DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and CYP86A1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_200694.1	Gene:	CYP86A1 / 836003	AraportID:	AT5G58860	Length:	513	Species:	Arabidopsis thaliana

Alignment Length:	581	Identity:	135/581 - (23%)
Similarity:	229/581 - (39%)	Gaps:	146/581 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDNF 71
            |..||.::.:.::.|.        .:..||.:||.|      |:.|..|.||  ...|::..||.
plant    12 AVAALSVYALWFYFLS--------RRLTGPKVLPFV------GSLPYLIANR--SRIHDWIADNL 60

  Fly    72 RYWIGYYSN---------------IMVTNPKYMEFILSSQTLISKSDVYDLTHPW-------LGL 114
            |...|.|..               .:..:||.:|.||.     ::.|.|.....|       ||.
plant    61 RATGGTYQTCTMVIPFVAKAQGFYTVTCHPKNVEHILK-----TRFDNYPKGPMWRAAFHDLLGQ 120

  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQ---------LKKVADGGNIFDF 170
            |:..|.|..|...||  |.|..|..     ..:.:...::::.         |.:........|.
plant   121 GIFNSDGDTWLMQRK--TAALEFTT-----RTLRQAMARWVNGTIKNRLWLILDRAVQNNKPVDL 178

  Fly   171 QEEAHYLTLDVICDTAMG-----VSINAMENRSSSVVQAFKDIT-YTIKMRAFSP--WKRNKYLF 227
            |:....||.|.||....|     :|::..:|..|   .||...| .|:|...::.  |:..|.:.
plant   179 QDLFLRLTFDNICGLTFGKDPETLSLDLPDNPFS---VAFDTATEATLKRLLYTGFLWRIQKAMG 240

  Fly   228 HFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLS-----SKV 287
            ..:.:  :..|:|:.::.:.|:    .|:.||:...                |.|||     ..|
plant   241 IGSED--KLKKSLEVVETYMND----AIDARKNSPS----------------DDLLSRFLKKRDV 283

  Fly   288 DGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRD--- 349
            :|..|.:..|......|:..|.||::..:.:..:|:..:.:.:.|:.||...|:..: .|.|
plant   284 NGNVLPTDVLQRIALNFVLAGRDTSSVALSWFFWLVMNNREVETKIVNELSMVLKET-RGNDQEK 347

  Fly   350 -----ATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGY 408
                 ..|.|...:.:|...:.|..|||||||...::...|.|: ||..||:|:|:...:..:|.
plant   348 WTEEPLEFDEADRLVYLKAALAETLRLYPSVPQDFKYVVDDDVLPDGTFVPRGSTVTYSIYSIGR 412

  Fly   409 NDRVF-KDPHKFQP--------ERFDREKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRN 464
            ...:: :|..:|:|        |||:..|.| :::|.|:||||.|:|:..|..::|:|.|.::..
plant   413 MKTIWGEDCLEFRPERWLTADGERFETPKDG-YKFVAFNAGPRTCLGKDLAYNQMKSVASAVLLR 476

  Fly   465 FEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMKQR 525
            :.|.|.....|               |:|              .|:||..:|||.:.::.|
plant   477 YRVFPVPGHRV---------------EQK--------------MSLTLFMKNGLRVYLQPR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	120/496 (24%)
CYP86A1	NP_200694.1	CYP86A	70..501	CDD:410687	112/498 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920