQ 417
                         ||.||.:   :..|      ..|:..||:..|.||....|..|   .|..|
Mouse   228 -------------IPALVRM---LSSP------VESVLFYAITTLHNLLLYQEGAKMAVRLADG- 269

  Fly   418 KQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKA 482
               ::.:|..|:......|.:|...|:.|:: .:...|.::...|....| :..|||.|...|..
Mouse   270 ---LQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQGL-VQIMRNYSYEKLLW 329

  Fly   483 ILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPY 547
            ..|.:..:.:.|.:||.......|..|     |.....|.:.::::|....|||:|......|..
Mouse   330 TTSRVLKVLSVCPSNKPAIVEAGGMQA-----LGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGL 389

  Fly   548 RQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHS---- 608
            ..:|:      ||:.||..:.:.|::.:.|||.||:..:::::..:..|..|   .:|||:
Mouse   390 ESVLK------ILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGV---EALIHAILRA 445

  Fly   609 -KHAMISEGSSSALKNLLNFRP---AVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHT 669
             ....|:|.:..||::|.:..|   ..||..:|     :.|:.|:       .|.|.|
Mouse   446 GDKDDITEPAVCALRHLTSRHPEAEMAQNSVRL-----NYGIPAI-------VKLLNQ------- 491

  Fly   670 AETCDNLDTGGKLDKERASSSSRRHPAPRLT----RSAMLTKSESRDSVYSAKSDCAYDHLIRSA 730
                                 ..:.|..:.|    |:..|               |..:|.....
Mouse   492 ---------------------PNQWPLVKATIGLIRNLAL---------------CPANHAPLQE 520

  Fly   731 SASDAHRKVKPKITDFDLEMEQDTE----ATEEQPIDYSVKYSENATKTSTYQETDLDQPTDFSL 791
            :|      |.|::....::..||.:    |..:||....|:..|
Mouse   521 AA------VIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEE--------------------- 558

  Fly   792 RYAENQIESDLDISGPAGGQKSTITPPAETVPEKSEGQEILLILD--DSVKCYQTEDTP-YVISN 853
                                          :.|...|...:|..|  :.::.::....| :|...
Mouse   559 ------------------------------IVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLL 593

  Fly   854 AASVTDL-RVAAKADAEAEVKPEVREVTSKEGAPKKLPKLSQC---GSGSYTPEKPINYCEEGTP 914
            .:||.:: ||||....|.....|..:....|||...|.:|...   |:.:|.........|:..|
Mouse   594 YSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNP 658

  Fly   915 GYFSRYDSLSSLDESGKANQAIVGTDADIKPKLEKQEEQESQPAEQV--LTKPPTQANSALETPL 977
            .|..|                   ...::...|.|.:....:.|:.:  :.:|......|...|
Mouse   659 DYRKR-------------------VSVELTNSLFKHDPAAWEAAQSMIPINEPYADDMDATYRP- 703

  Fly   978 MFSRRSSMDSLVHDPDVD 995
            |:|....:|.|....|:|
Mouse   704 MYSSDVPLDPLDMHMDLD 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	18/89 (20%)
		armadillo repeat	258..332	CDD:293788	16/76 (21%)
		ARM	332..448	CDD:237987	21/118 (18%)
		armadillo repeat	369..403	CDD:293788	9/33 (27%)
		armadillo repeat	411..448	CDD:293788	9/39 (23%)
		armadillo repeat	498..539	CDD:293788	9/40 (23%)
		ARM	506..624	CDD:237987	30/122 (25%)
		armadillo repeat	548..582	CDD:293788	9/33 (27%)
		armadillo repeat	590..624	CDD:293788	9/38 (24%)
		APC_crr	837..860	CDD:283553	4/23 (17%)
		APC_crr	903..927	CDD:283553	4/23 (17%)
		APC_crr	1066..1090	CDD:283553
		APC_crr	1247..1271	CDD:283553
Jup	NP_034723.1	ARM 6	342..381		10/43 (23%)
		armadillo repeat	345..380	CDD:293788	9/39 (23%)
		ARM 7	383..420		12/42 (29%)
		armadillo repeat	393..418	CDD:293788	9/30 (30%)
		ARM 8	423..464		10/43 (23%)
		armadillo repeat	426..464	CDD:293788	10/40 (25%)
		ARM 9	470..510		11/79 (14%)
		armadillo repeat	470..508	CDD:293788	11/77 (14%)
		ARM 10	512..551		9/44 (20%)
		armadillo repeat	515..572	CDD:293788	14/113 (12%)
		Interaction with DSC1. /evidence=ECO:0000250	574..661		19/86 (22%)
		armadillo repeat	577..611	CDD:293788	8/33 (24%)
		armadillo repeat	618..652	CDD:293788	7/33 (21%)
		Adaptin_N	<120..>289	CDD:366724	40/216 (19%)
		Interaction with DSC1 and DSG1. /evidence=ECO:0000250	132..297		43/224 (19%)
		armadillo repeat	144..169	CDD:293788	5/21 (24%)
		armadillo repeat	186..212	CDD:293788	5/25 (20%)
		armadillo repeat	221..253	CDD:293788	12/79 (15%)
		ARM	221..253	CDD:214547	12/79 (15%)
		armadillo repeat	261..297	CDD:293788	9/39 (23%)
		ARM 5	298..341		9/43 (21%)
		armadillo repeat	305..338	CDD:293788	8/33 (24%)
		PLN03200	<328..>658	CDD:215629	82/455 (18%)
		ARM	341..381	CDD:214547	11/44 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910