DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cutlet and elg1

DIOPT Version :9

Sequence 1:	NP_787969.1	Gene:	cutlet / 44637	FlyBaseID:	FBgn0015376	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster

Alignment Length:	1047	Identity:	194/1047 - (18%)
Similarity:	340/1047 - (32%)	Gaps:	307/1047 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DE--NEEFELQYQDELELLEDLPDEFNAYD--GPS--------------------TSKQAAEKQK 46
            ||  .|..|||.:...:.|..:..:.:|.:  .||                    :|..|..:..
  Fly   225 DEARGEFIELQMEQRAKRLRKMLTKTDAKEVTAPSSAPTDPTVKRLRGRPRSRRISSMDAQNQIV 289

  Fly    47 ENRAPVAALRD---STRLGNSTLGSPQLSQITFGASQLGGEEEAEGTSSGGQVNRRLFGTPKGPP 108
            |::.||...:|   .|....|.|.||...:    .|.||...:.|   |..::..::....:.||
  Fly   290 ESKPPVVKAKDQDPGTEELLSKLSSPTKKR----DSLLGYFPKVE---SPKELAEKVIIAIETPP 347

  Fly   109 VGRGCSTPFQRMPAIQELENTQLTSRS-----------------YGLE---------KENAAANQ 147
            :    .||.:|....:..:.|.:.:.|                 |.||         |...|...
  Fly   348 M----ETPKRRTLRRKSQQETPIVAESTPSSRPRRSCVGKARYDYDLETSPGKQQKAKPQKADES 408

  Fly   148 LQEVGLKNVN---------------------------------------KRRLERDLFGDIDDLF 173
            ::.:.|.|.|                                       |.|.|:....:.|.::
  Fly   409 VEIIDLDNSNPAATPKKLAPLFVRQLPKPSPDPSVLKARQAFLQSGVPDKIRQEQIRQKNFDQMY 473

  Fly   174 HESYE-----------------DPM-VKKARTEEQRDHEAIERILELRRKMRESSKT-LRKDDVS 219
            .:|||                 .|: :..|...|:...|..:.:...:|:.:.||.| ....|.:
  Fly   474 EDSYEVFPRLAHIGCESFGSKNGPLDIPFALRAEEEYSEVTKALPANKRRAKASSITSCLPADFT 538

  Fly   220 RLKALHDFKMRNLSYEIPNWPFLAIQRSDLERIYVRFHSEDYEQRQLDLISARGEVVGSLLGEAK 284
            ..|.|:.|....|........|:.:.::|.:| :..|...:..:.:....||        :..|:
  Fly   539 SSKTLNKFNYATLPQLENKRGFVKLWKNDFDR-FPTFKCYNQMREKYRHFSA--------IDSAQ 594

  Fly   285 DKIWQEAGE-IVLSRAT--------AAEDADVTLVNSNANSEPGRLWVDKYKPRKYIDLLSDEMT 340
            |.  |:.|| :|::|.|        |..:.:.....|..|.|  .|:.:||||..:..:|.:...
  Fly   595 DT--QQMGESLVVTRRTRRSMEQNMAQNEEEAKPPPSAPNGE--LLFTEKYKPLLFEQVLVNLTP 655

  Fly   341 NRSLLYWLKMWDKVVFGKAFHSKREQEAVTGEGGTAGGAANQLNSFNKRTGKFESNGGWRQRKSR 405
            .:.|..:|..|                  :|.||:...:....::|:.      ||.......|.
  Fly   656 VQELREFLSSW------------------SGNGGSNRNSQGMDDTFDM------SNDSASMGSSS 696

  Fly   406 QALNTNVDALGRPMQKVALLCGPPGLGKTTLAHTIARHAGYNVREINASDDRSPEAFKLALENGT 470
               ||.|            |.||...|||....|:|....:||.||||...|:.:.....|:..|
  Fly   697 ---NTMV------------LVGPSSSGKTNAVFTLANDMNFNVLEINAGMKRTGKKLIQELQEAT 746

  Fly   471 QMSSVLNEDK-------------------------------RPNCIVLDEIDGAPRQSIDYLVKF 504
            |...:..:.|                               |.:.|::::.|    ...|.|...
  Fly   747 QSHQIRKDGKAGGGSSQQLLQKLQKSGLKAKAAAVEPPSEVRKSLILIEDAD----ILFDNLDAG 807

  Fly   505 ISDAVYTKVKAKGAKAEHNVLKRPIICICNDVYDPALRPLRQVAFVVTFPPIDAARLAERLVKIA 569
            .:||:||...:.         |||:|.:..|.....|:.|.| ..::.|...:|..::..|..::
  Fly   808 FTDAIYTLAASS---------KRPVIVVATDPNCAHLQRLMQ-QNIIHFQAPNALNISRFLAVLS 862

  Fly   570 FKEQLKTDFGSLIALAEKSGNDVRSCISSMQFFNAQKHSLTLQD-----------VLNNNLGQKD 623
            ..|....:...||::...:..::|..:..:||: .|....:.:|           ..|:.|...|
  Fly   863 LMENCPIELDELISVYLYNQQNLRKTLMELQFY-IQSGGDSTRDRTGGGIKSPTKTSNSRLATVD 926

  Fly   624 R---HQGLFAVWD---------------AIFRIQRPRKTLHTDANKVDEPAQVTMTNTSVTTRVR 670
            .   ||..|..:.               ::.|:..| ..:.:.|...::.|....:.|:...:.|
  Fly   927 GSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLP-DLMASSAMLKEQQAAGGGSRTAAKRKSR 990

  Fly   671 NVLEVVHSSGDYER---------LTQGVYENYLQQKMPDPNFTGVCEALKWFCFTDTVQHQISRQ 726
            :..:...||...::         .....|:|.....:.|.:.:   :.|:|. .::.:.|.:..|
  Fly   991 SPKKAWLSSATGQKSDGHSSSLATLASFYDNISVASLMDSDCS---DRLQWH-LSEEIGHLLVEQ 1051

  Fly   727 QNYSVYPYLQYGFVAWHLLFATLAWPKIAFPTRGFEFQQKSTNQRNIFQALCKGVTTSALGVGQG 791
            .       ||.|       .||...|        :....|...:.:|.|.|..||..|      .
  Fly  1052 A-------LQTG-------LATKECP--------YNLFDKPVQRFSICQHLGNGVLRS------D 1088

  Fly   792 GTLLLDTVPLLKRILSPQLRSVAVQLLSPKEQQDLR-HTIEV------MVDLGLTFVQVKSQEGH 849
            ....||..|.|:.|...:.....::..|.:....|| ||:.|      ..|...:..|..:....
  Fly  1089 SAKSLDFEPALRSICRSEKERAGLERKSSRFYHYLRNHTVNVTSFTTDYFDTACSTFQSAAPSSE 1153

  Fly   850 YVFQTEP 856
            ...:.||
  Fly  1154 PTMEAEP 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cutlet	NP_787969.1	AAA	424..555	CDD:99707	37/161 (23%)
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	33/153 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100