DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc and apc2

DIOPT Version :9

Sequence 1:NP_001263046.1 Gene:Apc / 44642 FlyBaseID:FBgn0015589 Length:2417 Species:Drosophila melanogaster
Sequence 2:XP_002941166.2 Gene:apc2 / 100487473 XenbaseID:XB-GENE-995291 Length:2325 Species:Xenopus tropicalis


Alignment Length:2760 Identity:664/2760 - (24%)
Similarity:1042/2760 - (37%) Gaps:865/2760 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LTPDLEEGIAELSLEDVDVDSVPERKPHF---LDYDAVPPPDYEEGFGASSGEQLKMDKKYERD- 66
            |..:|::..::|:..:.|...:.|...|.   |::|.        |.||...|.|...|..:.| 
 Frog    33 LRRELKDNSSQLNRLEHDTSDMKEVLKHLQVKLEHDV--------GGGAGHAEMLDQFKGLQGDI 89

  Fly    67 -GEVSDYELAASG-----------YTKKEFTQDDNTLHFTQSAV----GLGSGAVGKKPAAKHF- 114
             |..:.|...|.|           ..:|....:..|.......:    .|..|.:.|:...|.: 
 Frog    90 PGLYNLYTSPAIGPDISATPMQLEIPQKRARDESRTSELLMQELEKERSLLLGEIDKEEKEKLWY 154

  Fly   115 ----------LDENPIPPDYMLAQEL-REMRE------HRSLDRNFER-----QSAQ-------- 149
                      |:|.|....:.|..:| |:..|      |..|:..|..     |.||        
 Frog   155 YSQIQSLSKRLEELPHAETFSLQIDLIRQQLEFESDHLHCVLEERFGTADEMVQRAQIRASHLEQ 219

  Fly   150 -QQQLDELPPRNGGGSPASAGRPSRSKEPSYTLSRFLDGDAPAPAPRLPKGAAWTTSFDERYTSS 213
             :|||:|:..:       ........:|.|..|:..::.:|.||.             |:   ||
 Frog   220 IEQQLEEMQSK-------EVKEHQVIEEKSMDLAEKINTEAVAPP-------------DD---SS 261

  Fly   214 AVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPDND- 277
            ..:.   ||||.|:.|||||.:.|..:|::..|.:|.:..||..:|||||:|||:|::|..:.| 
 Frog   262 GQQE---SKVEVVFWLLSMLANRDKDDMSRTLLAMSSSQDSCQAMRRSGCLPLLIQILHEAERDT 323

  Fly   278 --------QEVRKCAGQALHNVVHSHPDEKAGRREAKVLRLLDQIVDY----CSFLKTLLQSGGE 330
                    ::.|..|..|||||:.|.|||...::|.:||.:|:||..|    |.:   :|:.  |
 Frog   324 KAPESSAFKDARMRANAALHNVIFSQPDEGQAKKEMRVLHILEQIRSYTETCCDW---MLEH--E 383

  Fly   331 AIADDSDRHPL-------AAISSLMKVSFDEEHRHAMCELGALHAIPNLVHLDHAVHGPKPEDQC 388
            .:.:..:.:|:       .|..::||:|||||:|.||.|||.|.||..|:.:|:.:: ....|..
 Frog   384 RVGNMHECNPVPVEPQICQASCAIMKLSFDEEYRRAMNELGGLQAIAELLEVDYLMN-RMTSDPL 447

  Fly   389 CNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSN 453
            ..:|||||.||||||||||..|||.||.::..|:|:||.|.|..::|.||.:|:|||||||||.|
 Frog   448 SLALRRYAGMALTNLTFGDVVNKATLCSRRGCMQAIVAHLASENEELQQVASSILRNLSWRADIN 512

  Fly   454 MKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYE 518
            .|.:|.|:|:|.:|...|:|...|:|||::||||||||||.:.|||..|:|:|:|.|||..|:|:
 Frog   513 SKKILREVGSVISLMQCALRANKESTLKSVLSALWNLSAHSTENKASVCSVEGSLGFLVSTLTYK 577

  Fly   519 GPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLS 583
            ..|.:|.|||:.|||||||||.||..:.||||||.||||..|||.|:|.|||:|||:||||||||
 Frog   578 CQSNSLSIIESGGGILRNVSSLIATRDDYRQILRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLS 642

  Fly   584 ARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKA 648
            ||.|:||:.|||.||:.|||:||||||.||:.||::||:|||..||....    |....|.| ..
 Frog   643 ARCAQDQELLWDLGAISMLRNLIHSKHKMIAMGSAAALRNLLAHRPVKYK----DASVISPG-SC 702

  Fly   649 LPTLEARKAKALQQELGERHTAETCDNLDTGGKLDKERASSSSRRHPAPRLTRSAMLTKSESRDS 713
            :|:|..||.|||:.||..:|.|||         :||:...|...:.|         |...||...
 Frog   703 MPSLYMRKQKALEAELDAKHLAET---------IDKQGLKSQPVKGP---------LRHIESLVK 749

  Fly   714 VYSAKSDCAYDHLI--RSASASDAHRKVKPKITDFDLEMEQDTEATEEQPIDYSVKYSENATKTS 776
            .|::.|.|..|..|  .|.||...:..|        |.|..::..|:.|.|              
 Frog   750 DYASDSGCFDDDDIPNTSISAETGNSSV--------LSMYLNSSYTQGQNI-------------- 792

  Fly   777 TYQETDLDQPTDFSLRYAENQIESDLDISGPAGGQKSTITPP------AETVPEK--SEGQEILL 833
                     |...||:.| .::|.       ....|:.|..|      |:.:|.|  |...:|..
 Frog   793 ---------PRTGSLKRA-GELEK-------VDSCKNEIRKPHEYISSADKLPTKIPSAISKIDR 840

  Fly   834 ILDDSVKCYQTEDTPYVISNAASVTDLRVAAKADAEAEVKPEVREVTSKEGAPKKLPKLS----- 893
            :::|....:.:.|..:.:|:.....|....:         .|:.|..:...:|.:|...|     
 Frog   841 LVEDVSTMHTSSDDSFSLSSEDHCIDWPCGS---------DELHEARAHSCSPCRLSDKSGLLRR 896

  Fly   894 ----------------------QCGSGS----YTPEKPINYCEEGTPGYFSRYDSLSSLDESGKA 932
                                  ...|||    |.|::.:..|            |.|||      
 Frog   897 DNISRAQALLRLKTAYTSLSNDSLNSGSTSDGYCPKEHMKPC------------SRSSL------ 943

  Fly   933 NQAIVGTDADIKPKLEKQEEQESQ-PAEQVLTKPPTQANSAL-ETPLMFSRRSSMDSLVHDPDVD 995
                    .|.|.:|::.:::.|: ..:.||...|.:.:||: :.|....:|...||.  ...|.
 Frog   944 --------IDYKDELQRYQKRPSRLDLKSVLVPKPERNDSAIKKVPSTEDQRQLYDST--SKSVS 998

  Fly   996 VANCDDKSSVVSDFSRLASGVISPSEIPDSP-TQSMPQSPRRNSVAGSGQNVDSPPVVIPAS-LQ 1058
            :.:..:|......|.:..|     :.:|..| ..::..||....:.|. .:|.|.....|.| ||
 Frog   999 LTSLKNKEGTEDHFVKSTS-----NTLPADPLVHTIKLSPSYKHITGL-DSVSSNVSGFPGSVLQ 1057

  Fly  1059 PLRS-------------VFE----------DDLSSFNVEHTPAQFSTATSLSNLS----IVDDEK 1096
            ..:|             .||          :.|..:.||.||..||..:|||:||    |:|.:.
 Frog  1058 QKKSWLLTSQIPDSYIKTFEKASNHSSTEQESLQKYAVEGTPICFSRCSSLSSLSSGDNILDGQS 1122

  Fly  1097 APASVAEEDNEDELLLANCINMGMQRKPTE--AVKSTVVNS-------------------EV--- 1137
            ...:..:.|:..|:|.....|:..:...||  |||..:|:|                   ||   
 Frog  1123 RSDNDIDSDSSLEILEMEEGNIKYKSNETEDAAVKQGIVSSVTSQPMVIPMPKPEKHFFREVSPS 1187

  Fly  1138 ---DVAEETIRSYCTEDTPALLSKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVS-SNA 1198
               |:...:......::||.::|:..|.::|.    |...|..|::.|:...:..:|..:| |..
 Frog  1188 RNDDMTPSSSSENYIQETPLVMSRCSSVSSLG----SFESPSIASSIQSDPCSEMISGTISPSEL 1248

  Fly  1199 SDCGG--------------ASGHLLQQCIR------DGMKKPLGEATSDPIAMLRRGGNELPGY- 1242
            .|..|              .||||.::..:      :.:||.:                |:..: 
 Frog  1249 PDSPGQTMPPSRSKTPSFETSGHLERETSQFNIQWENNVKKFM----------------EITDFK 1297

  Fly  1243 ----LP-SADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLVGPAVQLKETEPSSADQNPEMKAKPG 1302
                :| ..|.|..|.||....|||..|.||.|.:....:...|:||...|.| |:|        
 Frog  1298 ERFQIPRDIDSMIYFTVEKPTENFSCASSLSALPLHEHYIEKDVELKLIPPFS-DKN-------- 1353

  Fly  1303 KQEQVRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCNRPKSNLGFSSNGKRSSSLSSSQPIAI 1367
                                                 |      |.|.::.||..:         
 Frog  1354 -------------------------------------C------LNFVAHEKRGEN--------- 1366

  Fly  1368 NAATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQSKSLFELCILKGMYKTKEPGARAQQMQEQ 1432
                                                                          :|:
 Frog  1367 --------------------------------------------------------------REE 1369

  Fly  1433 PIVGSSSVQSNPSLKQFDSLPVQLPSSGQVKRQRHHHHHHHHRERERERKDEKLLQECINTGISK 1497
            .|:|..: :|...|...|                                |..:|:||||:.:..
 Frog  1370 RILGMMT-KSELELVSDD--------------------------------DIDILKECINSAMPS 1401

  Fly  1498 KINAVPKNVLAT---SAAALEPCHPMAATTSASALSTAAPDVEQKAHATSNPQQQSSTH-PSSHI 1558
            ::..|..:||:|   ::::.:|.|........:....|.|.|   .|:..:..:..|:: .|:..
 Frog  1402 RLRNVKTSVLSTHILNSSSKKPVHLPVYMLVPAHTQLAGPKV---FHSKQDLLKDDSSYTDSAEG 1463

  Fly  1559 LPNPIDAIATVTD-TVRSPAAPNQGNGNASQNGLETATGSKDLDSEDR-SSDESNQSFIMETMVR 1621
            .|....:.|:::| |::.|...:|                   |.:|| .|.:..:.|  .||  
 Frog  1464 TPVNFSSAASLSDETLQYPLKDDQ-------------------DLKDRLKSQKEKREF--GTM-- 1505

  Fly  1622 LDSALNETCISGASEKHKDPDLMLKSVERLTMEFVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNE 1686
            |||.|         ||.:      :|:  .|||.:...|::|.   |...:|..|.::..|.   
 Frog  1506 LDSNL---------EKKR------RSI--YTMENIADNEEMRK---NFYCANPTKYSNKGNR--- 1547

  Fly  1687 STCPNDVSFP-SVSQTAPVLASLSLDEDAT---EARSLHELIEITPTNEQQPESLEGETDTLVNG 1747
               |...::| ...||    .::...|..|   :||:.     ::|.:..:.:..:||   .|:|
 Frog  1548 ---PTSPAYPLKAHQT----TTIGGPEHGTVKYDARTF-----VSPGHPSKLDLNQGE---YVHG 1597

  Fly  1748 HADSYSGSSGGLNFQLGGQVQNAGVRLEPQRLLFNGTSASIMTNSTMIAFEARALAENLLQPAAT 1812
            :                                              :||          |....
 Frog  1598 N----------------------------------------------LAF----------QSFCH 1606

  Fly  1813 DDDTTEMTFSLNSLDLDNIRPPSGMESLNSCYQDHSQPSSLRQAMPSKSPRFARKMFPANLVARR 1877
            ...|.|..:.....|.|.:            |.:.:.|...::  |:||||  :.::..  |::|
 Frog  1607 TTPTEEAVYCFYEEDRDTL------------YSNKNSPKIKQE--PTKSPR--KSLYTG--VSKR 1653

  Fly  1878 ALGHLAGSAES--VNSSCNLLDNIKPPSLMDELLDSMISVDSIQSEVADGEQDCSMATTISVSNY 1940
            ....|..|..|  .::..||:::...|         ..|:.|..|.::|.|..|:: ..:..|..
 Frog  1654 GTNGLPASKSSNYASTFSNLIEDEPIP---------CYSLSSSMSSLSDIEPICAL-EKVDKSRR 1708

  Fly  1941 ETAACDDQTMTVLQSCFDEDEDATMNDYSSAESTPKHGSTPSPNRRSLTPKDKRRLTKDRFKTYT 2005
            .:|....:::.:         .|...|.|.:.::.:...|     .|:.|:.||...:.|..|..
 Frog  1709 HSARLQCRSLNI---------HAGSRDSSVSRTSDEERCT-----SSVLPRRKRTSARKRKHTLK 1759

  Fly  2006 IATSCEME------APEANETLQIE------IVEAAVPV--------ATPSPRANGRRRGSAERY 2050
            :..|...:      :|:..|...::      |.|.|..:        ::.|...:...||.:   
 Frog  1760 LTQSKSEQNPVGDRSPDGGEMSDLDSIDWEAIKEGANSIVSWIHQAASSISRSTSSMSRGPS--- 1821

  Fly  2051 KTQLIECP-LALIQPQPDDCPSEQLSSIRAMMQQFTFITDINIGHSQETCESTDHPEDAGES--- 2111
            ...|:..| ::..||........:..::|..:|.......||  .::||....:...::.:.   
 Frog  1822 SDSLMSSPSVSGHQPLQGKHKQSREWALRPRVQNSNKANTIN--SNEETKNVRERKVNSNQKQAS 1884

  Fly  2112 --------------PECDQNSETESCDGQEPDQLPPPPSIVDLRTSVVKPTTLEPATAVKLV--- 2159
                          |..::.|.|:....|.|....|......:|:..:..........|::.   
 Frog  1885 NIPMVLRGRTVIYVPAKEKESSTKLLQNQAPHIKDPTKVATAVRSRSLHRLGKSSDLGVEMTLPK 1949

  Fly  2160 RGRKKPAYVSPYSMQSQRNSNNAAPSKKKTL---SPTIAKRS----LVPGG----SGVRLPAKKK 2213
            |....||.:|  :..|..:|.|:.||:|...   || |:|||    ::||.    |.||:|..||
 Frog  1950 RSATPPARIS--NASSSSSSRNSTPSRKAQAPVPSP-ISKRSKNTQVLPGNKTQKSPVRIPFMKK 2011

  Fly  2214 PTP--PPEPAPARLE-------------------------------RQGTFVKDE---------- 2235
            |||  ||.|:|..:|                               ||.||:|:.          
 Frog  2012 PTPRCPPGPSPLAIEPVSPLQSPSRRPQGSRLNQVKNSESEKSGMLRQLTFIKESSGSMRRQHSD 2076

  Fly  2236 ---------PTNSNVQVPVVETKPAQTSPTHRASKLPTKKGTASGGSP---SKAGSPKRIPLAPA 2288
                     |...|..:|.|....::.... :..|.|..|.|||...|   :.:.||.|:|:   
 Frog  2077 LSVSRQHRIPPPKNSALPAVFLCSSRCEEL-KVHKQPKPKVTASPNCPPRRTSSESPSRLPV--- 2137

  Fly  2289 RRMTPQRANTSLRLAAGKSHAASRVVSGRVSSTTPPSRSNSNLNGSSAAAAAAAKINHAQSRIAN 2353
            |.:.|  |....:..:...|         ::...|......:.|.|.|..|..::.:.|.|:...
 Frog  2138 RNLPP--APEPFKRYSSSPH---------INLPGPRGECRKDQNASRAEEARVSRPHTALSQDRA 2191

  Fly  2354 IWKR------------------------VDEAKTKQSSSNLRTQ-----KTKSSNMLNANGTKPT 2389
            .|:|                        |.|.:.|.|.:.::|:     ||.||       |.||
 Frog  2192 TWRRIRDEDIPHILRSTLPACALPLTDDVSEPRRKTSDAVVQTEDIAVTKTNSS-------TSPT 2249

  Fly  2390 LLRSSTFD-NTPSTAGGV-----KSKLPVV 2413
            |..||... |.|..|..:     ||.|.||
 Frog  2250 LESSSMGSRNRPGLASSLLPELGKSALAVV 2279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcNP_001263046.1 ARM 222..316 CDD:237987 43/102 (42%)
armadillo repeat 258..332 CDD:293788 32/86 (37%)
ARM 332..448 CDD:237987 55/122 (45%)
armadillo repeat 369..403 CDD:293788 13/33 (39%)
armadillo repeat 411..448 CDD:293788 18/36 (50%)
armadillo repeat 498..539 CDD:293788 23/40 (58%)
ARM 506..624 CDD:237987 77/117 (66%)
armadillo repeat 548..582 CDD:293788 25/33 (76%)
armadillo repeat 590..624 CDD:293788 21/33 (64%)
APC_crr 837..860 CDD:283553 3/22 (14%)
APC_crr 903..927 CDD:283553 4/23 (17%)
APC_crr 1066..1090 CDD:283553 10/23 (43%)
APC_crr 1247..1271 CDD:283553 11/23 (48%)
apc2XP_002941166.2 APC_N_CC 14..65 CDD:374728 6/31 (19%)
SMC_prok_B <21..435 CDD:274008 118/440 (27%)
Suppressor_APC 130..203 CDD:371516 14/72 (19%)
APC_rep 348..420 CDD:376216 24/76 (32%)
armadillo repeat 419..462 CDD:293788 20/43 (47%)
armadillo repeat 470..507 CDD:293788 18/36 (50%)
armadillo repeat 516..549 CDD:293788 16/32 (50%)
armadillo repeat 557..598 CDD:293788 23/40 (58%)
ARM 603..643 CDD:214547 28/39 (72%)
armadillo repeat 607..641 CDD:293788 25/33 (76%)
armadillo repeat 649..683 CDD:293788 21/33 (64%)
Arm 650..683 CDD:366143 20/32 (63%)
Arm_APC_u3 686..960 CDD:374686 75/370 (20%)
APC_r 1088..>1106 CDD:368672 7/17 (41%)
SAMP 1384..1404 CDD:368673 7/51 (14%)
APC_r 1454..1476 CDD:368672 4/21 (19%)
APC_basic 1889..2157 CDD:368684 64/285 (22%)
EB1_binding <2283..>2304 CDD:368678
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 202 1.000 Domainoid score I2930
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 617 1.000 Inparanoid score I875
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm9548
Panther 1 1.100 - - LDO PTHR12607
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2812
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.060

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