DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and CYP86A4

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_171666.1	Gene:	CYP86A4 / 839347	AraportID:	AT1G01600	Length:	554	Species:	Arabidopsis thaliana

Alignment Length:	571	Identity:	147/571 - (25%)
Similarity:	221/571 - (38%)	Gaps:	129/571 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDNFRYWIGYYS 79
            :||.:.|...|..|.|   :||.:.||      :|:.|..|..|  ...||:..:|.|...|.|.
plant    12 IVTGYWLWFKRISRWL---KGPRVWPL------LGSLPGLIEQR--DRMHEWITENLRACGGTYQ 65

  Fly    80 N--------------IMVT-NPKYMEFILSSQTLISKSDVY-------DLTHPWLGLGLLTSTGS 122
            .              :.|| :||.:|.:|.     ::.|.|       .:.|..||.|:..|.|.
plant    66 TCIFAVPFLAKKQGLVTVTCDPKNLEHMLK-----TRFDNYPKGPTWQSVFHDLLGQGIFNSDGD 125

  Fly   123 KWHKHRKMITPAFHF---NILQDFHEVMNEN-STKFIDQLKKVADGGNIFDFQEEAHYLTLDVIC 183
            .|...||  |.|..|   .:.|.....:|.. ..:|...|....|.....|.|:....||.|.||
plant   126 TWLFQRK--TAALEFTTRTLRQAMGRWVNRGIKLRFCPILATAQDNAEPVDLQDLILRLTFDNIC 188

  Fly   184 DTAMGVSINAM-----ENRSSSVVQAFKDITYTIKMRAFSP---WKRNKYLFHFAPEYPEYSKTL 240
            ..|.|......     ||..:|   ||...|.....|...|   ||..|:| ....|. ..|::|
plant   189 GLAFGKDTRTCAPGLPENGFAS---AFDRATEASLQRFIIPKFMWKLKKWL-GLGLEV-SLSRSL 248

  Fly   241 KTLQDFTNEIIAKRIEVRKSGLEVGIKA---DEFSR----KKMAFLDTLLSSKVDGRPLTSQELY 298
            ..:.::...:|..|.:...|..|.|...   |..||    |..::.||.|
plant   249 GEIDEYLAAVINTRKQELMSQQESGTHQRHDDLLSRFMMKKTESYSDTFL--------------- 298

  Fly   299 EEVS-TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVM--------GASGLGRDATFQE 354
            :.|: .|:..|.||::..:.:..:|::.||..::|:..|.|.|:        .||.......|.|
plant   299 QHVALNFILAGRDTSSVALSWFFWLITMHPTVEDKIVREICSVLIETRGTDDVASWTEEPLGFDE 363

  Fly   355 ISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVF-KDPH 417
            |..:.:|...|.|..|||||||...:..|.|.|: ||..||.|:::...:...|.....: :|..
plant   364 IDRLVYLKAAISETLRLYPSVPEDSKHVENDDVLPDGTFVPAGSSVTYSIYAAGRMKSTWGEDCL 428

  Fly   418 KFQPERFDREKPGPF------EYVPFSAGPRNCIGQKFALLEIKTVVSKII--RNFEVLPALDEL 474
            :|.|||:.....|.|      .:|.|:||||.|:|:..|.|::||:.:.::  ....|:|
plant   429 EFNPERWISPIDGKFINHDQYRFVAFNAGPRICLGKDLAYLQMKTIAAAVLLRHRLTVVP----- 488

  Fly   475 VSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMKQR 525
                                    .||.:.  ..|:||..:|||.:.:.:|
plant   489 ------------------------GHKVEQ--KMSLTLFMKNGLLVNLYKR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	131/494 (27%)
CYP86A4	NP_171666.1	PLN03195	5..513	CDD:215627	146/569 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920