DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc and Ctnnd1

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	XP_006498688.1	Gene:	Ctnnd1 / 12388	MGIID:	105100	Length:	967	Species:	Mus musculus

Alignment Length:	1040	Identity:	210/1040 - (20%)
Similarity:	340/1040 - (32%)	Gaps:	343/1040 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLEPTLTPDLEEG--IAELSLE-----DVDVDSVPERKPHFLDYDAVPPPDYEEGFGASSGEQLK 58
            |...|||...:.|  :.:..||     |:.::. |:...|.| |..:|
Mouse    55 MANGTLTRRHQNGRFVGDADLERQKFSDLKLNG-PQDHNHLL-YSTIP----------------- 100

  Fly    59 MDKKYERDGEVSDYELAASGYTKKE----------FTQDDNTLHFTQSAVGLGSGAVGKKPAAKH 113
               :.:..|::      ...||:::          .|.||.|...|::.|         |...|.
Mouse   101 ---RMQEPGQI------VETYTEEDPEGAMSVVSVETTDDGTTRRTETTV---------KKVVKT 147

  Fly   114 FLDE--NPIP--PDYMLAQELREMREH-RSLDRNFERQSAQQQQLDELPPRNGGGSPASAGRPSR 173
            ....  .|:|  ||.:..........: ::|.|:|.              :||.|.|.    |..
Mouse   148 MTTRTVQPVPMGPDGLPVDASAVSNNYIQTLGRDFR--------------KNGNGGPG----PYV 194

  Fly   174 SKEPSYTLSRFL----DGDAPAPAPRLPKGA------AWTTSFDERYTSSAVEATLGSKVECVYS 228
            .:..:.||.|..    ||.........|.|:      :..|..:|||..| :|.......:.||.
Mouse   195 GQAGTATLPRNFHYPPDGYGRHYEDGYPGGSDNYGSLSRVTRIEERYRPS-MEGYRAPSRQDVYG 258

  Fly   229 LLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQ----MMHAPDNDQEVRKCAGQALH 289
                         .:..:.:.|   |...|.|....|..::    .|...|.|..:....|.|..
Mouse   259 -------------PQPQVRVGG---SSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARR 307

  Fly   290 NVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDS---------DRHPLAAIS 345
            ....|.|     ||.   ||..:.::             ||.:..|.         :|..||::.
Mouse   308 TGTPSDP-----RRR---LRSYEDMI-------------GEEVPPDQYYWAPLAQHERGSLASLD 351

  Fly   346 SLMK---------------------VSFDEEHRHA------MC--------ELGALHAIPNLVH- 374
            ||.|                     ...|....:|      :|        ::..|..||.||.
Mouse   352 SLRKGMPPPSNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPILVGL 416

  Fly   375 LDHAVHGPKPEDQCCNSLRRYALMALTNLTFG-DENNKALL--CGQKQFMEALVAQLDSAPD-DL 435
            |||    ||.|      :...|..||.|::|| |::||..:  |   ..:.|||..|..|.| ||
Mouse   417 LDH----PKKE------VHLGACGALKNISFGRDQDNKIAIKNC---DGVPALVRLLRKARDMDL 468

  Fly   436 LQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRN--------------RSENTLKAILSA 486
            .:|....|.|||......|:.|.:.:..:|...:.....              ..|:.|......
Mouse   469 TEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGC 533

  Fly   487 LWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSK--TLKIIENAGGILRNVS----------- 538
            |.|:|:..|..:.:....||.:..|:.::..|...|  ..|::||...:|||:|
Mouse   534 LRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAE 598

  Fly   539 --------------SHIAVC--------------------------------EPYR--QILRQHN 555
                          .|.|.|                                .|.|  ::|.|..
Mouse   599 RYQEALPTVANSTGPHAASCFGAKKGKDEWFSRGKKPTEDPANDTVDFPKRTSPARGYELLFQPE 663

  Fly   556 CLAILLQQLK-SESLTVVSNSCGTLWNLSA---------RSAEDQKFLWDNGAVPMLRSLIHSKH 610
            .:.|.:..|| |::..::..|.|.:.||.|         |||     |....|:..:..|:.|:|
Mouse   664 VVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSA-----LRQEKALSAIAELLTSEH 723

  Fly   611 AMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDN 675
            ..:.:.:|.||:||     ||...::     ..:|..|:|.| .:.....||......:.:|..:
Mouse   724 ERVVKAASGALRNL-----AVDARNK-----ELIGKHAIPNL-VKNLPGGQQNSSWNFSEDTVVS 777

  Fly   676 -LDTGGKLDKERASSSSRRHPAPRLTRSAMLTKSESRD--SVYSA-------------------- 717
             |:|..::..|...::.:......:.:..::.||.:|.  .|.:|
Mouse   778 ILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKE 842

  Fly   718 ---KSDCAYDHLIRSASASDAHRKVKPKITDFDLEMEQDTEATEEQPIDYSVKYSENATKTSTYQ 779
               |||  :...:.:||.|.:..    ...|..|.:....:.::::|....:..|...:.|.:
Mouse   843 GWKKSD--FQVNLNNASRSQSSH----SYDDSTLPLIDRNQKSDKKPDREEIPMSNMGSNTKS-- 899

  Fly   780 ETDLDQPTDFSLRYAENQIESDLDISGPAGGQKSTITPPAETVP-EKSEGQEIL------LILDD 837
               ||  .::|...........||.||..|..:     |.:..| .:.||||.|      |:|||
Mouse   900 ---LD--NNYSTLNERGDHNRTLDRSGDLGDME-----PLKGAPLMQDEGQESLEEELDVLVLDD 954

Fly 838 837
Mouse 955 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	18/97 (19%)
		armadillo repeat	258..332	CDD:293788	16/77 (21%)
		ARM	332..448	CDD:237987	43/164 (26%)
		armadillo repeat	369..403	CDD:293788	13/34 (38%)
		armadillo repeat	411..448	CDD:293788	14/39 (36%)
		armadillo repeat	498..539	CDD:293788	12/67 (18%)
		ARM	506..624	CDD:237987	38/188 (20%)
		armadillo repeat	548..582	CDD:293788	9/36 (25%)
		armadillo repeat	590..624	CDD:293788	8/33 (24%)
		APC_crr	837..860	CDD:283553	1/1 (100%)
		APC_crr	903..927	CDD:283553
		APC_crr	1066..1090	CDD:283553
		APC_crr	1247..1271	CDD:283553
Ctnnd1	XP_006498688.1	armadillo repeat	368..393	CDD:293788	2/24 (8%)
		ARM	397..437	CDD:214547	15/49 (31%)
		armadillo repeat	401..437	CDD:293788	15/45 (33%)
		Arm	440..481	CDD:395413	16/43 (37%)
		armadillo repeat	444..479	CDD:293788	12/37 (32%)
		armadillo repeat	486..537	CDD:293788	6/50 (12%)
		Syo1_like	632..>740	CDD:240521	27/117 (23%)
		armadillo repeat	656..693	CDD:293788	10/36 (28%)
		ARM	703..738	CDD:214547	13/44 (30%)
		armadillo repeat	703..737	CDD:293788	11/38 (29%)
		armadillo repeat	793..829	CDD:293788	5/35 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910