DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc and APC2

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:XP_006722671.2 Gene:APC2 / 10297 HGNCID:24036 Length:2404 Species:Homo sapiens


Alignment Length:2478 Identity:636/2478 - (25%)
Similarity:925/2478 - (37%) Gaps:651/2478 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 AQELREMREHR--SLDRNFERQSAQQQQLDELPPRNGGGSPASAGRPSRSKEPSYTL---SRFLD 186
            ||.:|.:.|.|  :.|...:|...:..:|:::..     ....|....:..||...|   |..:|
Human   292 AQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDK-----ELLEAQDRVQQTEPQALLAVKSVPVD 351

  Fly   187 GDAPAPAPRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGN 251
            .|.....|..|:              ........||||.|:.|||||.:.|..:.|:..|.:|.:
Human   352 EDPETEVPTHPE--------------DGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSS 402

  Fly   252 AQSCATLRRSGCMPLLVQMMHAPD-------------NDQEVRKCAGQALHNVVHSHPDEKAGRR 303
            .:||..:|||||:|||:|::|..:             ..::.|..|..||||:|.|.||:...|:
Human   403 PESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPDQGLARK 467

  Fly   304 EAKVLRLLDQIVDYCSFLKTLLQS------GGEAIADDSDRHP--LAAISSLMKVSFDEEHRHAM 360
            |.:||.:|:||..||......||:      ||.|.:......|  ..|..::||:|||||:|.||
Human   468 EMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMKLSFDEEYRRAM 532

  Fly   361 CELGALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALV 425
            .|||.|.|:..|:.:|:.:| ....|....:|||||.|.||||||||..|||.||.::..|||:|
Human   533 NELGGLQAVAELLQVDYEMH-KMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIV 596

  Fly   426 AQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNL 490
            |||.|..::|.||.:|:|||||||||.|.|.||.|.|:||||....:|...|:|||::|||||||
Human   597 AQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWNL 661

  Fly   491 SAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHN 555
            |||.:.|||..|.|||||.|||..|:|:..|.:|.|||:.|||||||||.:|..|.|||:||.||
Human   662 SAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLVATREDYRQVLRDHN 726

  Fly   556 CLAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSA 620
            ||..|||.|.|.|||:|||:||||||||||||.||:.|||.|||.|||:|:||||.||:.||::|
Human   727 CLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAA 791

  Fly   621 LKNLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLDTGGKLDKE 685
            |:|||..|||   .||....|.|.| ..:|:|..||.:||:.||..||.|:..::|:..|    .
Human   792 LRNLLAHRPA---KHQAAATAVSPG-SCVPSLYVRKQRALEAELDARHLAQALEHLEKQG----P 848

  Fly   686 RASSSSRRHPAPRLTRSAMLTKSESRDSVYSAKSDCAYDHLIRS--ASASDAHRKVKPKITDFDL 748
            .|:.::.:.|.|.|.....|.:.      |::.|.|..|....|  |:|:.......|......|
Human   849 PAAEAATKKPLPPLRHLDGLAQD------YASDSGCFDDDDAPSSLAAAAATGEPASPAALSLFL 907

  Fly   749 ---------------------EMEQDTE------ATEEQPIDYSVKYSENATKTSTYQETDLDQP 786
                                 |.|:||.      |..:..:..:|...:...:..:...|..|. 
Human   908 GSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDD- 971

  Fly   787 TDFSLRYA--------ENQIESDLDISGPAGGQK----------------STITPPAETVPEKSE 827
             .|||...        |.:.:|.....||.||::                ::::..:......|:
Human   972 -SFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHASLSNDSLNSGSASD 1035

  Fly   828 G---QEILLILDDSVKCYQTEDTPYVISNAASVTDL-----------RVAAKADAEA---EVKPE 875
            |   :|.:|....:....:.|| |.......|..||           |.|..|||..   ::.|.
Human  1036 GYCPREHMLPCPLAALASRRED-PRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPT 1099

  Fly   876 VREVTSKEGA------PKKLPKLSQCGSG----------SYTPEK----PINY---------CEE 911
            .:.|...|||      |...|.:|. |:.          |..|||    |::.         .:|
Human  1100 YQHVPLLEGASRAGAEPLAGPGISP-GARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQE 1163

  Fly   912 GTPGYFSRYDSLSSLDESGKANQAIVGTDADIKPKLEKQEEQESQPAE----------------- 959
            | |...||..|||||..:|:...:..|...|....||..||.....||                 
Human  1164 G-PLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAI 1227

  Fly   960 -------------QVLTKPPTQANSALETPLMFSRRSSMDSLVHDPDVDVANCDDKSSVVSD-FS 1010
                         :..|...:..|...||||:.||.||:.||.......:|     ||:.|: .|
Human  1228 PAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIA-----SSIPSEPCS 1287

  Fly  1011 RLASGVISPSEIPDSPTQSMPQSPRRNSVAGSGQNVDSPPVVIPASLQ----------------P 1059
            ...||.|||||:||||.|:||  |.|:...........||.....|||                .
Human  1288 GQGSGTISPSELPDSPGQTMP--PSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRER 1350

  Fly  1060 LRSVFEDDLSS--FNVEHTPAQFSTATSLSNLSIVDDEKAPASVAEEDNEDELLLANCINMG--- 1119
            .|...|.|..|  |.||.....||.|:|||.|::.:      ...::|.|..||.:.|...|   
Human  1351 CRLPSELDAGSVRFTVEKPDENFSCASSLSALALHE------HYVQQDVELRLLPSACPERGGGA 1409

  Fly  1120 ----------MQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDTPALLSK-----VPSNTNLSV-I 1168
                      .:|:...|...:......|...|.:|.......||.|.|     ||....|.| :
Human  1410 GGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPV 1474

  Fly  1169 SMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRD------GMKKPLGEATSD 1227
            .|....|..|   |........::....|.|.....|...||...||      |.::|.|..||.
Human  1475 YMLVPAPAPA---QEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSA 1536

  Fly  1228 PIAMLRRGGNELPGYLPSADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLVGPAVQLKETEPSSAD 1292
            ..||..|  ::..|...||::                    :...|.:..|..:.|.....:.||
Human  1537 RQAMGHR--HKAGGAGRSAEQ--------------------SRGAGKNRAGLELPLGRPPSAPAD 1579

  Fly  1293 QNPEMKAKPGKQEQVRRPPHWQDDSLSSLSI--------------DSEDD--------TNLLSQA 1335
            ::   .:|||:..        .|.:|.||.:              ||:::        |:..:.|
Human  1580 KD---GSKPGRTR--------GDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSA 1633

  Fly  1336 I--AAGCNRPKSNLGFSSNGK-----------RSSSLSSSQPIAINAATSASSLN----SAMTVR 1383
            |  |....||:......:..|           :.|.::...|...:.::|||||:    |.....
Human  1634 IPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAV 1698

  Fly  1384 KSQQQESYSSVD-------SSDSNDNQSKSLFELCILKGMYKTKEPGA-------RAQQMQEQPI 1434
            ..:.:|...:.|       .|..:...::.|.:.||...:.:.:.|.:       ||.::.|:|.
Human  1699 HPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPA 1763

  Fly  1435 VGSSSVQSNPSLKQFDSLPVQLPSSGQVKRQRHHHHHHHHRERERERKDEKLLQECINTGISKKI 1499
            .||                          |:|........|..:.:..:.:.:||    |.:..:
Human  1764 EGS--------------------------RERGEEAAGSDRASDLDSVEWRAIQE----GANSIV 1798

  Fly  1500 NAVPKNVLATSAAALEPCHPMAATTSASALSTAAPDVEQKAHATSNPQQQSSTHPSSHILPNPID 1564
            ..:.:...||..|:.|....::..:..|..||..|...:|.       :|:.....|...|....
Human  1799 TWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKG-------RQAEGEMGSARRPEKRG 1856

  Fly  1565 AIATVTD-TVRSPAAPNQGNGNASQN-GLETATGSKDLDSEDRSSDESNQSFIMETMVRLDSALN 1627
            |.:..|. :.||||.|.:..|..... |:......:                   |::.:.|...
Human  1857 AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGR-------------------TVIYVPSPAP 1902

  Fly  1628 ETCISG-----ASEKHKDPDLMLKSVERLTMEFVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNES 1687
            .....|     |:.:...|..:.:......   |.|..|.||.|.:..:..|....         
Human  1903 RAQPKGTPGPRATPRKVAPPCLAQPAAPAK---VPSPGQQRSRSLHRPAKTSELAT--------- 1955

  Fly  1688 TCPNDVSFPSVSQTAPVLASLSLDEDATEARSLHELIEITPTNEQQPESLEGETDTLVNGHADSY 1752
                 :|.|..|.|.|  |.|:....::.:::       :|.::..|......|           
Human  1956 -----LSQPPRSATPP--ARLAKTPSSSSSQT-------SPASQPLPRKRPPVT----------- 1995

  Fly  1753 SGSSGGLNFQLGGQVQNAGVRLEPQRLLFNGTSASIMTNSTMIAFEARALAENLLQPAATDDDTT 1817
                     |..|.:...|....|:.                   .||.|   |.:...|.....
Human  1996 ---------QAAGALPGPGASPVPKT-------------------PARTL---LAKQHKTQRSPV 2029

  Fly  1818 EMTFSLNSLDLDNIRPPSGMESLNSCYQDHSQPSSLRQAMPSKSPRFARKMFPANLVAR------ 1876
            .:.|         ::.|:           ...|..|.:|:|...|| .|....|...||      
Human  2030 RIPF---------MQRPA-----------RRGPPPLARAVPEPGPR-GRAGTEAGPGARGGRLGL 2073

  Fly  1877 -RALGHLAGSAESVNSS--CNLLDNIK-PPSLMDELLDSMISVDSIQSEVADGEQDCSMATTISV 1937
             |....|:..:||.:.|  ...|..|| .|.|...           :||::..|           
Human  2074 VRVASALSSGSESSDRSGFRRQLTFIKESPGLRRR-----------RSELSSAE----------- 2116

  Fly  1938 SNYETAACDDQTMTVLQSCFDEDEDATMNDYSSAESTPKHGSTPSPNRRSLTPKDKRRLTKDRFK 2002
                                            ||.|.|: |::|...|.:|.            .
Human  2117 --------------------------------SAASAPQ-GASPRRGRPALP------------A 2136

  Fly  2003 TYTIATSCE--MEAPEANETLQIEIVEAAVPVATPSPRANGRRRGSAERYKTQLIECPLALIQPQ 2065
            .:..::.||  ..||.....    ......|.|.|||.....||.::|......:..|.|    :
Human  2137 VFLCSSRCEELRAAPRQGPA----PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAA----R 2193

  Fly  2066 PDDCPSEQLSSIRAMMQQFTFITDINIGHSQETCESTDHPEDAGESPECDQNSETESCDGQEPDQ 2130
            |:            .::::..:..|::..         .|:.|..:.....::...|.|| ||..
Human  2194 PE------------TVKRYASLPHISVAR---------RPDGAVPAAPASADAARRSSDG-EPRP 2236

  Fly  2131 LPPPPS-------IVDLRTSVVKPTTLEPATAVKLVRGRKKPAYVSPYSMQSQ----RNSNNAAP 2184
            ||...:       |.|.....:..:|| ||||:.|.....:.|...|...::.    :....|||
Human  2237 LPRVAAPGTTWRRIRDEDVPHILRSTL-PATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAP 2300

  Fly  2185 SKKKTLSPTIAKRSLVPGGSGVRLPAKKKPTPPPEPAPARLERQGTFVKDEPTNSNVQVPVVETK 2249
            ....:.||::..|.                 ||..||..:|...|         |:|..|.:...
Human  2301 KTNSSTSPSLETRE-----------------PPGAPAGGQLSLLG---------SDVDGPSLAKA 2339

  Fly  2250 PAQTSPTHRASKLPTKKGTASGGSP-SKAGSPKRIPLAPARRMTPQRANTSLRLAAGKSHAASRV 2313
            |......|..      .|.|.||.| |:.|||.|....|.....|     |..:.|..:.:|:..
Human  2340 PISAPFVHEG------LGVAVGGFPASRHGSPSRSARVPPFNYVP-----SPMVVAATTDSAAEK 2393

  Fly  2314 VSGRVSST 2321
            .....|:|
Human  2394 APATASAT 2401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 42/106 (40%)
armadillo repeat 258..332 CDD:293788 33/92 (36%)
ARM 332..448 CDD:237987 56/117 (48%)
armadillo repeat 369..403 CDD:293788 12/33 (36%)
armadillo repeat 411..448 CDD:293788 20/36 (56%)
armadillo repeat 498..539 CDD:293788 25/40 (63%)
ARM 506..624 CDD:237987 78/117 (67%)
armadillo repeat 548..582 CDD:293788 24/33 (73%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 4/22 (18%)
APC_crr 903..927 CDD:283553 12/36 (33%)
APC_crr 1066..1090 CDD:283553 11/25 (44%)
APC_crr 1247..1271 CDD:283553 0/23 (0%)
APC2XP_006722671.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147382
Domainoid 1 1.000 191 1.000 Domainoid score I3246
eggNOG 1 0.900 - - E1_KOG2122
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 626 1.000 Inparanoid score I865
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm8653
orthoMCL 1 0.900 - - OOG6_105450
Panther 1 1.100 - - LDO PTHR12607
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.790

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