DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and CYP709B2

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_182218.2	Gene:	CYP709B2 / 819309	AraportID:	AT2G46950	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	521	Identity:	135/521 - (25%)
Similarity:	223/521 - (42%)	Gaps:	81/521 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTE----------------ILNRFFGWWHEYGKDNF 71
            :|.|:.......||....|.||..::.....|                :|.....|..:|| :.|
plant    90 MLSRRFKKQGISGPKYRILYGNLREIRKMKNEAKLMVLDPNSNDIVPRVLPHLQQWKSQYG-ETF 153

  Fly    72 RYWIGYYSNIMVTNPKYMEFILSSQ-TLISKSDVYDLTHPWL----GLGLLTSTGSKWHKHRKMI 131
            .||.|....:.:::.:..:.|||:: ...|||.    |.|.:    |.||:...|..|.:||:::
plant   154 LYWQGTDPRLCISDHELAKQILSNKFVFFSKSK----TKPEILKLSGNGLIFVNGLDWVRHRRIL 214

  Fly   132 TPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDF---QEEAHYLTLDVICDTAMGVSINA 193
            .|||..:.|:...::|.:.:.:...:.||..:|.....|   ..|...||.|:|...|.|.|.
plant   215 NPAFSMDKLKLMTQLMVDCTFRMFLEWKKQRNGVETEQFVLISREFKRLTADIIATAAFGSSY-- 277

  Fly   194 MENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYP--EYSKTLKTLQDF-----TNEII 251
                 :..::.||......|..|.:  ..:.|       :|  :|..|...||.:     .|..|
plant   278 -----AEGIEVFKSQLELQKCCAAA--LTDLY-------FPGIQYLPTPSNLQIWKLDMKVNSSI 328

  Fly   252 AKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGV 316
            .:.|:.|.:.     ::.::....:..:.|..||....:.::..|:.||..||.|.||:||.:.:
plant   329 KRIIDARLTS-----ESKDYGNDLLGIMLTAASSNESEKKMSIDEIIEECKTFFFAGHETTANLL 388

  Fly   317 GFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRF 381
            .::..|||.|.|.||||..|   |....|..:....:..|.:|.::....|:.|||..|..:.|.
plant   389 TWSTMLLSLHQDWQEKLREE---VFNECGKDKIPDAETCSKLKLMNTVFMESLRLYGPVLNLLRL 450

  Fly   382 TEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVF-KDPHKFQPERF----DREKPGPFEYVPFSAGP 441
            ..:|..:....:|||||:.|.:..:..:..|: .|..||.|.||    .|....|...:.||.||
plant   451 ASEDMKLGNLEIPKGTTIILPIAKMHRDKAVWGSDADKFNPMRFANGLSRAANHPNALLAFSMGP 515

  Fly   442 RNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYD-PI 505
            |.||||.||::|.|||::.|::.|.:..:.|...:...:::    |||           :|| |:
plant   516 RACIGQNFAIMEAKTVLAMILQRFRLNLSADYKHAPADHLT----LQP-----------QYDLPV 565

  Fly   506 L 506
            :
plant   566 I 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	126/470 (27%)
CYP709B2	NP_182218.2	p450	89..571	CDD:299894	135/521 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860