DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	543	Identity:	158/543 - (29%)
Similarity:	264/543 - (48%)	Gaps:	70/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALPLFLVTYFELGL---------LRRKRM---LNKFQGPSMLPLVGNAH--QMGNTPT--EILNR 58
            |.||.|...|.|.|         |||:|:   |:.|.||....|:|:..  |..|..|  ||:.:
Mouse    11 ARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKK 75

  Fly    59 FFGWWHEYGKDNFRYWIG-YYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGS 122
                 |...   |..|:| :.:...:.:|.|.:..| |:|......::.|..|.:|.|||...|.
Mouse    76 -----HPCA---FPCWVGPFQAFFYIYDPDYAKIFL-SRTDPKMQYLHQLLTPCIGRGLLNLDGP 131

  Fly   123 KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKV-ADGGNIFDFQEEAHYLTLDVICDTA 186
            :|.:||.::|||||.:||:...:.|..:....:|:.:|: .......:..|..:.:|||:|...|
Mouse   132 RWFQHRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCA 196

  Fly   187 MGVSINAMENRS-SSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEI 250
            .|...|...|.: .|.|:|..::...|..|.::.|..:..:|..:|:...:.:..|.:..:|.:|
Mouse   197 FGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYTEKI 261

  Fly   251 IAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKV-DGRPLTSQELYEEVSTFMFEGHDTTTS 314
            |..|.::.|:    .:|.|: ::....|||.:||::. |.|..:..:|..||:|||:.|||.:.:
Mouse   262 IQDRKKILKN----QVKQDD-TQTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDASAA 321

  Fly   315 GVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIG 379
            .:.:.:|.|:.:|:.|::...|...::|.   |...|::::..|.:..:.|||..||.|.||.|.
Mouse   322 SISWLLYCLALNPEHQDRCRTEIRSILGD---GSSITWEQLDEMSYTTMCIKETLRLIPPVPSIS 383

  Fly   380 RFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG---PFEYVPFSAG 440
            |...|...: ||..:|.|.|:.|.:..|.:|..|:.||..|.|.||.:|...   |..::|||:|
Mouse   384 RELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPFSSG 448

  Fly   441 PRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPI 505
            |||||||:||:||:|..::.|:.:|:|.|.|..                             .|.
Mouse   449 PRNCIGQQFAMLELKVAIALILLHFQVAPDLTR-----------------------------PPA 484

  Fly   506 LSASMTLKSENGLHLRMKQRLVC 528
            .|:...|:.::|::|.:|:.|.|
Mouse   485 FSSHTVLRPKHGIYLHLKKLLEC 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	135/446 (30%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	141/497 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750