DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and cyp46a1.3

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001038763.1	Gene:	cyp46a1.3 / 692332	ZFINID:	ZDB-GENE-060519-40	Length:	491	Species:	Danio rerio

Alignment Length:	507	Identity:	128/507 - (25%)
Similarity:	227/507 - (44%)	Gaps:	72/507 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPLFLVTY--FELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNR------ 58
            |::...|..|....|.:  :.|.:.:..:..:...||..     :...:|:.||  :||
Zfish     5 WLLYMVFYLLSAVFVVFLAYCLYIHQVHQKYDHIPGPPR-----DNFLLGHIPT--INRVTKSER 62

  Fly    59 -----FFGWWHEYGK----DNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYD-----LTH 109
                 ...|..:||.    ::|.|.|     |.|..|:..:.|:.|...:....:|.     ...
Zfish    63 HMNDLLLIWAEKYGPVYRLNSFHYVI-----INVHCPEATKTIMMSPKYLKDPFIYKRLFGLFGK 122

  Fly   110 PWLGLGLLTSTGSK-WHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEE 173
            .:||.||:|:|... |::.|:::.|||..:.|:......||.|.:.:|:|:::|.........:.
Zfish   123 RFLGYGLVTATDHDIWYRQRRIMDPAFSSSYLRGLISTFNEMSERLMDKLEEMAINKTPAVMHDL 187

  Fly   174 AHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSK 238
            .:.:|||:||..|.||.:|..:...:...||.:.....:.:....|         |...:|   |
Zfish   188 VNCVTLDIICKVAFGVDLNLFKQTDNPFQQAIEQCLQGMVLDLRDP---------FCKFFP---K 240

  Fly   239 TLKTLQDFTNEIIAKR------IEVRKSGLEVG--IKADEFSRKKMAFLDTLLSSKVDGRPLTSQ 295
            ..|.:|:.....:..|      |:.||:.:|:|  :..|..::    .|.|....||:... ..:
Zfish   241 NWKAIQETKGATVLLRKTGEQWIQNRKTAVEIGEDVPNDILTQ----ILKTAKEEKVNNTK-DHE 300

  Fly   296 ELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKH 360
            ::.:...||...|.:||.:.:.||:..|.|||:..::...|..:|:|..   ||.:::::....:
Zfish   301 QMLDNFVTFFIAGQETTANQLSFAIMELGRHPEIYKRAKAEVDEVLGTK---RDISYEDLGKFTY 362

  Fly   361 LDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFD 425
            |...:||..||||:.|...|:..:|.||:|..:|.|.::.....:....::.||||.||.||||:
Zfish   363 LSQVLKETLRLYPTAPGTNRWLHEDMVINGIKIPGGISVIFSSYVAQRLEKHFKDPLKFDPERFN 427

  Fly   426 REKPGPFE-YVPFSAGPRNCIGQKF--------ALLEIKTVVSKIIRNFEVL 468
            ...|.|:. |.|||.|||:|:||.|        ||.::.|.:..:..:|.::
Zfish   428 VNAPKPYYCYYPFSLGPRSCLGQVFSQATPAEGALAQLLTQLLTLCSHFLIV 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	123/473 (26%)
cyp46a1.3	NP_001038763.1	p450	39..452	CDD:278495	118/444 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820