DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cutlet and CTF18

DIOPT Version :9

Sequence 1:	NP_787969.1	Gene:	cutlet / 44637	FlyBaseID:	FBgn0015376	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_013795.1	Gene:	CTF18 / 855102	SGDID:	S000004683	Length:	741	Species:	Saccharomyces cerevisiae

Alignment Length:	856	Identity:	198/856 - (23%)
Similarity:	333/856 - (38%)	Gaps:	235/856 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 PFL-AIQRSDLERIYVRFHSEDYEQ---------RQLDL---ISARGEVVGSLLGEAK------- 284
            |:: ::.||.|      |.:.|.||         .:.|:   :|:.||.|......||
Yeast     6 PYIGSLGRSSL------FDTGDIEQAPGNNAIGINEEDIHAFVSSTGETVQLKKKPAKLATGNIS 64

  Fly   285 -----DKIW-----------------QEAGEIVLSRATAAEDADVT-LVNSNANSEPGRLWVDKY 326
                 |.:|                 :.:|:   .|..|.:.:.:| .:.|:.      |||:|:
Yeast    65 LYTNPDTVWRSDDTYGININYLLDKIEASGD---DRTNAQKTSPITGKIGSDT------LWVEKW 120

  Fly   327 KPRKYIDLLSDEMTNRSLLYWLKMWDKVVFGKAFHSKREQEAVTGEGGTAGGAANQLNSFNKRTG 391
            :|:|::||:.:|.|||.:|.||:.|...||      |.:...:..|
Yeast   121 RPKKFLDLVGNEKTNRRMLGWLRQWTPAVF------KEQLPKLPTE------------------- 160

  Fly   392 KFESNGGWRQRKSRQALNTNVDALGRPMQKVALLCGPPGLGKTTLAHTIARHAGYNVREINASDD 456
                         ::..:..:|.|.||.:|:.||.||||:|||::||.||:.:|::|.||||||:
Yeast   161 -------------KEVSDMELDPLKRPPKKILLLHGPPGIGKTSVAHVIAKQSGFSVSEINASDE 212

  Fly   457 RSPEAFKLALENGTQMSSVLNE--DKRPNCIVLDEIDGAPRQSIDYLVKFISDAVYTKVKA---- 515
            |:....|..:.|     .:.|.  |..|.|:|.|||||:....   .::.:.|.:.:.:||
Yeast   213 RAGPMVKEKIYN-----LLFNHTFDTNPVCLVADEIDGSIESG---FIRILVDIMQSDIKATNKL 269

  Fly   516 ----------KGAKAEHNVLKRPIICICNDVYDPALRPLRQVAFVVTFPPIDAARLAERLVKIAF 570
                      |..|....:|.||||||||::|.|:|..|:....::.........|.|||..|..
Yeast   270 LYGQPDKKDKKRKKKRSKLLTRPIICICNNLYAPSLEKLKPFCEIIAVKRPSDTTLLERLNLICH 334

  Fly   571 KEQLKTDFGSLIALAEKSGNDVRSCISSMQFF----NAQKHSLTLQDVLNNNL---GQKDRHQGL 628
            ||.:.....::..|.:.:..|||:||:::||.    :::..|.:.:.....|.   ..||.....
Yeast   335 KENMNIPIKAINDLIDLAQGDVRNCINNLQFLASNVDSRDSSASDKPACAKNTWASSNKDSPISW 399

  Fly   629 FAVWDAIFRIQRPRKTLHTDANKVDEPAQVTMTNTSVTTRVRNVLEVVHSSGDYERLTQGVYENY 693
            |.:.:.:|     ||..|.|                :..:...:|..|..:|:.:|:.||.:..:
Yeast   400 FKIVNQLF-----RKDPHRD----------------IKEQFYELLNQVELNGNSDRILQGCFNIF 443

  Fly   694 LQQKMPDPNFTGVCEALKWFCFTDTVQHQISRQQNYSVYPYLQYGFVAWHLLFATLAWPKIAFPT 758
            ...|..|...........|..|     |.:..|..|:....|        |.::.|. |.:.|.|
Yeast   444 PYVKYSDNGIRKPANISDWLFF-----HDLMYQSMYAHNGEL--------LRYSALV-PLVFFQT 494

  Fly   759 RG------------FEFQQKSTNQRN--IFQALCKGVTTSA---LGVGQGGTLLLDTVPLLKRIL 806
            .|            .|::|:...:.|  |...:.:.::..:   .......:|:.:.:|.|..::
Yeast   495 FGDIANKDDIRMKNSEYEQRELKRANSDIVSLIMRHISVQSPLMASFTDRKSLIFEILPYLDSMI 559

  Fly   807 SPQLRSVAVQLLSPKEQQDLRHTIEVMVDLGLTFVQVKSQEGHYV---FQTEPDLDALSAF-PGY 867
            |.....:....|   :|..:...::::....|..:|.:| ||..|   ...:|.:|.:... |.:
Yeast   560 SSDFNKIRNLKL---KQAIMEELVQLLKSFQLNLIQNRS-EGFDVRGGLTIDPPIDEVVLLNPKH 620

  Fly   868 TGLSLPYFSRQLIAREVDLERIRRAAPKGGAPSAPAAKKKTSGAAAQLPNHLQTLKPKPISASNM 932
                         ..||..:|....:..........|||:          |:..:....:.:..|
Yeast   621 -------------INEVQHKRANNLSSLLAKIEENRAKKR----------HIDQVTEDRLQSQEM 662

  Fly   933 HSAP------KQQLTKDFF----GRI--------THK---STSTNSAEESKTDAIVKSPIWYRYK 976
            ||..      ....|.|||    |.:        |.|   |..||.|::  .:..||  ||.:|.
Yeast   663 HSKKVKTGLNSSSSTIDFFKNQYGLLKQTQELEETQKTIGSDETNQADD--CNQTVK--IWVKYN 723

  Fly   977 EGFNNAVRKDV 987
            |||:|||||:|
Yeast   724 EGFSNAVRKNV 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cutlet	NP_787969.1	AAA	424..555	CDD:99707	52/146 (36%)
CTF18	NP_013795.1	PRK04195	116..>422	CDD:235250	101/372 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343751
Domainoid	1	1.000	64	1.000	Domainoid score	I2442
eggNOG	1	0.900	-	-		E1_KOG1969
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1060
Isobase	1	0.950	-	0	Normalized mean entropy	S4279
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005061
OrthoInspector	1	1.000	-	-		oto100266
orthoMCL	1	0.900	-	-		OOG6_102931
Panther	1	1.100	-	-	LDO	PTHR23389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R259
SonicParanoid	1	1.000	-	-		X3581
TreeFam	0	0.000	Not matched by this tool.
	13	12.770