DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cutlet and ctf18

DIOPT Version :9

Sequence 1:	NP_787969.1	Gene:	cutlet / 44637	FlyBaseID:	FBgn0015376	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_595200.1	Gene:	ctf18 / 2541270	PomBaseID:	SPBC902.02c	Length:	960	Species:	Schizosaccharomyces pombe

Alignment Length:	1089	Identity:	272/1089 - (24%)
Similarity:	434/1089 - (39%)	Gaps:	227/1089 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDQYPDENEEFELQYQDELELL-------------EDLPDEFNAYDGPSTSKQAAEKQKENRAPV 52
            ||..|:|         |:||.|             |...||.| |.....:..|.|..:....|.
pombe     1 MDSIPNE---------DDLEKLLVAEQNVPYGKNYESFEDEEN-YLLELRNANALENLEHRSIPN 55

  Fly    53 AALRDSTRLGNSTLGSPQL-SQITFGASQLG------GEEEAEGTSSGGQVNRRLFGTPKGPPVG 110
            .....|..:|:.|.....: |.:...:|...      .|:|........|.:.|...|...|.:|
pombe    56 DLFHSSQPVGSPTRNGDDIPSTLDLYSSDNAAIDTDISEDETINQRHAPQTDYRYPNTSANPKMG 120

  Fly   111 RGCSTPFQRMPAIQ-ELEN-------TQLTSRSY-------------GLEKENAAANQLQEVGLK 154
            ...|.... ||:|. ::.|       :.|..|:|             ..||||..:|.|...|..
pombe   121 LEESMDID-MPSIDLDISNAAAFPRDSNLLFRNYNSHTKTSEKGSPVNFEKENQDSNVLFSTGRT 184

  Fly   155 NVNKRRLERD--------LFGDIDDLFHESYEDPMVKKARTEEQRDHEAIERILELRRKMRESSK 211
            :|.....|:.        |..|...||  |:|:. |..|..:...|    :::...:...|.|..
pombe   185 SVLHIDAEQSQTNNTVTPLKDDALSLF--SFEND-VNGAVNDNSLD----QKLSASKNSQRVSLP 242

  Fly   212 TLRKDDVSRLKALHDFKMRNLSYEIPNWPFLAIQRSDLERIYV----RFHSED---YEQRQLDLI 269
            ...|.::....:.             :.|.::.:.|..:.||.    ..||:.   ..:|..|.|
pombe   243 FFSKIELDEGSSF-------------SGPKISARTSSGKIIYFPKKKNRHSDGLLLQPKRLADEI 294

  Fly   270 SARGEVVGSLLGEAKD---------KIWQEAGEIVLSRATAA---EDAD-VTLVNSNANSEPGRL 321
            |...|:       .||         :||.|...||....:.|   |..| :.:.|.....:..:|
pombe   295 SQVNEI-------GKDFNQDLLNSVRIWSENFLIVSKEKSVALKTEKLDSLQITNCTTKPQSQKL 352

  Fly   322 WVDKYKPRKYIDLLSDEMTNRSLLYWLKMWDKVVFGKAFHSKREQEAVTGEGGTAGGAANQLNSF 386
            |||.|:|:.:.|||.||..:|:.::|:|.||..||||:    |.|             .::...|
pombe   353 WVDTYRPQLFRDLLGDERVHRAAMHWIKAWDPCVFGKS----RLQ-------------PSKSMRF 400

  Fly   387 NKRTGKFESNGGWRQRKSRQALNTNVDALGRPMQKVALLCGPPGLGKTTLAHTIARHAGYNVREI 451
            |.|.....|:.                  .||.:::.:|.|..|.|||||||.||..|||.|.||
pombe   401 NPRFTNITSDS------------------DRPDKRIMMLTGLAGAGKTTLAHVIAHQAGYKVLEI 447

  Fly   452 NASDDRSP----EAFKLALENGTQMSSVLNEDKRPNCIVLDEIDGAPRQSIDYLVKFI-SDAVYT 511
            ||||||:.    |....|:.|.:.:||      :|.|:::|||||.....:..|:..: ||...|
pombe   448 NASDDRTAHTVHEKVSSAISNHSALSS------QPTCVIVDEIDGGDPAFVRALLSLLESDEKAT 506

  Fly   512 KVKAKG---AKAEHNVLKRPIICICNDVYDPALRPLRQVAFVVTFPPIDAARLAERLVKIAFKEQ 573
            :....|   .|.:...|.|||||||||:|.|||||||..|.::.|.|...|.|..||..|...|.
pombe   507 EYSQAGNSKKKKKFKKLCRPIICICNDLYTPALRPLRPYAQIIYFRPPPQASLVGRLRTICRNEN 571

  Fly   574 LKTDFGSLIALAEKSGNDVRSCISSMQFFN-----AQKHSLTLQDVLNNNLGQKDRHQGLFAVWD 633
            :..|..||..|.:...:|:||||:|:|..:     ....::.|....:|:.......|.||
pombe   572 IAVDSRSLTLLTDIYNSDIRSCINSLQLLSLNNKRIDSETIKLLQPKSNSFSTSSLIQSLF---- 632

  Fly   634 AIFRIQRPRKTLHTDANKVDEPAQVTMTNTSVTTRVRNVLEVVHSSGDYERLTQGVYENYLQQKM 698
                :|...|.:     :..|.:|.|.::...      :|..:..:.|.|.:....:..||....
pombe   633 ----LQLDNKQI-----RAIEASQPTYSHLDA------LLARIDGANDSESVLMNCFHTYLDLPF 682

  Fly   699 PDPNFTGVCEALKWFCFTDTVQHQISRQQNYSVYPYLQYGFVAWHLLFATLAWPKIAFPTRG-FE 762
            .|...:......:|..|.|.: |....:.||.::.|:.|..:.:|.|:||....::..|.|. .|
pombe   683 TDSLLSKPALTSEWLYFFDQL-HSQCYKGNYELWRYIPYSIIHFHYLYATPEKCRLPHPPRSDLE 746

  Fly   763 FQQKSTNQRNIFQALCKGVTTSALGVGQGGTLLLDTVPLLKRILSPQLRSVAVQLLSPKEQQDLR 827
            ..:....::.|..:....:......:....::||:.:..:...::|.|:.....:........:.
pombe   747 ALKLYRTRKEILDSFISTLNAYENQMHGERSILLELIRTILITINPTLKQKEDSMPRSALPSKIE 811

  Fly   828 HTIEVMVDLGLTFVQVKSQEGHYVFQTEPDLDALSAFPGYTGLSLPYFSRQLIAREVDLERIRRA 892
            |.|.::....|.|.|:...:|:||::.||.||.|.    :...:..|..||::::|:..:|:
pombe   812 HAINILNHYNLRFQQLPVGDGNYVYRLEPPLDELV----WDAPTSSYSVRQMLSQELLKKRL--- 869

  Fly   893 APKGGAPSAPAAKKKTSGAAAQLPNHLQTLKPKPISASNMHSAPKQQ-------LTKDFFGRI-- 948
                      |..||            |||...|.|:   :|:.|::       :.:||||||
pombe   870 ----------ADIKK------------QTLTDNPTSS---NSSRKRKDFNSGKAIKRDFFGRIIS 909

  Fly   949 ---THKSTSTNSAEESKTDAI-VKSPIWYRYKEGFNNAVRKDVHIHELL 993
               :...||.|:|..:....: :|..|..::.:||:|||||.:.::|:|
pombe   910 EPKSEAVTSNNAALNTGDHPVSIKHAINIKFHDGFSNAVRKPISLNEIL 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cutlet	NP_787969.1	AAA	424..555	CDD:99707	62/138 (45%)
ctf18	NP_595200.1	AAA	412..553	CDD:99707	64/146 (44%)
		AAA	416..554	CDD:214640	62/143 (43%)
		HolB	482..>647	CDD:223546	57/177 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	115	1.000	Domainoid score	I1529
eggNOG	1	0.900	-	-		E1_KOG1969
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I854
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005061
OrthoInspector	1	1.000	-	-		oto102027
orthoMCL	1	0.900	-	-		OOG6_102931
Panther	1	1.100	-	-	LDO	PTHR23389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R259
SonicParanoid	1	1.000	-	-		X3581
TreeFam	1	0.960	-	-
	12	11.850