DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cutlet and Chtf18

DIOPT Version :9

Sequence 1:	NP_787969.1	Gene:	cutlet / 44637	FlyBaseID:	FBgn0015376	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_006245998.1	Gene:	Chtf18 / 287146	RGDID:	1310473	Length:	969	Species:	Rattus norvegicus

Alignment Length:	1076	Identity:	339/1076 - (31%)
Similarity:	546/1076 - (50%)	Gaps:	190/1076 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDQYPDE----NEEFELQYQDELELLEDLPDEFNAYDGPSTSKQAAEKQKENRAPVAALRDSTRL 61
            |:.|.::    .::|:.|:..|||:|.:|                 |....:.||
  Rat     1 MEDYEEDLYGVEDDFQNQFAAELEVLAEL-----------------EAGTGDLAP---------- 38

  Fly    62 GNSTLGSP-QLSQITFGASQLGGEEEAEGTSSGGQVNRRLFGTPKGPPVGRGCSTPFQRMPAIQE 125
             :.||.:| ....:||        |||   .:||.:            |.|.|       ||...
  Rat    39 -SETLQTPASRPPLTF--------EEA---IAGGDI------------VPRPC-------PAGSS 72

  Fly   126 LENTQLTSRSYGLEKENAAANQLQEVGLKNVNKRRLERD----LF-----GDI-----DDLFHES 176
            ..:::.|.::...::...::..::...|..|.:...|.|    |:     |||     .::|.|.
  Rat    73 GNDSRNTRKNVRRDQPAPSSPMVKRPRLDVVKRLNFEPDKEELLYPDSPPGDITPPPSPEVFPEM 137

  Fly   177 YEDPMVKKARTEEQRDHEAIERILELRRKMRESSKTLRKDDVSRLKALHDFKMRNLSYEIPNWPF 241
            ::     ...::...|:..::.:...|      :..||:..|     |.|:  .|::.......|
  Rat   138 WD-----AGPSDAGADNGLMQALPSPR------NPVLRRPPV-----LEDY--INVTSTCGERAF 184

  Fly   242 LAIQRSDLERIYVRFHSEDYEQR---QLDLISARGEVVGSLLGEAKDK----IWQEAGEIVLSRA 299
            |.: |:||....|:.|..|.:.|   ||||:   |....||..:..:|    :.:||.::..:..
  Rat   185 LVL-RADLTGTGVQNHLPDVQWRGRGQLDLL---GVPFTSLKEQVDNKRRQQLLEEAQQLSDTLH 245

  Fly   300 TAAEDADVTLVNSNANSEPGR--------LWVDKYKPRKYIDLLSDEMTNRSLLYWLKMWDKVVF 356
            :...:.:..::......|||.        ||||::.|:.|.:||||:.|||.||.|||:||.|||
  Rat   246 SLRSEGEEAMLEGPPEEEPGPGQETAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVF 310

  Fly   357 GKAFHSKREQEAVTGEGGTAGGAANQLNSFNKRTGK-FESNGGWRQRKS--RQALNTNVDALGRP 418
            |   |.:..::...|...|             |.|| ..:.|.|:..:.  .:.|...:|...||
  Rat   311 G---HERPARKPRPGVEPT-------------RVGKEAPAPGKWKSHEQVLEEMLEAELDPSRRP 359

  Fly   419 MQKVALLCGPPGLGKTTLAHTIARHAGYNVREINASDDRSPEAFKLALENGTQMSSVLNEDKRPN 483
            .|||||||||||||||||||.:||||||.|.|:|||||||||||:..:|..|||.|||....|||
  Rat   360 RQKVALLCGPPGLGKTTLAHVVARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGAGGRPN 424

  Fly   484 CIVLDEIDGAPRQSIDYLVKFI-------SDAVYTKVKAKGA---KAEHNVLKRPIICICNDVYD 538
            |:|:|||||||..:|:.|:..:       ::...|.|.|.|.   :||..:|.|||||||||.:.
  Rat   425 CLVIDEIDGAPTAAINVLLSILNRKGPQEAEQGGTAVAAAGGRRRRAEGGLLTRPIICICNDQFT 489

  Fly   539 PALRPLRQVAFVVTFPPIDAARLAERLVKIAFKEQLKTDFGSLIALAEKSGNDVRSCISSMQF-F 602
            |:||.|:|.|.::..||...:||.:||.:|:.:..:::|.|:|.||.||:.||:|:||:::|| :
  Rat   490 PSLRQLKQQALLLHVPPTLPSRLVQRLQEISLQHGMRSDPGALAALCEKTDNDIRACINTLQFLY 554

  Fly   603 NAQKHSLTLQDVLNNNLGQKDRHQGLFAVWDAIFRIQRPRK-------TLHTDANKVDEPAQVTM 660
            ...:..|:::||...::|.||:.:|||:||..:|::.|.::       .|.|.|..:::..:.::
  Rat   555 GRGQRELSVKDVQTTHVGLKDQRKGLFSVWQEVFQLPRAQRRLVGQDLMLPTHALLLNDSDKGSL 619

  Fly   661 TNTSVTTRVRNVLEVVHSSGDYERLTQGVYENYLQQKMPDPNFTGVCEALKWFCFTDTVQHQISR 725
            |..|  .|..::|.|..|:|::|::.||:::|:|:.::.|.:...||.||.|..|.|.::.....
  Rat   620 TLAS--QRFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLGTVCCALDWLAFDDLLEQAAHH 682

  Fly   726 QQNYSVYPYLQYGFVAWHLLFATLAWPKIAFPTRGFEFQQKSTNQRNIFQALCKGVTTSALGVGQ 790
            .|::.:..||.:...|:|:|||:...|:|.||:...|.|.:.:..||..|.|..|:..:......
  Rat   683 GQSFQLLRYLPFLPAAFHVLFASSHVPRITFPSSQQEAQTRLSQTRNHIQTLVSGMAPATRSRAT 747

  Fly   791 GGTLLLDTVPLLKRILSPQLRSVAVQLLSPKEQQDLRHTIEVMVDLGLTFVQVKSQEGHYVFQTE 855
            ...|:|||:.||..:|||:||.|:.||.|.:|:|.|...:..|:...||:.|.::.:|.|:::.|
  Rat   748 PQALVLDTLCLLLDVLSPKLRPVSTQLYSAREKQQLSSLVGTMLAYSLTYHQERTPDGQYLYRLE 812

  Fly   856 PDLDALSAFPGYTGLS-LPYFSRQLIAREVDLERIRRA---APKGG------APSAPAAKKKTSG 910
            |:::.:..||...... |.|.::||||||:::|::.||   |..||      .||.||..:..||
  Rat   813 PNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMWRAEALAWTGGGPQVDQGPSGPANLRTDSG 877

  Fly   911 -AAAQLP---NHLQTLKPKPISASNMH----SAPKQQLTKDFFGRITHKSTSTNSAE----ESKT 963
             ...:.|   ||.|.|:         |    :|.::|..:|||||:..:..:..|.|    :..|
  Rat   878 EKGTRQPAPRNHEQRLE---------HIMKRAAVQEQPERDFFGRVVIRKVAVPSKEVEAPQKDT 933

  Fly   964 D------AIVKSPIWYRYKEGFNNAVRKDVHIHELL 993
            |      |:.:|.:|:|:.||.:||||:.::|.:||
  Rat   934 DEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cutlet	NP_787969.1	AAA	424..555	CDD:99707	77/140 (55%)
Chtf18	XP_006245998.1	AAA	346..516	CDD:99707	89/169 (53%)
Chtf18	XP_006245998.1	DNA_pol3_delta	<486..553	CDD:303078	27/66 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340679
Domainoid	1	1.000	256	1.000	Domainoid score	I1963
eggNOG	1	0.900	-	-		E1_KOG1969
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32532
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1558
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291910at33208
OrthoFinder	1	1.000	-	-		FOG0005061
OrthoInspector	1	1.000	-	-		oto98593
orthoMCL	1	0.900	-	-		OOG6_102931
Panther	1	1.100	-	-	LDO	PTHR23389
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3581
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760