DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Apc and ankar

DIOPT Version :9

Sequence 1:	NP_001263046.1	Gene:	Apc / 44642	FlyBaseID:	FBgn0015589	Length:	2417	Species:	Drosophila melanogaster
Sequence 2:	XP_031749763.1	Gene:	ankar / 100496722	XenbaseID:	XB-GENE-1010351	Length:	1400	Species:	Xenopus tropicalis

Alignment Length:	788	Identity:	149/788 - (18%)
Similarity:	284/788 - (36%)	Gaps:	252/788 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 EMAKKFLELSGNAQSCATLR-------RSGCMPLLVQMMHAPDNDQEVRKC-AGQALHNVVHSHP 296
            |||.:.||:     .|...|       ::|.:|.||:::|   :||...|| |...|.|:.:::|
Frog   737 EMAVRCLEV-----LCVVNRNYWEDIYKAGTIPSLVELLH---SDQVPLKCLALGILSNISNNNP 793

  Fly   297 DEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDSDRHPLAAISSLMKVSFDEEHRHAMC 361
            ..:|                       |::||
Frog   794 VSRA-----------------------LVKSG--------------------------------- 802

  Fly   362 ELGALHAIPNLVHLDHAVHGPKPEDQC-CNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALV 425
                  ||..||||   :|..:||.|. |:.|       |:::...|.|...:  .:...:..||
Frog   803 ------AIQVLVHL---LHSRQPELQSRCSVL-------LSDIAQIDSNQNVI--AEMDGISPLV 849

  Fly   426 AQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNL 490
            ..|....:|:|....:.:|.|..:..:|.||| .::|.:.:| :..:..:|:..:.|....:..|
Frog   850 HLLYEKYEDVLVNAVNCIRVLCIKNTANQKAV-RDLGAIPSL-VEFLTAKSDILVSAATDVIAEL 912

  Fly   491 SAHCSTNKAEFCAV--DGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHI-------AVCEP 546
            :   ..|||...||  :|.:..|:.:|.                 :||::..:       |:|:.
Frog   913 A---RDNKAIQDAVTKEGVIESLISILR-----------------VRNINIQVKAAMTIEALCDH 957

  Fly   547 YRQILRQHNCLAI---LLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDN------------ 596
            ...:.::....::   :.:.||...|.|......|||.|:.::.:.||.:.:.
Frog   958 NPAVQKEFLTKSVTKHISKLLKVFQLEVREQGSTTLWALAGQTRKQQKAMAEYIGYKCIIDMLLS 1022

  Fly   597 --------GAVPMLRSLIHSKH--AMISEGSS-SALKNLLNFRPAVQNHHQLDPIARSMGLKALP 650
                    |...::.....|:|  ..|.||:. ..|..||. .|.|.| ..|..|.:::|:..:.
Frog  1023 PSDKMQYIGGEAIIALCKDSRHYQCQICEGNGIGPLVRLLR-SPKVAN-GTLIRIIKALGIMCIG 1085

  Fly   651 TLEARKAKALQQELGERHTAETCDNLDTGGKLDKERASSSSRRHPAPRLTRSAMLTKSESRDSVY 715
            ........| |:::.|.:...|..:|                     ..|::::..|:|     .
Frog  1086 VAFINNPVA-QEKIVEENAIPTLLHL---------------------LKTQNSLHVKAE-----V 1123

  Fly   716 SAKSDCAYDHLIRSASASDAHRKVKP-KITD-FDLEMEQDTEATEEQPIDYSVKYSENA-TKTST 777
            :....|.   ::|:::..|:.::::. |.:| .||....|      :.|.....|:.:. ..:||
Frog  1124 ACTLACI---VLRNSNLQDSLKEMEDVKYSDILDLLYASD------KAICLRAGYALSLFAYSST 1179

  Fly   778 YQETDLDQPTDFSLRYAENQIESDLDISGPAGGQKSTITPP---AETVPEKSEGQEILLIL---- 835
            .|:.::          .||            ||.|.:|..|   ::..||::.....:::|
Frog  1180 MQQFNI----------LEN------------GGIKISIYEPFLQSDIEPERALAAFQIVVLAKVI 1222

  Fly   836 ---DDSVKCYQTEDTPYVISNAASVTDLRVAAKADAE-AEVKPEVREVTSKEGAPKKLPKLSQCG 896
               |....|.:.......:..:.:.|.|.:..:..|. |.::..:.|..:..|..|.|     |
Frog  1223 SDMDQITLCTKGVTVLTELLQSKNPTTLVLTGELLATLAHIRTGIPEAITTLGTVKCL-----C- 1281

  Fly   897 SGSYTPEKPINYCEEGTPGY--FSRYDS-----------------LSSLDESGKANQAIVGTDAD 942
            :..|:|::.:........||  |:|..|                 :|:|.|..:.::..  ||
Frog  1282 NHLYSPDEEVRIACANALGYLTFNRTASRHLLAECRTRPCLYNLLISNLSEDARMSKTF--TD-- 1342

  Fly   943 IKPKLEKQ 950
             :.|::||
Frog  1343 -EFKIQKQ 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc	NP_001263046.1	ARM	222..316	CDD:237987	21/83 (25%)
		armadillo repeat	258..332	CDD:293788	18/81 (22%)
		ARM	332..448	CDD:237987	22/116 (19%)
		armadillo repeat	369..403	CDD:293788	12/34 (35%)
		armadillo repeat	411..448	CDD:293788	7/36 (19%)
		armadillo repeat	498..539	CDD:293788	9/42 (21%)
		ARM	506..624	CDD:237987	24/150 (16%)
		armadillo repeat	548..582	CDD:293788	7/36 (19%)
		armadillo repeat	590..624	CDD:293788	9/56 (16%)
		APC_crr	837..860	CDD:283553	2/22 (9%)
		APC_crr	903..927	CDD:283553	6/42 (14%)
		APC_crr	1066..1090	CDD:283553
		APC_crr	1247..1271	CDD:283553
ankar	XP_031749763.1	ANKYR	<530..641	CDD:223738
		ANK repeat	537..586	CDD:293786
		Ank_2	593..688	CDD:403870
		ANK repeat	621..655	CDD:293786
		ANK repeat	657..688	CDD:293786
		PLN03200	<722..>1011	CDD:215629	77/377 (20%)
		armadillo repeat	722..746	CDD:293788	5/13 (38%)
		armadillo repeat	756..788	CDD:293788	11/34 (32%)
		armadillo repeat	796..831	CDD:293788	17/106 (16%)
		armadillo repeat	836..870	CDD:293788	6/35 (17%)
		armadillo repeat	878..912	CDD:293788	7/35 (20%)
		armadillo repeat	920..954	CDD:293788	7/50 (14%)
		armadillo repeat	962..996	CDD:293788	7/33 (21%)
		armadillo repeat	1014..1038	CDD:293788	1/23 (4%)
		armadillo repeat	1046..1084	CDD:293788	12/39 (31%)
		armadillo repeat	1095..1130	CDD:293788	7/60 (12%)
		armadillo repeat	1185..1218	CDD:293788	9/54 (17%)
		armadillo repeat	1235..1260	CDD:293788	3/24 (13%)
		armadillo repeat	1268..1304	CDD:293788	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910