DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	467	Identity:	130/467 - (27%)
Similarity:	234/467 - (50%)	Gaps:	57/467 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 WIGYYSNIM-VTNPKYMEFILSSQTLISKSDV--YDLTHPWLGLGLLTSTGSKWHKHRKMITPAF 135
            |:|....:: :.:|.::..:|.:..|::..|.  :....||||.||..::|.||.:||:::||||
Mouse    91 WLGPVIPVLRIVDPAFVAPLLLASALVAPKDTTFHTFVKPWLGDGLFLNSGDKWSRHRRLLTPAF 155

  Fly   136 HFNILQDFHEVMNENSTKFIDQLKKVADGGNI-FDFQEEAHYLTLDVICDTAMGVSINAMENRSS 199
            ||:||:.:.::.|::......:.|.::..|:. .:..|....:|||.:.....|...|..|: .|
Mouse   156 HFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQES-PS 219

  Fly   200 SVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEV 264
            ..:.|..:::..:..|:...:....:|::...:...:.|....:.:||:.:|.:|.....|.
Mouse   220 EYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIRERRHTLSSQ--- 281

  Fly   265 GIKADEFSRKK-----MAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLL 323
              ..|||.:.|     :.|:|.||.:|.: |:.|:.:::..|..||||.|||||.|.:.:.:|.|
Mouse   282 --NHDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNL 344

  Fly   324 SRHPDEQEKLFNEQCDVMGASGLGR---DATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKD 385
            :|||:.||:...|..:::    .||   :..:.:::.:..|.:.|||:.||:|.|..:.|...:|
Mouse   345 ARHPEYQERCRQEVQELL----RGREPQEIEWDDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRD 405

  Fly   386 YVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDRE---KPGPFEYVPFSAGPRNCIG 446
            .|: ||.::|||....:.:..:.:|..|:.||..:.|.|||.|   |..|..::|||||||||||
Mouse   406 IVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENAHKRPPLAFIPFSAGPRNCIG 470

  Fly   447 QKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMT 511
            |.||:.|:...::..:..|.:||  |:                            .:|.....:.
Mouse   471 QTFAMNEMMVALALTLLRFRILP--DD----------------------------KEPRRKPEII 505

  Fly   512 LKSENGLHLRMK 523
            |::|.||.||::
Mouse   506 LRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	120/411 (29%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	128/463 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845192
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.640