Protein Alignment Cyp4e1 and Cyp4x1

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001003947.1
• Gene: Cyp4x1 / 81906
• MGIID: 1932403
• Length: 507
• Species: Mus musculus
• Alignment Length: 543
• Identity: 158/543 - (29%)
• Similarity: 264/543 - (48%)
• Gaps: 70/543 - (12%)

  Fly    10 ALPLFLVTYFELGL---------LRRKRM---LNKFQGPSMLPLVGNAH--QMGNTPT--EILNR 58
            |.||.|...|.|.|         |||:|:   |:.|.||....|:|:..  |..|..|  ||:.:
Mouse    11 ARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKK 75

  Fly    59 FFGWWHEYGKDNFRYWIG-YYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGS 122
                 |...   |..|:| :.:...:.:|.|.:..| |:|......::.|..|.:|.|||...|.
Mouse    76 -----HPCA---FPCWVGPFQAFFYIYDPDYAKIFL-SRTDPKMQYLHQLLTPCIGRGLLNLDGP 131

  Fly   123 KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKV-ADGGNIFDFQEEAHYLTLDVICDTA 186
            :|.:||.::|||||.:||:...:.|..:....:|:.:|: .......:..|..:.:|||:|...|
Mouse   132 RWFQHRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCA 196

  Fly   187 MGVSINAMENRS-SSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEI 250
            .|...|...|.: .|.|:|..::...|..|.::.|..:..:|..:|:...:.:..|.:..:|.:|
Mouse   197 FGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYTEKI 261

  Fly   251 IAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKV-DGRPLTSQELYEEVSTFMFEGHDTTTS 314
            |..|.::.|:    .:|.|: ::....|||.:||::. |.|..:..:|..||:|||:.|||.:.:
Mouse   262 IQDRKKILKN----QVKQDD-TQTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDASAA 321

  Fly   315 GVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIG 379
            .:.:.:|.|:.:|:.|::...|...::|.   |...|::::..|.:..:.|||..||.|.||.|.
Mouse   322 SISWLLYCLALNPEHQDRCRTEIRSILGD---GSSITWEQLDEMSYTTMCIKETLRLIPPVPSIS 383

  Fly   380 RFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG---PFEYVPFSAG 440
            |...|...: ||..:|.|.|:.|.:..|.:|..|:.||..|.|.||.:|...   |..::|||:|
Mouse   384 RELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPFSSG 448

  Fly   441 PRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPI 505
            |||||||:||:||:|..::.|:.:|:|.|.|..                             .|.
Mouse   449 PRNCIGQQFAMLELKVAIALILLHFQVAPDLTR-----------------------------PPA 484

  Fly   506 LSASMTLKSENGLHLRMKQRLVC 528
            .|:...|:.::|::|.:|:.|.|
Mouse   485 FSSHTVLRPKHGIYLHLKKLLEC 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	131/459 (29%)
Cyp4x1	NP_001003947.1	CYP4B-like	66..500	CDD:410771	135/479 (28%)