| Sequence 1: | NP_001263046.1 | Gene: | Apc / 44642 | FlyBaseID: | FBgn0015589 | Length: | 2417 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001091679.1 | Gene: | CTNNB1 / 1499 | HGNCID: | 2514 | Length: | 781 | Species: | Homo sapiens |
| Alignment Length: | 895 | Identity: | 168/895 - (18%) |
|---|---|---|---|
| Similarity: | 307/895 - (34%) | Gaps: | 246/895 - (27%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 51 ASSGEQLKMDKKYERDGEVSDYELAASGYTKKEFTQDDNTLHFTQSAVGLGSGAVGKKPAAKHFL 115
Fly 116 DENPIPPDYMLAQELREMREHRSLDRNFERQSAQQQQLDELPPRNGGGSPASAGRPSRSKEPSYT 180
Fly 181 LSRFLDGDAPAPAPRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKF 245
Fly 246 L-----------------------ELSGNAQSCATLRRSGCMPLLVQMMHAPDNDQEVRKCAGQA 287
Fly 288 LHNVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDSDRHPLAAISSLMKVSF 352
Fly 353 DEEHRHAMCELGALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNK--ALLC 415
Fly 416 GQKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTL 480
Fly 481 KAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCE 545
Fly 546 PYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAV-PMLRSLIHS- 608
Fly 609 KHAMISEGSSSALKNLLN-------FRPAVQNHHQLDPIAR-------------SMGL------- 646
Fly 647 ----------KALPTLEARKAKALQQELGERHTAETCDNLDTGGKLDKERASSSSRRHPAPRLTR 701
Fly 702 SAMLTKSESR-----DSVYSAKSD---------CAYDHLIRSASASDAHRKVKPKITDFDLEMEQ 752
Fly 753 DTEAT----------EEQPIDYSVKYSENATKT------STYQET-DL---------------DQ 785
Fly 786 PTDFSLR---YAENQIESDLDISGPAGGQKSTITPPAETVPEKSEGQEIL 832 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Apc | NP_001263046.1 | ARM | 222..316 | CDD:237987 | 19/116 (16%) |
| armadillo repeat | 258..332 | CDD:293788 | 17/73 (23%) | ||
| ARM | 332..448 | CDD:237987 | 24/117 (21%) | ||
| armadillo repeat | 369..403 | CDD:293788 | 6/33 (18%) | ||
| armadillo repeat | 411..448 | CDD:293788 | 10/38 (26%) | ||
| armadillo repeat | 498..539 | CDD:293788 | 11/40 (28%) | ||
| ARM | 506..624 | CDD:237987 | 29/119 (24%) | ||
| armadillo repeat | 548..582 | CDD:293788 | 9/33 (27%) | ||
| armadillo repeat | 590..624 | CDD:293788 | 6/35 (17%) | ||
| APC_crr | 837..860 | CDD:283553 | |||
| APC_crr | 903..927 | CDD:283553 | |||
| APC_crr | 1066..1090 | CDD:283553 | |||
| APC_crr | 1247..1271 | CDD:283553 | |||
| CTNNB1 | NP_001091679.1 | Interaction with VCL. /evidence=ECO:0000250 | 2..23 | 5/25 (20%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 34..57 | 7/24 (29%) | |||
| SRP1 | 142..>431 | CDD:227396 | 82/375 (22%) | ||
| ARM 1 | 151..191 | 3/39 (8%) | |||
| armadillo repeat | 153..178 | CDD:293788 | 0/24 (0%) | ||
| Interaction with BCL9. /evidence=ECO:0000269|PubMed:17052462 | 156..178 | 0/21 (0%) | |||
| armadillo repeat | 188..221 | CDD:293788 | 9/32 (28%) | ||
| ARM 2 | 193..234 | 12/63 (19%) | |||
| armadillo repeat | 230..262 | CDD:293788 | 14/79 (18%) | ||
| ARM | 230..262 | CDD:214547 | 14/79 (18%) | ||
| ARM 3 | 235..276 | 17/88 (19%) | |||
| armadillo repeat | 270..306 | CDD:293788 | 10/38 (26%) | ||
| ARM 4 | 277..318 | 9/44 (20%) | |||
| armadillo repeat | 312..347 | CDD:293788 | 8/35 (23%) | ||
| ARM 5 | 319..360 | 11/41 (27%) | |||
| ARM | 350..390 | CDD:214547 | 14/44 (32%) | ||
| armadillo repeat | 354..389 | CDD:293788 | 11/39 (28%) | ||
| ARM 6 | 361..389 | 10/32 (31%) | |||
| ARM 7 | 400..441 | 11/40 (28%) | |||
| armadillo repeat | 402..427 | CDD:293788 | 9/24 (38%) | ||
| Arm | 431..473 | CDD:395413 | 7/41 (17%) | ||
| armadillo repeat | 435..473 | CDD:293788 | 7/37 (19%) | ||
| ARM 8 | 442..484 | 7/41 (17%) | |||
| armadillo repeat | 482..517 | CDD:293788 | 6/34 (18%) | ||
| ARM 9 | 489..530 | 3/40 (8%) | |||
| armadillo repeat | 524..582 | CDD:293788 | 8/57 (14%) | ||
| ARM 10 | 531..571 | 7/39 (18%) | |||
| Arm | 583..622 | CDD:395413 | 3/38 (8%) | ||
| armadillo repeat | 587..621 | CDD:293788 | 3/33 (9%) | ||
| ARM 11 | 594..636 | 6/41 (15%) | |||
| armadillo repeat | 629..662 | CDD:293788 | 7/34 (21%) | ||
| ARM 12 | 637..666 | 6/30 (20%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 705..781 | 10/59 (17%) | |||
| Interaction with SCRIB. /evidence=ECO:0000250 | 772..781 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||