DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and CYP94B3

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_190421.1	Gene:	CYP94B3 / 824011	AraportID:	AT3G48520	Length:	506	Species:	Arabidopsis thaliana

Alignment Length:	564	Identity:	141/564 - (25%)
Similarity:	242/564 - (42%)	Gaps:	111/564 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LCAFLALPLFLVT--YFELGLLRRKRMLNKFQGPSMLPLVG-------NAHQMGNTPTEILNRFF 60
            |.:||.| .||:|  :|......:|...|...||...||:|       |.|::....||:|..
plant     4 LLSFLIL-AFLITIIFFLSSSSTKKVQENTTYGPPSYPLIGSILSFNKNRHRLLQWYTELLRL-- 65

  Fly    61 GWWHEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTL-ISKSDVY-DLTHPWLGLGLLTSTGSK 123
                ...:......:|....|:.|||..:|:||.:... ..|...: ||....||.|:....|..
plant    66 ----SPSQTILVPLLGNRRTIITTNPLNVEYILKTNFFNFPKGKPFTDLLGDLLGGGIFNVDGHS 126

  Fly   124 WHKHRKMITPAFHFNILQDF-HEVM-NENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTA 186
            |...||:.:..|....|:.| .||: :|...:.:..|...||.|...|.|:.......||:|..:
plant   127 WSSQRKLASHEFSTRSLRSFAFEVLKDEVENRLVPVLSTAADVGTTVDLQDVLKRFAFDVVCKVS 191

  Fly   187 MGVSINAME--NRSSSVVQAFKDITYTIKMRAFSP----WKRNKYLFHFAPEYPEYSKTLKTLQD 245
            :|...:.::  ...:.:|:||.........||..|    || .|.:.:...| .:..:.::|:..
plant   192 LGWDPDCLDLTRPVNPLVEAFDTAAEISARRATEPIYAVWK-TKRVLNVGSE-RKLREAIRTVHV 254

  Fly   246 FTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHD 310
            ..:||    :..:|..||:|..|:    .|...|...|::..:|     :.:.:.|.:|:..|.|
plant   255 LVSEI----VRAKKKSLEIGTGAE----AKQDLLSRFLAAGHNG-----EAVRDMVISFIMAGRD 306

  Fly   311 TTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSV 375
            ||::.:.:..:||:.:.|.:.|:. |:.|.:.:.|||    |:::..|.:....:.||.||||.|
plant   307 TTSAAMTWLFWLLTENDDVERKIL-EEVDPLVSLGLG----FEDLKEMAYTKACLCEAMRLYPPV 366

  Fly   376 PFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVF--------------KDPHKFQPERFDR 426
            .:..:....|     |::|.||.:..|       |:|.              .|..:|.|.|:..
plant   367 SWDSKHAAND-----DVLPDGTRVKRG-------DKVTYFPYGMGRMETLWGTDSEEFNPNRWFD 419

  Fly   427 EKPG----------PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYI 481
            .:||          |:::..|.||||.|:|::.|.:::|.||..::..||::|     |:||
plant   420 SEPGSTRPVLKPISPYKFPVFQAGPRVCVGKEMAFMQMKYVVGSVLSRFEIVP-----VNKD--- 476

  Fly   482 STTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMKQR 525
                  :|.           :.|:|:|.|.    .||.:::|:|
plant   477 ------RPV-----------FVPLLTAHMA----GGLKVKIKRR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	118/475 (25%)
CYP94B3	NP_190421.1	p450	46..501	CDD:386267	126/521 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920