DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and CYP714A1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_568463.1	Gene:	CYP714A1 / 832560	AraportID:	AT5G24910	Length:	532	Species:	Arabidopsis thaliana

Alignment Length:	588	Identity:	130/588 - (22%)
Similarity:	235/588 - (39%)	Gaps:	139/588 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPL--FLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILN---RFFG 61
            |||:...|.|.:  :.....|...:|||..:...:||......||..:|....::|::   .:.|
plant    14 WIVVIGVLGLGIRVYGKVMAEQWRMRRKLTMQGVKGPPPSLFRGNVPEMQKIQSQIMSNSKHYSG 78

  Fly    62 ------------------WWHEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTL-ISK-SDVYD 106
                              |..:||: .:.|..|...::.:.:|:.::.:..:.|| :.| |.|..
plant    79 DNIIAHDYTSSLFPYLDHWRKQYGR-VYTYSTGVKQHLYMNHPELVKELNQANTLNLGKVSYVTK 142

  Fly   107 LTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENS----TKFIDQLKKVADGGNI 167
            .....||.|::||.|..|...|::|.|.|..:.::....::.|::    :|:.:.:|:  :|..:
plant   143 RLKSILGRGVITSNGPHWAHQRRIIAPEFFLDKVKGMVGLVVESAMPMLSKWEEMMKR--EGEMV 205

  Fly   168 FDF--QEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFA 230
            .|.  .|:....:.|||.....|.|.:..:...|.:....|.||:            |..||
plant   206 CDIIVDEDLRAASADVISRACFGSSFSKGKEIFSKLRCLQKAITH------------NNILF--- 255

  Fly   231 PEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSR--------------------KK 275
                       :|..||:.:..    .:|.|   ..|.||..|                    .|
plant   256 -----------SLNGFTDVVFG----TKKHG---NGKIDELERHIESLIWETVKERERECVGDHK 302

  Fly   276 MAFLDTLLS---SKVDGRPLTSQELY-----EEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEK 332
            ...:..:|.   |..||......:.|     :...:..|.||:|:...|.:.:.||:.:|..|.:
plant   303 KDLMQLILEGARSSCDGNLEDKTQSYKSFVVDNCKSIYFAGHETSAVAVSWCLMLLALNPSWQTR 367

  Fly   333 LFNE---QCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVP 394
            :.:|   .|    .:|: .||  ..||.:|.:.:.|:|..||||...|:.|...:|..:...:||
plant   368 IRDEVFLHC----KNGI-PDA--DSISNLKTVTMVIQETLRLYPPAAFVSREALEDTKLGNLVVP 425

  Fly   395 KGTTLNLGLLMLGYNDRVF-KDPHKFQPERF----DREKPGPFEYVPFSAGPRNCIGQKFALLEI 454
            ||..:...:..|..:..:: .|.::|.||||    .:....|..:|||..|.|.|:|:.|.::|:
plant   426 KGVCIWTLIPTLHRDPEIWGADANEFNPERFSEGVSKACKHPQSFVPFGLGTRLCLGKNFGMMEL 490

  Fly   455 KTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLH 519
            |.:||.|:..|                |.||           :..:::.|:.  .|.::.::|:.
plant   491 KVLVSLIVSRF----------------SFTL-----------SPTYQHSPVF--RMLVEPQHGVV 526

  Fly   520 LRM 522
            :|:
plant   527 IRV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	114/499 (23%)
CYP714A1	NP_568463.1	p450	37..530	CDD:299894	124/565 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	160	1.000	Domainoid score	I1269
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960