DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4a31

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_964002.2	Gene:	Cyp4a31 / 666168	MGIID:	3028580	Length:	509	Species:	Mus musculus

Alignment Length:	549	Identity:	156/549 - (28%)
Similarity:	257/549 - (46%)	Gaps:	93/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGK 68
            |.|..|.|...:..|     |.||.:|...|               ..|:...:.|||  ||..|
Mouse    24 VFCLLLLLVKAVQVY-----LHRKWLLKALQ---------------QFPSPPFHWFFG--HEQFK 66

  Fly    69 ------------DNF-----RYWIGYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHPW 111
                        :||     |::.|..:.:.|.:|.||:.||      .:||     .|.|..||
Mouse    67 GDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVIL------GRSDPKANGAYRLLAPW 125

  Fly   112 LGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHY 176
            :|.|||...|..|.:||||:|||||::||:.:.:.|.::....:|:.:::|...:..:..:....
Mouse   126 IGYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISL 190

  Fly   177 LTLDVI--CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKT 239
            :|||.:  |..:...|:. ::....:.:||..|:...:..|..:.:.:|..::..:......::.
Mouse   191 MTLDTVMKCAFSHKGSVQ-VDGNYKTYLQAIGDLNNLVHSRVRNMFHQNDTIYKLSSNGRLSNQA 254

  Fly   240 LKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRK-KMAFLDTLLSSKVDGR-PLTSQELYEEVS 302
            .:...|.|:.:    |::||..|:...:.:...:| ::.|||.||.::::.. .::.::|..||.
Mouse   255 CQLAHDHTDGV----IKMRKDQLQDEGELENIKKKRRLDFLDILLFARMENEDSMSDKDLRAEVD 315

  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367
            |||.||||||.|||.:..|.|:.||:.|::...|   |....|.|...|:..:..:.:..:.|||
Mouse   316 TFMIEGHDTTASGVSWIFYALATHPEHQQRCREE---VQSLLGDGSSITWDHLDQIPYTTMCIKE 377

  Fly   368 AQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP-G 430
            |.||||.||.|||........ ||..:|||..:.|.:..|.:|.:|:.:|..|.|.||..:.| .
Mouse   378 ALRLYPPVPSIGRELSTSVTFPDGCSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRH 442

  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSR 495
            ...::|||.|.|||||::||:.|:|.:|:..:..||:||                  .|...
Mouse   443 SHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLP------------------DPTRV--- 486

  Fly   496 DAHNHKYDPILSASMTLKSENGLHLRMKQ 524
                    |:..|...|||:||::|.:|:
Mouse   487 --------PMSLARFVLKSKNGIYLHLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	135/462 (29%)
Cyp4a31	NP_964002.2	p450	52..503	CDD:278495	144/495 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650