| Sequence 1: | NP_001263046.1 | Gene: | Apc / 44642 | FlyBaseID: | FBgn0015589 | Length: | 2417 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001078927.1 | Gene: | CTNND1 / 1500 | HGNCID: | 2515 | Length: | 968 | Species: | Homo sapiens |
| Alignment Length: | 1037 | Identity: | 206/1037 - (19%) |
|---|---|---|---|
| Similarity: | 339/1037 - (32%) | Gaps: | 336/1037 - (32%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1 MLEPTLTPDLEEG--IAELSLE-----DVDVDSVPERKPHFLDYDAVPPPDYEEGFGASSGEQLK 58
Fly 59 MDKKYERDGEVSDYELAASGYTKKE----------FTQDDNTLHFTQSAVGLGSGAVGKKPAAKH 113
Fly 114 FLDENPIPPD-------YMLAQELREMREHRSLDRNFERQSAQQQQLDELPPRNGG-----GSPA 166
Fly 167 SAGRPSRSKEPSYTLSRFLDGDAPAPAPRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYSLLS 231
Fly 232 MLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQ----MMHAPDNDQEVRKCAGQALHNVV 292
Fly 293 HSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDS---------DRHPLAAISSLM 348
Fly 349 K---------------------VSFDEEHRHA------MC--------ELGALHAIPNLVH-LDH 377
Fly 378 AVHGPKPEDQCCNSLRRYALMALTNLTFG-DENNKALL--CGQKQFMEALVAQLDSAPD-DLLQV 438
Fly 439 TASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRN--------------RSENTLKAILSALWN 489
Fly 490 LSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSK--TLKIIENAGGILRNVS-------------- 538
Fly 539 -----------SHIAVC--------------------------------EPYR--QILRQHNCLA 558
Fly 559 ILLQQLK-SESLTVVSNSCGTLWNLSA---------RSAEDQKFLWDNGAVPMLRSLIHSKHAMI 613
Fly 614 SEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDN-LD 677
Fly 678 TGGKLDKERASSSSRRHPAPRLTRSAMLTKSESRD--SVYSA----------------------- 717
Fly 718 KSDCAYDHLIRSASASDAHRKVKPKITDFDLEMEQDTEATEEQPIDYSVKYSENATKTSTYQETD 782
Fly 783 LDQPTDFSLRYAENQIESDLDISGPAGGQKSTITPPAETVP-EKSEGQEIL------LILDD 837 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Apc | NP_001263046.1 | ARM | 222..316 | CDD:237987 | 18/97 (19%) |
| armadillo repeat | 258..332 | CDD:293788 | 16/77 (21%) | ||
| ARM | 332..448 | CDD:237987 | 43/164 (26%) | ||
| armadillo repeat | 369..403 | CDD:293788 | 13/34 (38%) | ||
| armadillo repeat | 411..448 | CDD:293788 | 14/39 (36%) | ||
| armadillo repeat | 498..539 | CDD:293788 | 12/67 (18%) | ||
| ARM | 506..624 | CDD:237987 | 37/188 (20%) | ||
| armadillo repeat | 548..582 | CDD:293788 | 9/36 (25%) | ||
| armadillo repeat | 590..624 | CDD:293788 | 7/33 (21%) | ||
| APC_crr | 837..860 | CDD:283553 | 1/1 (100%) | ||
| APC_crr | 903..927 | CDD:283553 | |||
| APC_crr | 1066..1090 | CDD:283553 | |||
| APC_crr | 1247..1271 | CDD:283553 | |||
| CTNND1 | NP_001078927.1 | Necessary and sufficient for interaction with CCDC85B. /evidence=ECO:0000269|PubMed:25009281 | 1..357 | 72/391 (18%) | |
| Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:P30999 | 299..306 | 1/6 (17%) | |||
| ARM 1 | 358..395 | 2/36 (6%) | |||
| ARM | 363..481 | CDD:237987 | 36/130 (28%) | ||
| armadillo repeat | 368..393 | CDD:293788 | 2/24 (8%) | ||
| ARM 2 | 398..437 | 15/48 (31%) | |||
| armadillo repeat | 401..437 | CDD:293788 | 15/45 (33%) | ||
| ARM 3 | 441..475 | 12/36 (33%) | |||
| armadillo repeat | 444..479 | CDD:293788 | 12/37 (32%) | ||
| ARM 4 | 476..516 | 7/39 (18%) | |||
| armadillo repeat | 486..537 | CDD:293788 | 6/50 (12%) | ||
| Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:P30999 | 521..528 | 1/6 (17%) | |||
| ARM | 524..>588 | CDD:237987 | 17/63 (27%) | ||
| ARM 5 | 534..573 | 9/38 (24%) | |||
| Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:P30999 | 568..575 | 1/6 (17%) | |||
| ARM 6 | 583..624 | 7/40 (18%) | |||
| Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:P30999 | 622..629 | 0/6 (0%) | |||
| ARM 7 | 653..693 | 11/39 (28%) | |||
| armadillo repeat | 656..693 | CDD:293788 | 10/36 (28%) | ||
| ARM | 657..759 | CDD:237987 | 29/117 (25%) | ||
| ARM 8 | 700..739 | 12/48 (25%) | |||
| armadillo repeat | 703..737 | CDD:293788 | 10/38 (26%) | ||
| ARM 9 | 740..780 | 7/45 (16%) | |||
| armadillo repeat | 744..787 | CDD:293788 | 9/48 (19%) | ||
| ARM 10 | 781..826 | 7/44 (16%) | |||
| armadillo repeat | 793..829 | CDD:293788 | 5/35 (14%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 855..944 | 23/103 (22%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||