DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	475	Identity:	135/475 - (28%)
Similarity:	236/475 - (49%)	Gaps:	61/475 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KDNFRYWIGYYSNIM-VTNPKYMEFILSSQTLISKSDVYDL--THPWLGLGLLTSTGSKWHKHRK 129
            :|...:|:|....:: :.:|.::..:|.:..|::..|:..|  ..||||.||..|:|.||.:||:
Mouse    85 QDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGLFLSSGDKWSRHRR 149

  Fly   130 MITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNI-FDFQEEAHYLTLDVICDTAMGVSINA 193
            ::||||||:||:.:.::.|::......:.|.::..|:. .:..|....:|||.:.....|...|.
Mouse   150 LLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNC 214

  Fly   194 MENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVR 258
            .|: .|..:.|..:::..|..|:...:....:|::...:...:.|....:.:||:.:|.:|....
Mouse   215 QES-PSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIRERRHTL 278

  Fly   259 KSGLEVGIKADEFSRKK-----MAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHDTTTSGVG 317
            .|.     ..|||.:.|     :.|:|.||.:|.: |:.|:.:::..|..||||.|||||.|.:.
Mouse   279 SSQ-----NHDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALS 338

  Fly   318 FAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEI-----STMKHLDLFIKEAQRLY-PSVP 376
            :.:|.|:|||:.||:...|..:::      ||...:||     :.:..|.:.|||:.||: |.:.
Mouse   339 WILYNLARHPEYQERCRQEVQELL------RDREPEEIEWDDLAQLPFLTMCIKESLRLHSPVID 397

  Fly   377 FIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP---GPFEYVPFS 438
            .:.|.|....:.||.::|||....:.:..:.:|..|:.||..:.|.|||.|.|   .|..::|||
Mouse   398 LLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENPQKRSPLAFIPFS 462

  Fly   439 AGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYD 503
            |||||||||.||:.|:|..::..:..|.:||  |:                            .:
Mouse   463 AGPRNCIGQTFAMSEMKVALALTLLRFRILP--DD----------------------------KE 497

  Fly   504 PILSASMTLKSENGLHLRMK 523
            |.....:.|::|.||.||::
Mouse   498 PRRKPEIILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	125/419 (30%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	133/470 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640