DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc and Apc

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:XP_006525592.1 Gene:Apc / 11789 MGIID:88039 Length:2870 Species:Mus musculus


Alignment Length:2943 Identity:721/2943 - (24%)
Similarity:1056/2943 - (35%) Gaps:1050/2943 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 LDENPIPPDYML------------AQELREMREH-----RSLDRNFERQSAQQQQL--DELPPRN 160
            :|..|:..::.|            |:::|...|.     :.:::..:|:.|:.||:  |.|..|.
Mouse   177 IDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRVRQ 241

  Fly   161 GGGSPAS-AGRPSRSKE--PSYTLSRFLDGDAPA------------PAPRLPK------GAAWTT 204
            ...|.|: |.|.|:|:.  .|:...|..:|...|            ||.|:..      .::.|.
Mouse   242 LLQSQAAEAERSSQSRHDAASHEAGRQHEGHGVAESNTAASSSGQSPATRVDHETASVLSSSGTH 306

  Fly   205 SFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQ 269
            |...|.||.     ||:|||.|||||||||::|..:|::..|.:|.:..||.::|:|||:|||:|
Mouse   307 SAPRRLTSH-----LGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQ 366

  Fly   270 MMHAPDND----------QEVRKCAGQALHNVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTL 324
            ::|..|.|          :|.|..|..||||::||.||:|.||||.:||.||:||..||......
Mouse   367 LLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEW 431

  Fly   325 LQSGGEAIADDSDRHPL---------AAISSLMKVSFDEEHRHAMCEL----------------- 363
            .::..:.:  |.|::|:         .|:..|||:||||||||||.||                 
Mouse   432 QEAHEQGM--DQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGRKATRGISSQELGQGL 494

  Fly   364 -GALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQ 427
             |.|.||..|:.:|..::| ...|....:|||||.||||||||||..|||.||..|..|.|||||
Mouse   495 SGGLQAIAELLQVDCEMYG-LTNDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQ 558

  Fly   428 LDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSA 492
            |.|..:||.||.||||||||||||.|.|..|.|:|:|.||...|:..:.|:|||::|||||||||
Mouse   559 LKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSA 623

  Fly   493 HCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCL 557
            ||:.|||:.||||||||||||.|:|...:.||.|||:.|||||||||.||..|.:|||||::|||
Mouse   624 HCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL 688

  Fly   558 AILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALK 622
            ..|||.|||.|||:|||:||||||||||:.:||:.|||.|||.||::||||||.||:.||::||:
Mouse   689 QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALR 753

  Fly   623 NLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLD---------- 677
            ||:..|||...    |....|.| .:||:|..||.|||:.||..:|.:||.||:|          
Mouse   754 NLMANRPAKYK----DANIMSPG-SSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRS 813

  Fly   678 ----------------------------TG---------------------GKLD---------- 683
                                        ||                     |.||          
Mouse   814 KQRHKQNLYGDYAFDANRHDDSRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSL 878

  Fly   684 -KERASSSSRRHP------------------APRLTR-----SAMLTKSESRDSVYSAKSDCAYD 724
             :||....|..||                  |.::.:     ||:.|..:.|.|..:.:..|..|
Mouse   879 ERERGIGLSAYHPTTENAGTSSKRGLQITTTAAQIAKVMEEVSAIHTSQDDRSSASTTEFHCVAD 943

  Fly   725 --HLIRSASASDAHR---------------------------------------------KVKPK 742
              ...|.:|||..|.                                             ::||.
Mouse   944 DRSAARRSSASHTHSNTYNFTKSENSNRTCSMPYAKVEYKRSSNDSLNSVTSSDGYGKRGQMKPS 1008

  Fly   743 ITDFDLEME-----------------------QDTEATEEQPIDYSVKYSEN------------- 771
            :..:..:.|                       .|.:...:.||:||:|||:.             
Mouse  1009 VESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNE 1073

  Fly   772 ---------------------ATKTSTY------------------------------------- 778
                                 .::.::|                                     
Mouse  1074 RWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENTDDKHLKFQPHFGQQECVSPYRSRGTSGSET 1138

  Fly   779 ------------------QETDL--DQPTDFSLRYAENQ----------------------IESD 801
                              ||.|.  |:||::|.||:|.:                      ::..
Mouse  1139 NRMGSSHAINQNVNQSLCQEDDYEDDKPTNYSERYSEEEQHEEEEERPTNYSIKYNEEKHHVDQP 1203

  Fly   802 LDISGPAGGQKSTITPPAETVPEKSEGQEILLILDDSVK----CYQTEDTPYVISNAASVTDLRV 862
            :|.|.......|:...|:.:..:.|..|        |.|    ...:|:|....|||.....||.
Mouse  1204 IDYSLKYATDISSSQKPSFSFSKNSSAQ--------STKPEHLSPSSENTAVPPSNAKRQNQLRP 1260

  Fly   863 AAKADAEAEVKPEVREVTSKEGAPKKLPKLSQCGSGSYTPEKPINYCEEGTPGYFSRYDSLSSL- 926
            ::..          |...:::|...|:|.::|        |....||.|.||..|||..||||| 
Mouse  1261 SSAQ----------RNGQTQKGTTCKVPSINQ--------ETIQTYCVEDTPICFSRCSSLSSLS 1307

  Fly   927 ---DESGKANQAIVGTDADIKPKLEKQEEQESQPAEQVLTKPP---------------------- 966
               ||.|..........|:.....|.:|...::.||...|:.|                      
Mouse  1308 SADDEIGCDQTTQEADSANTLQTAEVKENDVTRSAEDPATEVPAVSQNARAKPSRLQASGLSSES 1372

  Fly   967 TQANSAL--------------------------ETPLMFSRRSSMDSLVHDPDVDVANCDDKSSV 1005
            |:.|.|:                          ||||:|||.:|:.||.......:|     |||
Mouse  1373 TRHNKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLVFSRCTSVSSLDSFESRSIA-----SSV 1432

  Fly  1006 VSD-FSRLASGVISPSEIPDSPTQSMPQSPRRNSVAGSGQNVDS----PPVVIPAS--------- 1056
            .|: .|.:.||:||||::||||.|:||.| |..:.....|.|.:    |...:||:         
Mouse  1433 QSEPCSGMVSGIISPSDLPDSPGQTMPPS-RSKTPPPPPQTVQAKREVPKSKVPAAEKRESGPKQ 1496

  Fly  1057 ---------LQPLRSVFEDDLSSFNVEHTPAQFSTATSLSNLSIVDDE---------KAPASVAE 1103
                     :|.|..|  |.|..|..|.||..||.::|||.||:  ||         :....|.|
Mouse  1497 TAVNAAVQRVQVLPDV--DTLLHFATESTPDGFSCSSSLSALSL--DEPFIQKDVELRIMPPVQE 1557

  Fly  1104 EDNEDELLLANCINMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDTPALLSKVPSNTNLSVI 1168
            .||.:|                         :|.:..||:     .|:....:.|..|..:|   
Mouse  1558 NDNGNE-------------------------TESEQPEES-----NENQDKEVEKPDSEKDL--- 1589

  Fly  1169 SMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGM-------KKPLGEATS 1226
                .|..|             .||:            .:|::||...|       .|.|.:..|
Mouse  1590 ----LDDSD-------------DDDI------------EILEECIISAMPTKSSRKAKKLAQTAS 1625

  Fly  1227 ---DPIAMLRRGGNELPGY-----------------LPSADEMNKFLVEDSPCNFSVVSGLSNLT 1271
               .|:|   |..::||.|                 .|..|....:.||.:|.|||..:.||:||
Mouse  1626 KLPPPVA---RKPSQLPVYKLLPAQNRLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLT 1687

  Fly  1272 VGSSLVGPAVQLKETEPSSAD-QNPEMKAKPGKQEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQA 1335
            :.|    |..:|...:...|. |:.|.:.:.....:.|.....|...:||:.....||.......
Mouse  1688 IES----PPNELATGDGVRAGIQSGEFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDDNKAEEGD 1748

  Fly  1336 IAAGCNRPKSNLGFSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSSDSN 1400
            |.|.|                          ||:|......:....|:|...|...:|..||.:|
Mouse  1749 ILAEC--------------------------INSAMPKGKSHKPFRVKKIMDQVQQASSTSSGAN 1787

  Fly  1401 DNQSKSLFELCILKGMYKTKEPGARAQQMQEQPIVGSSSVQSNPSLKQFDSLPVQLPSSGQVKRQ 1465
            .||..:           |.|:|              :|.|:..|...::                
Mouse  1788 KNQVDT-----------KKKKP--------------TSPVKPMPQNTEY---------------- 1811

  Fly  1466 RHHHHHHHHRERERERKDEKLLQECINTGISKKINAVPKNVLATSAAALEPCHPMAATTSASALS 1530
                       |.|.||         ||  ..|:|...:...:.:..:.:|    :..|:|.|.:
Mouse  1812 -----------RTRVRK---------NT--DSKVNVNTEETFSDNKDSKKP----SLQTNAKAFN 1850

  Fly  1531 TAAPDVEQK---AHATSNPQQQSSTHPSSHILPNPIDAIATVTDTVRSPAAPNQGNGNASQNGLE 1592
            ...|:.|.:   :.|..:|...:           ||:            ..|...:.|.|.:.|:
Mouse  1851 EKLPNNEDRVRGSFALDSPHHYT-----------PIE------------GTPYCFSRNDSLSSLD 1892

  Fly  1593 TATGSKDLDSED---RSSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKSVERLTME 1654
            ......||..|.   |...||.           ||....||       ..:|:            
Mouse  1893 FDDDDVDLSREKAELRKGKESK-----------DSEAKVTC-------RPEPN------------ 1927

  Fly  1655 FVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSFPSVSQTAPVLASLSLDEDATEARS 1719
                     ||....|.|.:...:.:|...::.......:||..|:..|...:      ||:.:.
Mouse  1928 ---------SSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSSKDGPDRGA------ATDEKL 1977

  Fly  1720 LHELIEITPTNEQQPESLE--GETDTLVNGHADSYSGSSGGLNFQLGGQVQNAGVRLEPQRLLFN 1782
            .:..||.||....:..||.  .:.|...|.:.:|          :...:.:.|..:.||.:...:
Mouse  1978 QNFAIENTPVCFSRNSSLSSLSDIDQENNNNKES----------EPIKEAEPANSQGEPSKPQAS 2032

  Fly  1783 G-TSASIMTNSTMIAFEARALAENLLQPAATDDDTTEMTFSLNSLDLDNIRPPSGMESLNSCYQD 1846
            | ...|.....|.:.|...:                    ||:||.:|: ......|.::|....
Mouse  2033 GYAPKSFHVEDTPVCFSRNS--------------------SLSSLSIDS-EDDLLQECISSAMPK 2076

  Fly  1847 HSQPSSLRQAMPSKSPRFARKMFPANLVARRALGHLAGSAESVNSSCNLLDNIKPPSLMDELLDS 1911
            ..:||.|:.....:|||                  ..|...:.:.:.:|.|..:|.|      :.
Mouse  2077 KKRPSRLKSESEKQSPR------------------KVGGILAEDLTLDLKDLQRPDS------EH 2117

  Fly  1912 MISVDSIQSEVADGEQDCSMATTISVSNYETAACDDQTMTVLQSCFDEDEDATMNDYSSAESTPK 1976
            ..|.|   ||..|.:.....|.:|..|.::.||.        .:|......:..:...|.:|...
Mouse  2118 AFSPD---SENFDWKAIQEGANSIVSSLHQAAAA--------AACLSRQASSDSDSILSLKSGIS 2171

  Fly  1977 HGS----TPSPNRRSLTPKDKRRLTKDRFKTYTIATSCEMEAPEANETLQIEIVEAAVPVATPSP 2037
            .||    ||....:..|.....|:.|                |....||:.:.:|:         
Mouse  2172 LGSPFHLTPDQEEKPFTSNKGPRILK----------------PGEKSTLEAKKIES--------- 2211

  Fly  2038 RANGRRRGSAERYKTQLI-------ECPLALIQPQPDDCPSEQLSSIRAMMQQFTFITDINIGHS 2095
             .|...:|..:.||:.:.       |....:.||.|.:.||  :|..|.|:.    |..:....|
Mouse  2212 -ENKGIKGGKKVYKSLITGKIRSNSEISSQMKQPLPTNMPS--ISRGRTMIH----IPGLRNSSS 2269

  Fly  2096 QETCESTDHP-----------------------EDAGE---SPECDQNSE--------------- 2119
            ..:..|...|                       :.||:   ||...|.|:               
Mouse  2270 STSPVSKKGPPLKTPASKSPSEGPGATTSPRGTKPAGKSELSPITRQTSQISGSNKGSSRSGSRD 2334

  Fly  2120 -TESCDGQEPDQLP-----------------PPPSIVDLRTSVVKPTTLEPATAVKLVRGRKKPA 2166
             |.|...|:|...|                 ||..:..|      |.|..|:||.....|..|.:
Mouse  2335 STPSRPTQQPLSRPMQSPGRNSISPGRNGISPPNKLSQL------PRTSSPSTASTKSSGSGKMS 2393

  Fly  2167 YVSPYSMQSQRN---------------------------SNNAAPSKKKTLSPTIAKRSLVPGGS 2204
            |.||....||:|                           ||....:||..||...:.:|     |
Mouse  2394 YTSPGRQLSQQNLTKQASLSKNASSIPRSESASKGLNQMSNGNGSNKKVELSRMSSTKS-----S 2453

  Fly  2205 GVRLPAKKKPTPPPEPAPARLERQGTFVK--------------------------DEPTNSNVQV 2243
            |......::|.         |.||.||:|                          |.||.|..|.
Mouse  2454 GSESDRSERPA---------LVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPDSPTRSQAQT 2509

  Fly  2244 PVVE-TKPAQTSPTHRA------SKLPTKKGTA---SGGSPSK--------AGSPKRIPLAPA-- 2288
            ||:. :.|..:..||.:      .|||......   :.|.|:|        :.||.|:|:..|  
Mouse  2510 PVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDGRPTKRHDIARSHSESPSRLPINRAGT 2574

  Fly  2289 -RRMTPQRANTSLRLAAGKSHAASRVVSGRVSSTTPPSRSNSNLNGSSAAAAAAAKINHAQSRIA 2352
             :|...:.:::..|::..:...:|..:....|.::..::|....:.||..|....|.|...::  
Mouse  2575 WKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDERHVSSMPAPRQMKENQVPTK-- 2637

  Fly  2353 NIWKRVDEAKTKQSSSNLRTQKTKSSNMLNANGTKPTLLR-----SSTFD--------------- 2397
            ..|:::.|:..  |.:.:.:| :.||...:...:||.:.:     |.|.|               
Mouse  2638 GTWRKIKESDI--SPTGMASQ-SASSGAASGAESKPLIYQMAPPVSKTEDVWVRIEDCPINNPRS 2699

  Fly  2398 ------NTPSTAGGVKSK 2409
                  |||.....|..|
Mouse  2700 GRSPTGNTPPVIDSVSEK 2717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 51/103 (50%)
armadillo repeat 258..332 CDD:293788 35/83 (42%)
ARM 332..448 CDD:237987 67/142 (47%)
armadillo repeat 369..403 CDD:293788 14/33 (42%)
armadillo repeat 411..448 CDD:293788 24/36 (67%)
armadillo repeat 498..539 CDD:293788 28/40 (70%)
ARM 506..624 CDD:237987 79/117 (68%)
armadillo repeat 548..582 CDD:293788 25/33 (76%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 7/26 (27%)
APC_crr 903..927 CDD:283553 14/27 (52%)
APC_crr 1066..1090 CDD:283553 11/23 (48%)
APC_crr 1247..1271 CDD:283553 9/23 (39%)
ApcXP_006525592.1 Suppressor_APC 135..215 CDD:371516 9/54 (17%)
ARM 348..400 CDD:214547 22/51 (43%)
APC_rep 401..474 CDD:376216 41/99 (41%)
armadillo repeat 498..534 CDD:293788 22/35 (63%)
ARM 538..579 CDD:214547 31/40 (78%)
armadillo repeat 542..579 CDD:293788 29/36 (81%)
armadillo repeat 589..621 CDD:293788 22/31 (71%)
armadillo repeat 629..670 CDD:293788 28/40 (70%)
ARM 675..715 CDD:214547 15/39 (38%)
armadillo repeat 679..713 CDD:293788 12/33 (36%)
Arm 717..755 CDD:366143 21/107 (20%)
armadillo repeat 721..757 CDD:293788 18/105 (17%)
Arm_APC_u3 758..1045 CDD:374686 89/530 (17%)
APC_u5 1062..1161 CDD:374687 43/130 (33%)
APC_r 1283..>1300 CDD:368672 5/19 (26%)
APC_u9 1309..1395 CDD:374689 23/86 (27%)
APC_r 1663..1686 CDD:368672 4/25 (16%)
APC_u13 1688..1741 CDD:374690 7/52 (13%)
SAMP 1742..1763 CDD:368673 4/20 (20%)
APC_u14 1772..1865 CDD:374691 18/95 (19%)
APC_u15 1899..1973 CDD:374692 13/73 (18%)
SAMP 2060..2079 CDD:368673 2/18 (11%)
APC_basic 2251..2596 CDD:368684 59/294 (20%)
EB1_binding 2698..2870 CDD:368678


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837312
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2122
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 548 1.000 Inparanoid score I1140
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm8887
orthoMCL 1 0.900 - - OOG6_105450
Panther 1 1.100 - - O PTHR12607
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.840

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